Congenital Myasthenic Syndrome Caused by Decreased Agonist Binding Affinity Due to a Mutation in the Acetylcholine Receptor ε Subunit

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

1987 • 5,139 citations

Molecular distinction between fetal and adult forms of muscle acetylcholine receptor

1986 • 979 citations

Data transformations for improved display and fitting of single-channel dwell time histograms

1987 • 828 citations

Fast events in single‐channel currents activated by acetylcholine and its analogues at the frog muscle end‐plate.

1985 • 768 citations

The binding of acetylcholine to receptors and its removal from the synaptic cleft

1973 • 576 citations

A quantitative study of end‐plate potentials in isolated human muscle.

1965 • 565 citations

On the factors which determine the amplitude of the ‘miniature end‐plate potential’

1957 • 458 citations

Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events

1996 • 432 citations

‘Cold SSCP’: a simple, rapid and non-radioactive method for optimized single-strand conformation polymorphism analyses

1993 • 335 citations

Quantal Nature of Synaptic Transmission

1966 • 329 citations

Molecular basis of the two nonequivalent ligand binding sites of the muscle nicotinic acetylcholine receptor

1989 • 279 citations

Mutation of the acetylcholine receptor α subunit causes a slow-channel myasthenic syndrome by enhancing agonist binding affinity

1995 • 263 citations

Congenital myasthenic syndrome caused by prolonged acetylcholine receptor channel openings due to a mutation in the M2 domain of the epsilon subunit.

1995 • 252 citations

Ultrastructural localization of the acetylcholine receptor in myasthenia gravis and in its experimental autoimmune model

1977 • 244 citations

Activation of Torpedo acetylcholine receptors expressed in mouse fibroblasts. Single channel current kinetics reveal distinct agonist binding affinities.

1990 • 193 citations

Functional consequences of agonist-mediated state transitions in the cholinergic receptor. Studies in cultured muscle cells.

1979 • 191 citations

Antibodies to motor nerve terminals: an electrophysiological study of a human myasthenic syndrome transferred to mouse.

1983 • 191 citations

Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of residues that determine curare selectivity.

1993 • 186 citations

A muscle acetylcholine receptor is expressed in the human cerebellar medulloblastoma cell line TE671

1989 • 186 citations

Functional differences among nonerythroid anion exchangers expressed in a transfected human cell line

1991 • 180 citations

Molecular dissection of subunit interfaces in the acetylcholine receptor: Identification of determinants of α-Conotoxin M1 selectivity

1995 • 164 citations

Gamma- and delta-subunits regulate the affinity and the cooperativity of ligand binding to the acetylcholine receptor.

1991 • 163 citations

Structural basis of the different gating kinetics of fetal and adult acetylcholine receptors

1994 • 146 citations

Kinetics of agonist-mediated transitions in state of the cholinergic receptor.

1977 • 143 citations

Perfection of a synaptic receptor: kinetics and energetics of the acetylcholine receptor.

1989 • 137 citations

Local anesthetics and histrionicotoxin are allosteric inhibitors of the acetylcholine receptor. Studies of clonal muscle cells.

1982 • 114 citations

The human medulloblastoma cell line TE671 expresses a muscle‐like acetylcholine receptor Cloning of the α‐subunit cDNA

1988 • 110 citations

Molecular Dissection of Subunit Interfaces in the Acetylcholine Receptor

1996 • 92 citations

Effects of 4-aminopyridine and 3,4-diaminopyridine on transmitter release at the neuromuscular junction.

1983 • 83 citations

Activation of recombinant mouse acetylcholine receptors by acetylcholine, carbamylcholine and tetramethylammonium.

1995 • 82 citations

Primary structure of the human muscle acetylcholine receptor

1993 • 73 citations

Congenital myasthenic syndromes: I. Deficiency and short open‐time of the acetylcholine receptor

1993 • 70 citations

Congenital myasthenic syndromes: II. Syndrome attributed to abnormal interaction of acetylcholine with its receptor

1993 • 70 citations

Site-directed mutagenesis of the conserved N-glycosylation site on the nicotinic acetylcholine receptor subunits

1991 • 67 citations

Competitive antagonists bridge the alpha-gamma subunit interface of the acetylcholine receptor through quaternary ammonium-aromatic interactions

1994 • 63 citations

Functional consequences of agonist-mediated state transitions in the cholinergic receptor

1979 • 60 citations

Activation kinetics of recombinant mouse nicotinic acetylcholine receptors: mutations of alpha-subunit tyrosine 190 affect both binding and gating

1995 • 53 citations

Patch‐clamp analysis of the properties of acetylcholine receptor channels at the normal human endplate

1994 • 42 citations

Nucleotide sequence of human muscle acetylcholine receptor β-subunit

1989 • 37 citations

Congenital Myasthenic Syndromes

2011 • 35 citations

Megaprimer method for in vitro mutagenesis using parallel templates.

1995 • 15 citations

Characterization of an adult muscle acetylcholine receptor subunit by expression in fibroblasts

1991 • 13 citations

The kyoto surprise box

1995 • 11 citations