Aspirin as an Antiplatelet Drug

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

COLLABORATIVE OVERVIEW OF RANDOMIZED TRIALS OF ANTIPLATELET THERAPY .1. PREVENTION OF DEATH, MYOCARDIAL-INFARCTION, AND STROKE BY PROLONGED ANTIPLATELET THERAPY IN VARIOUS CATEGORIES OF PATIENTS

1994 • 3,408 citations

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

1975 • 3,075 citations

Collaborative overview of randomised trials of antiplatelet therapy Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients

1994 • 2,993 citations

急性心筋梗塞の疑いのある17187症例におけるストレプトキナーゼ静脈内投与,アスピリン経口投与,上記2つの併用または無処置の無作偽試験 ISIS-2

1988 • 2,760 citations

The Pathogenesis of Coronary Artery Disease and the Acute Coronary Syndromes

1992 • 2,655 citations

Final Report on the Aspirin Component of the Ongoing Physicians' Health Study

1989 • 2,180 citations

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

Protective Effects of Aspirin against Acute Myocardial Infarction and Death in Men with Unstable Angina

1983 • 1,740 citations

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

1991 • 1,734 citations

Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke

1993 • 1,718 citations

Stroke Prevention in Atrial Fibrillation Study. Final results.

1991 • 1,695 citations

Aspirin, Heparin, or Both to Treat Acute Unstable Angina

1988 • 1,290 citations

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

1993 • 1,270 citations

Risk for Serious Gastrointestinal Complications Related to Use of Nonsteroidal Anti-inflammatory Drugs

1991 • 1,260 citations

Randomised trial of prophylactic daily aspirin in British male doctors

1988 • 1,178 citations

Platelet Activation in Unstable Coronary Disease

1986 • 1,161 citations

Aspirin, Sulfinpyrazone, or Both in Unstable Angina

1985 • 1,146 citations

The United Kingdom transient ischaemic attack (UK-TIA) aspirin trial: final results.

1991 • 1,145 citations

Acetylation of prostaglandin synthase by aspirin.

1975 • 1,003 citations

CLASP: a randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women

1994 • 965 citations

Secondary prevention of vascular disease by prolonged antiplatelet treatment

1988 • 962 citations

Selective Cumulative Inhibition of Platelet Thromboxane Production by Low-dose Aspirin in Healthy Subjects

1982 • 940 citations

Risk of myocardial infarction and death during treatment with low dose aspirin and intravenous heparin in men with unstable coronary artery disease

1990 • 751 citations

A Comparison of Two Doses of Aspirin (30 mg vs. 283 mg a Day) in Patients after a Transient Ischemic Attack or Minor Ischemic Stroke

1991 • 747 citations

Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man.

1983 • 675 citations

Low dose aspirin and inhibition of thromboxane B2 production in healthy subjects

1980 • 642 citations

Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence.

1988 • 604 citations

Thromboxane Biosynthesis and Platelet Function in Type II Diabetes Mellitus

1990 • 600 citations

Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment

1991 • 580 citations

Collaborative overview of randomised trials of antiplatelet therapy--III: Reduction in venous thrombosis and pulmonary embolism by antiplatelet prophylaxis among surgical and medical patients. Antiplatelet Trialists' Collaboration.

1994 • 570 citations

A Comparison of Aspirin with Placebo in Patients Treated with Warfarin after Heart-Valve Replacement

1993 • 563 citations

Dose-Related Kinetics of Aspirin

1984 • 552 citations

Inhibition of platelet prostaglandin synthetase by oral aspirin.

1978 • 552 citations

Heparin: Mechanism of Action, Pharmacokinetics, Dosing Considerations, Monitoring, Efficacy, and Safety

1992 • 548 citations

Swedish Aspirin Low-dose Trial (SALT) of 75 mg aspirin as secondary prophylaxis after cerebrovascular ischaemic events

1991 • 525 citations

Double-blind trial of aspirin in primary prevention of myocardial infarction in patients with stable chronic angina pectoris

1992 • 509 citations

Collaborative overview of randomised trials of antiplatelet therapy - III: Reduction in venous thrombosis and pulmonary embolism by antiplatelet prophylaxis among surgical and medical patients

1994 • 507 citations

Collaborative overview of randomised trials of antiplatelet therapy - II: Maintenance of vascular graft or arterial patency by antiplatelet therapy

1994 • 483 citations

Reactivation of Unstable Angina after the Discontinuation of Heparin

1992 • 473 citations

Persantine and aspirin in coronary heart disease. The Persantine-Aspirin Reinfarction Study Research Group.

1980 • 464 citations

Differential Inhibition by Aspirin of Vascular and Platelet Prostaglandin Synthesis in Atherosclerotic Patients

1983 • 460 citations

Clinical Implications of Prostaglandin and Thromboxane A₂Formation

1988 • 450 citations

Clinical pharmacology of platelet cyclooxygenase inhibition.

1985 • 432 citations

Mechanisms of platelet activation: Thromboxane A2 as an amplifying signal for other agonists

1991 • 349 citations

Suppression of Thromboxane A₂but Not of Systemic Prostacyclin by Controlled-Release Aspirin

1991 • 333 citations

IMPROVED AORTOCORONARY BYPASS PATENCY BY LOW-DOSE ASPIRIN (100 mg DAILY)

1984 • 319 citations

The clinical significance of inhibition of renal prostaglandin synthesis

1987 • 299 citations

The gastrointestinal toxicity of aspirin: an overview of randomised controlled trials.

1993 • 292 citations

Hypertension in Pregnancy

1992 • 261 citations

Aspirin and other antiplatelet agents in the secondary and primary prevention of cardiovascular disease.

1989 • 251 citations

Prevention of Thrombosis in Patients on Hemodialysis by Low-Dose Aspirin

1979 • 248 citations

Counteraction of the vasodilator effects of enalapril by aspirin in severe heart failure

1992 • 240 citations

Estimated rate of thromboxane secretion into the circulation of normal humans.

1986 • 234 citations

Low-Dose Aspirin Therapy for Chronic Stable Angina

1991 • 227 citations

Antithrombotic Therapy in Peripheral Arterial Occlusive Disease

1992 • 222 citations

Nonsteroidal Anti-inflammatory Drugs and the Risk for Chronic Renal Disease

1991 • 210 citations

Angioplasty triggers intracoronary leukotrienes and lipoxin A4. Impact of aspirin therapy.

1992 • 194 citations

Biochemical evidence of platelet activation in patients with persistent unstable angina

1987 • 178 citations

The Use of Aspirin in Ischemic Heart Disease

1992 • 177 citations

High-dose aspirin inhibits shear-induced platelet reaction involving thrombin generation.

1992 • 154 citations

Aspirin acetylates fibrinogen and enhances fibrinolysis. Fibrinolytic effect is independent of changes in plasminogen activator levels.

1989 • 137 citations

Aspirin and human platelets: from clinical trials to acetylation of cyclooxygenase and back

1989 • 127 citations

Dissociation of Platelet Activation and Spontaneous Myocardial Ischemia in Unstable Angina

1990 • 119 citations

Antiplatelet drugs and generation of thrombin in clotting blood

1992 • 108 citations

Increased thromboxane biosynthesis in patients with polycythemia vera: evidence for aspirin-suppressible platelet activation in vivo [see comments]

1992 • 108 citations

Increased thromboxane biosynthesis in patients with polycythemia vera: evidence for aspirin-suppressible platelet activation in vivo [see comments]

1992 • 104 citations

Antithrombotic therapy in cardiac disease. An emerging approach based on pathogenesis and risk.

1989 • 103 citations

Aspirin effects on mortality and morbidity in patients with diabetes mellitus. Early Treatment Diabetic Retinopathy Study report 14. ETDRS Investigators

1992 • 99 citations

Prevention of early aortocoronary bypass occlusion by low-dose aspirin and dipyridamole. Grupo Español para el Seguimiento del Injerto Coronario (GESIC)

1990 • 98 citations

Antiplatelet drugs and generation of thrombin in clotting blood

1992 • 97 citations

Extra-Cranial Bleeding and Other Symptoms due to Low Dose Aspirin and Low Intensity Oral Anticoagulation

1992 • 94 citations

Increased thromboxane biosynthesis in patients with acute cerebral ischemia.

1993 • 91 citations

A randomized, controlled trial of aspirin in persons recovered from myocardial infarction

1980 • 89 citations

Evidence for episodic platelet activation in acute ischemic stroke.

1994 • 84 citations

Aspirin as an Antithrombotic Medication

1983 • 79 citations

A prospective study of mortality among middle-aged diabetic patients (the London cohort of the WHO Multinational Study of Vascular Disease in Diabetics) I: causes and death rates

1990 • 78 citations

Secondary prevention of stroke

1992 • 72 citations

Prevention of serious cardiac events by low-dose aspirin in patients with silent myocardial ischaemia

1992 • 70 citations

Equal Antiplatelet Effects of Aspirin 50 or 324 mg/Day in Patients After Acute Myocardial Infarction

1985 • 61 citations

A prospective study of aspirin use and primary prevention of cardiovascular disease in women

1991 • 49 citations

Low-dose aspirin in patients recovering from myocardial infarction. Evidence for a selective inhibition of thromboxane-related platelet function

1985 • 44 citations

Low-dose warfarin and low-dose aspirin in the primary prevention of ischemic heart disease

1990 • 42 citations

Transdermal modification of platelet function. A dermal aspirin preparation selectively inhibits platelet cyclooxygenase and preserves prostacyclin biosynthesis.

1993 • 33 citations

Effects of non‐steroidal anti‐inflammatory drugs on prostacyclin and thromboxane biosynthesis in patients with mild essential hypertension.

1990 • 17 citations