Pyk2 is differentially regulated by β1 integrin- and CD28-mediated co-stimulation in human CD4+ T lymphocytes

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Current protocols in immunology

1992 • 1,464 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

1996 • 971 citations

T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-lβ

1993 • 896 citations

Regulated expression and binding of three VLA (β1) integrin receptors on T cells

1990 • 634 citations

ICAM-1 a ligand for LFA-1-dependent adhesion of B, T and myeloid cells

1988 • 580 citations

Signaling through focal adhesion kinase

1997 • 468 citations

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4 ⁺ T Cells

1996 • 438 citations

Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways

1997 • 401 citations

Costimulation of proliferative responses of resting CD4+ T cells by the interaction of VLA-4 and VLA-5 with fibronectin or VLA-6 with laminin.

1990 • 400 citations

Integrin cytoplasmic interactions and bidirectional transmembrane signalling

1996 • 396 citations

Cloning and Characterization of Cell Adhesion Kinase β, a Novel Protein-tyrosine Kinase of the Focal Adhesion Kinase Subfamily

1995 • 385 citations

Identification and Characterization of a Novel Related Adhesion Focal Tyrosine Kinase (RAFTK) from Megakaryocytes and Brain

1995 • 365 citations

Lymphocyte interactions with extracellular matrix

1991 • 336 citations

Activation of Pyk2 by Stress Signals and Coupling with JNK Signaling Pathway

1996 • 310 citations

Integrin-mediated signalling: regulation by protein tyrosine kinases and small GTP-binding proteins

1996 • 305 citations

Analysis of T cell stimulation by superantigen plus major histocompatibility complex class II molecules or by CD3 monoclonal antibody: costimulation by purified adhesion ligands VCAM-1, ICAM-1, but not ELAM-1.

1991 • 293 citations

Regulation of leukocyte integrin function: Affinity vs. avidity

1996 • 244 citations

Fibronectin promotes proliferation of naive and memory T cells by signaling through both the VLA-4 and VLA-5 integrin molecules.

1990 • 241 citations

Vascular cell adhesion molecule 1 induces T-cell antigen receptor-dependent activation of CD4+T lymphocytes.

1991 • 234 citations

VLA-4 mediates CD3-dependent CD4+ T cell activation via the CS1 alternatively spliced domain of fibronectin.

1990 • 224 citations

The Related Adhesion Focal Tyrosine Kinase Is Tyrosine-phosphorylated after β1-Integrin Stimulation in B Cells and Binds to p130cas

1997 • 214 citations

The accessory function of murine intercellular adhesion molecule-1 in T lymphocyte activation. Contributions of adhesion and co-activation.

1991 • 197 citations

Beta 2-integrin LFA-1 signaling through phospholipase C-gamma 1 activation.

1993 • 185 citations

Multiple p21ras effector pathways regulate nuclear factor of activated T cells.

1996 • 168 citations

Roles of multiple accessory molecules in T-cell activation

1991 • 167 citations

p21ras mediates control of IL-2 gene promoter function in T cell activation.

1992 • 166 citations

Tyrosine Phosphorylation of Pyk2 Is Selectively Regulated by Fyn During TCR Signaling

1997 • 165 citations

Activation of human CD4 T lymphocytes. Interaction of fibronectin with VLA-5 receptor on CD4 cells induces the AP-1 transcription factor.

1991 • 154 citations

Stimulation of integrin-mediated adhesion of T lymphocytes and monocytes: two mechanisms with divergent biological consequences.

1994 • 149 citations

Signaling by vascular cell adhesion molecule‐1 (VCAM‐1) through VLA‐4 promotes CD3‐dependent T cell proliferation

1991 • 131 citations

Role of the VLA-4 molecule in T cell costimulation. Identification of the tyrosine phosphorylation pattern induced by the ligation of VLA-4.

1995 • 118 citations

A high affinity conformational state on VLA integrin heterodimers induced by an anti-beta 1 chain monoclonal antibody

1993 • 108 citations

RAFTK, a Novel Member of the Focal Adhesion Kinase Family, Is Phosphorylated and Associates with Signaling Molecules upon Activation of Mature T Lymphocytes

1997 • 107 citations

Costimulation of T cell receptor/CD3-mediated activation of resting human CD4+ T cells by leukocyte function-associated antigen-1 ligand intercellular cell adhesion molecule-1 involves prolonged inositol phospholipid hydrolysis and sustained increase of intracellular Ca2+ levels.

1992 • 106 citations

T cell receptor- and beta 1 integrin-mediated signals synergize to induce tyrosine phosphorylation of focal adhesion kinase (pp125FAK) in human T cells.

1995 • 92 citations

The alpha 4 integrin chain is a ligand for alpha 4 beta 7 and alpha 4 beta 1.

1995 • 87 citations

T cell receptor engagement induces tyrosine phosphorylation of FAK and Pyk2 and their association with Lck.

1997 • 79 citations

Proline-rich tyrosine kinase-2 activation by beta 1 integrin fibronectin receptor cross-linking and association with paxillin in human natural killer cells.

1997 • 72 citations

Interleukin-2 promoter activation in T-cells expressing activated Ha-ras.

1992 • 60 citations

Cytotoxic T lymphocytes express a β₃ integrin which can induce the phosphorylation of focal adhesion kinase and the related PYK‐2

1997 • 51 citations

Costimulation via Vascular Cell Adhesion Molecule-1 Induces in T Cells Increased Responsiveness to the CD28 Counter-receptor B7

1993 • 33 citations