Propentofylline and Iloprost Suppress the Production of TNF-αby Macrophages but Fail to Ameliorate Experimental Autoimmune Encephalomyelitis in Lewis Rats

Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors

1990 • 860 citations

Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines.

1991 • 835 citations

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

1990 • 692 citations

Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production.

1995 • 676 citations

A new view of prostaglandin E regulation of the immune response

1991 • 535 citations

The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response

1988 • 533 citations

Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages.

1990 • 511 citations

Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway.

1990 • 509 citations

Prostaglandin E2 differentially modulates cytokine secretion profiles of human T helper lymphocytes.

1993 • 491 citations

Phosphodiesterase inhibitors: new opportunities for the treatment of asthma.

1991 • 383 citations

The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis

1995 • 345 citations

A Textbook of Neuropathology

1950 • 325 citations

The antiplatelet and cardiovascular actions of a new carbacyclin derivative (ZK 36 374) ? Equipotent to PGI2 in vitro

1981 • 220 citations

Animal models of human disease Experimental autoimmune encephalomyelitis in rodents as a model for human demyelinating disease

1995 • 218 citations

cAMP inhibits induction of interleukin 2 but not of interleukin 4 in T cells.

1990 • 218 citations

Inflammatory mediators in demyelinating disorders of the CNS and PNS

1992 • 213 citations

Elevated cyclic AMP inhibits endothelial cell synthesis and expression of TNF-induced endothelial leukocyte adhesion molecule-1, and vascular cell adhesion molecule-1, but not intercellular adhesion molecule-1.

1993 • 192 citations

Role of phosphodiesterases in the regulation of endothelial permeability in vitro.

1993 • 189 citations

Prevention of chronic relapsing experimental autoimmune encephalomyelitis by soluble tumor necrosis factor receptor I

1995 • 177 citations

Phosphodiesterase inhibitor pentoxifylline, a selective suppressor of T helper type 1‐ but not type 2‐associated lymphokine production, prevents induction of experimental autoimmune encephalomyelitis in Lewis rats

1993 • 168 citations

Protective effect of adenosine and a novel xanthine derivative propentofylline on the cell damage after bilateral carotid occlusion in the gerbil hippocampus

1990 • 164 citations

Inhibition of chemotactic peptide-induced neutrophil adhesion to vascular endothelium by cAMP modulators.

1995 • 152 citations

Phosphorylation results in activation of a cAMP phosphodiesterase in human platelets.

1988 • 146 citations

The role of cAMP regulation in controlling inflammation

1995 • 131 citations

Multiple high-affinity cAMP-phosphodiesterases in human T-lymphocytes

1991 • 130 citations

[31] Myelin basic proteins

1974 • 111 citations

Prostacyclin analogs suppress the synthesis of tumor necrosis factor-α in LPS-stimulated human peripheral blood mononuclear cells

1993 • 102 citations

Phosphodiesterase inhibitory profile of some related xanthine derivatives pharmacologically active on the peripheral microcirculation

1994 • 101 citations

Inhibition of the transendothelial migration of human T lymphocytes by prostaglandin E2.

1994 • 86 citations

Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response

1993 • 86 citations

Enhanced tumor necrosis factor suppression and cyclic adenosine monophosphate accumulation by combination of phosphodiesterase inhibitors and prostanoids

1995 • 80 citations

Suppression of mesangial proliferative glomerulonephritis development in rats by inhibitors of cAMP phosphodiesterase isozymes types III and IV.

1996 • 75 citations

Protection against ischemic brain damage using propentofylline in gerbils.

1988 • 69 citations

Role of cAMP in regulating cytotoxic T lymphocyte adhesion and motility

1993 • 66 citations

Prostaglandins and inhibitors of arachidonate metabolism suppress experimental allergic encephalomyelitis

1994 • 65 citations

Pentoxifylline: a potent inhibitor of IL-2 and IFN-gamma biosynthesis and BCG-induced cytotoxicity.

1993 • 64 citations

Preventive but not therapeutic application of Rolipram ameliorates experimental autoimmune encephalomyelitis in Lewis rats

1996 • 64 citations

Pentoxifylline inhibits experimental allergic encephalomyelitis

2009 • 59 citations

A New Cyclic Nucleotide Phosphodiesterase Isozyme Expressed in the T-Lymphocyte Cell Lines

1993 • 52 citations

Textbook of Neuropathology

1992 • 47 citations

Pathogenesis of inflammatory demyelination

1995 • 41 citations

Prostaglandin E1 inhibits effector T cell induction and tissue damage in experimental murine interstitial nephritis.

1987 • 33 citations

Suppression of experimental autoimmune encephalomyelitis in Lewis rats by antibodies against CD2

1995 • 33 citations

Effects of prostacyclin analogs on the synthesis of tissue factor, tumor necrosis factor-alpha and interleukin-1 beta in human monocytic THP-1 cells.

1994 • 32 citations

Effect of leukotriene B4 and prostaglandin E2 on the adhesion of lymphocytes to endothelial cells

1990 • 31 citations

Suppression of human lymphocyte migration by PGE2

1981 • 31 citations

Inhibition of Endotoxin-Induced Macrophage Tumor Necrosis Factor Expression by a Prostacyclin Analogue and Its Beneficial Effect in Experimental Lipopolysaccharide Intoxication

1992 • 30 citations

Protective effect of prostaglandin E1 on ischemia-induced acute renal failure in dogs.

1985 • 29 citations

Inhibition of the transendothelial migration of human lymphocytes but not monocytes by phosphodiesterase inhibitors

1996 • 27 citations

THE SYNERGISTIC EFFECT OF CYCLOSPORINE AND ILOPROST ON SURVIVAL OF RAT CARDIAC ALLOGRAFTS

1986 • 18 citations

Prevention of murine cerebral malaria by a stable prostacyclin analog

1991 • 14 citations

Attenuation of immune complex nephritis in NZB/WF1 mice by a prostacyclin analogue

1995 • 12 citations

Impact of 15-deoxyspergualin on effector cells in experimental autoimmune diseases of the nervous system in the Lewis rat

1994 • 11 citations

Prolongation of guinea pig-to-rat xenograft survival with BN 52063, a specific antagonist of platelet-activating factor.

1989 • 6 citations

THE SYNERGISTIC EFFECT OF CYCLOSPORINE AND ILOPROST ON SURVIVAL OF ART CARDIAC ALLOGRAFTS

1986 • 6 citations