Plasmid DNA Is Superior to Viral Vectors for Direct Gene Transfer into Adult Mouse Skeletal Muscle

Direct Gene Transfer into Mouse Muscle in Vivo

1990 • 3,985 citations

Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein

1993 • 2,330 citations

Human gene therapy comes of age

1992 • 927 citations

Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer.

1987 • 881 citations

Long-term persistence of plasmid DNA and foreign gone expression in mouse muscle

1992 • 743 citations

Widespread long-term gene transfer to mouse skeletal muscles and heart.

1992 • 586 citations

Construction of plasmids that expressE.coli β-galactosidase in mammalian cells

1989 • 458 citations

Efficient adenovirus-mediated transfer of a human minidystrophin gene to skeletal muscle of mdx mice

1993 • 455 citations

Gene Therapy by Intramuscular Injection of Plasmid DNA: Studies on Firefly Luciferase Gene Expression in Mice

1993 • 440 citations

DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody

1993 • 401 citations

Direct Gene Transfer into Skeletal MuscleIn Vivo: Factors Affecting Efficiency of Transfer and Stability of Expression

1993 • 380 citations

Gene therapy via primary myoblasts: long-term expression of factor IX protein following transplantation in vivo.

1992 • 313 citations

Adenovirus as an expression vector in muscle cells in vivo.

1992 • 301 citations

Accelerated age-related decline in replicative life-span of Duchenne muscular dystrophy myoblasts: Implications for cell and gene therapy

1990 • 292 citations

Systemic Delivery of Recombinant Proteins by Genetically Modified Myoblasts

1991 • 284 citations

NATURE OF DIVIDING NUCLEI IN SKELETAL MUSCLE OF GROWING RATS

1970 • 281 citations

Destruction and regeneration of skeletal muscle after treatment with a local anaesthetic, bupivacaine (Marcaine).

1970 • 276 citations

Powerful and versatile enhancer-promoter unit for mammalian expression vectors

1986 • 263 citations

Conditions affecting direct gene transfer into rodent muscle in vivo.

1991 • 262 citations

Expression of myosin isoforms during notexin-induced regeneration of rat soleus muscles

1990 • 237 citations

Direct gene transfer and expression into rat heart in vivo.

1991 • 208 citations

Expression of naked plasmids by cultured myotubes and entry of plasmids into T tubules and caveolae of mammalian skeletal muscle

1992 • 206 citations

Pathological responses of rat skeletal muscle to a single subcutaneous injection of a toxin isolated from the venom of the Australian tiger snake, Notechis scutatus scutatus

1975 • 203 citations

Muscle fiber pattern is independent of cell lineage in postnatal rodent development

1992 • 202 citations

Expression of human factor IX in mice after injection of genetically modified myoblasts.

1992 • 142 citations

Ultrastructural study of experimental muscle degeneration and regeneration in the adult rat

1972 • 136 citations

Folding of Circularly Permuted Transfer RNAs

1991 • 115 citations

A microtransfection method using the luciferase-encoding reporter gene for the assay of human immunodeficiency virus LTR promoter activity

1990 • 104 citations

Regeneration of mammalian skeletal muscle following the injection of the snake-venom toxin, taipoxin

1983 • 80 citations

Changes in motor end-plates resulting from muscle fibre necrosis and regeneration

1974 • 75 citations

Development of apposed sarcoplasmic reticulum at the T system and sarcolemma and the change in orientation of triads in rat skeletal muscle

1970 • 63 citations

Age and sex influence expression of plasmid DNA directly injected into mouse skeletal muscle

1992 • 61 citations

Myosin isoform transitions in regeneration of fast and slow muscles during postnatal development of the rat

1989 • 58 citations

Stable incorporation of a bacterial gene into adult rat skeletal muscle in vivo

1990 • 44 citations

Influence of the dwarf mouse mutation on skeletal and cardiac myosin isoforms. Effect of one injection of thyroxine on skeletal and cardiac muscle phenotype.

1987 • 35 citations

Twin Quasars Found

1990 • 23 citations

The effect of partial denervation of tibialis anterior (TA) muscle on the number and sizes of motorneurons in TA motornucleus of normal and dystrophic (C57BL dy^2j/dy^2j) mice

1991 • 17 citations