TNF-receptor 1 deficiency fails to alter the clinical and pathological course in mice with globoid cell leukodystrophy (twitcher mice) but affords protection following LPS challenge

Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

1993 • 1,267 citations

The Tumor Necrosis Factor Ligand and Receptor Families

1996 • 1,239 citations

Correlations and interactions in the production of interleukin-6 (IL- 6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF

1990 • 991 citations

Tumor Necrosis Factor, Other Cytokines and Disease

1993 • 788 citations

Cytokines in inflammatory brain lesions: helpful and harmful

1996 • 727 citations

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

1990 • 692 citations

Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice

1994 • 607 citations

IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice.

1989 • 578 citations

TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination

1998 • 553 citations

Cytokine cytotoxicity against oligodendrocytes. Apoptosis induced by lymphotoxin.

1991 • 455 citations

Anti—tumor necrosis factor therapy abrogates autoimmune demyelination

1991 • 434 citations

Unraveling Function in the TNF Ligand and Receptor Families

1994 • 431 citations

TNF-alpha expression by resident microglia and infiltrating leukocytes in the central nervous system of mice with experimental allergic encephalomyelitis. Regulation by Th1 cytokines.

1995 • 401 citations

Activation of the 55 kDa TNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis, and nitrite release.

1995 • 332 citations

Oligodendrocyte Apoptosis and Primary Demyelination Induced by Local TNF/p55TNF Receptor Signaling in the Central Nervous System of Transgenic Mice

1998 • 317 citations

The twitcher mouse: an enzymatically authentic model of human globoid cell leukodystrophy (Krabbe disease)

1980 • 251 citations

Neurological Mutations Affecting Myelination

1981 • 242 citations

HEREDITARY LEUCODYSTROPHY IN THE MOUSE: THE NEW MUTANT TWITCHER

1980 • 236 citations

Control of established experimental allergic encephalomyelitis by inhibition of tumor necrosis factor (TNF) activity within the central nervous system using monoclonal antibodies and TNF receptor‐immunoglobulin fusion proteins

1994 • 232 citations

Severity of symptoms and demyelination in MOG-induced EAE depends on TNFR1

1999 • 201 citations

Tumor Necrosis Factor α and Lymphotoxin α Are Not Required for Induction of Acute Experimental Autoimmune Encephalomyelitis

1997 • 197 citations

Molecular Cloning and Expression of cDNA for Murine Galactocerebrosidase and Mutation Analysis of the Twitcher Mouse, a Model of Krabbe's Disease

1996 • 187 citations

Prevention of chronic relapsing experimental autoimmune encephalomyelitis by soluble tumor necrosis factor receptor I

1995 • 177 citations

Transcriptional activation of IL-1 beta and tumor necrosis factor-alpha genes by MHC class II ligands.

1991 • 155 citations

Cloning and expression cDNA encoding human galactocerebrosidase, the enzyme deficient in globoid cell leukodystrophy

1993 • 148 citations

Regulation of the Gene Encoding Tumor Necrosis Factor Alpha (TNF-α) in the Rat Brain and Pituitary in Response to Different Models of Systemic Immune Challenge

1999 • 140 citations

TNF-α receptor fusion protein prevents experimental auto-immune encephalomyelitis and demyelination in Lewis rats: an overview

1997 • 132 citations

Absence of MHC class ii molecules reduces CNS demyelination, microglial/macrophage infiltration, and twitching in murine globoid cell leukodystrophy

1994 • 112 citations

Blood-brain barrier permeability to horseradish peroxidase in twitcher and cuprizone-intoxicated mice

1987 • 107 citations

TNF accelerates the onset but does not alter the incidence and severity of myelin basic protein-induced experimental autoimmune encephalomyelitis

1999 • 93 citations

IL-6 and TNFα expression in brains of twitcher, quaking and normal mice

1997 • 87 citations

Intracarotid tumor necrosis factor-α administration increases the blood-brain barrier permeability in cerebral cortex of the newborn pig: quantitative aspects of double-labelling studies and confocal laser scanning analysis

1996 • 81 citations

Impairment of TNF-Receptor-1 Signaling but not Fas Signaling Diminishes T-Cell Apoptosis in Myelin Oligodendrocyte Glycoprotein Peptide-Induced Chronic Demyelinating Autoimmune Encephalomyelitis in Mice

1999 • 79 citations

Unimpaired autoreactive T-cell traffic within the central nervous system during tumor necrosis factor receptor-mediated inhibition of experimental autoimmune encephalomyelitis.

1995 • 66 citations

L-cycloserine slows the clinical and pathological course in mice with globoid cell leukodystrophy (twitcher mice)

2000 • 65 citations

Inhibition of tumor necrosis factor is protective against neurologic dysfunction after active immunization of lewis rats with myelin basic protein

1995 • 62 citations

The twitcher mouse. A model of human globoid cell leukodystrophy (krabbe's disease).

1983 • 59 citations

Myelinolytic lesions in spinal cord of cobalamin‐deficient rats are TNF‐α‐mediated

1999 • 52 citations

IL-6 Deficiency Causes Enhanced Pathology in Twitcher (Globoid Cell Leukodystrophy) Mice

1999 • 43 citations

MHC class II antigen expression and T-cell infiltration in the demyelinating CNS and PNS of the twitcher mouse

1993 • 40 citations

Demyelination in the spinal cord of murine globoid cell leukodystrophy (the twitcher mouse)

1984 • 37 citations

Neuropathology of twitcher mice: examination by histochemistry, immunohistochemistry, lectin histochemistry and fourier transform infrared microspectroscopy

1994 • 37 citations

The twitcher mouse: An ultrastructural study on the oligodendroglia

1983 • 37 citations

Suppression of experimental autoimmune encephalomyelitis with a TNF binding protein (TNFbp) correlates with down-regulation of VCAM-1/VLA-4

1998 • 37 citations

Morphological features of degenerating oligodendrocytes in twitcher mice

1992 • 27 citations

Tumor necrosis factor alpha but not lymphotoxin is overproduced by blood mononuclear cells in multiple sclerosis.

1995 • 25 citations

Propentofylline and Iloprost Suppress the Production of TNF-αby Macrophages but Fail to Ameliorate Experimental Autoimmune Encephalomyelitis in Lewis Rats

1997 • 25 citations

Myelin Pathology in the Twitcher Mouse^a

1990 • 18 citations

Transport of a hydrophilic compound into the cerebrospinal fluid during experimental allergic encephalomyelitis and after lipopolysaccharide administration.

1995 • 17 citations

The Twitcher Mouse: Immunocytochemical Study of Ia Expression in Macrophages

1992 • 17 citations

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