Covalent Dimerization of CD28/CTLA-4 and Oligomerization of CD80/CD86 Regulate T Cell Costimulatory Interactions

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

1995 • 2,090 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

1992 • 1,290 citations

Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors

1991 • 1,263 citations

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

1995 • 1,143 citations

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 • 1,132 citations

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

1994 • 950 citations

Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.

1992 • 592 citations

B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4

1995 • 577 citations

CTLA4 mediates antigen-specific apoptosis of human T cells.

1995 • 331 citations

CD28-B7 interactions in T-cell activation

1994 • 315 citations

Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity

1994 • 294 citations

T Cell Receptor-MHC Class I Peptide Interactions: Affinity, Kinetics, and Specificity

1994 • 292 citations

Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1.

1994 • 236 citations

Kinetics of ligand binding to receptor immobilized in a polymer matrix, as detected with an evanescent wave biosensor. I. A computer simulation of the influence of mass transport

1996 • 232 citations

Human Cell-Adhesion Molecule CD2 Binds CD58 (LFA-3) with a Very Low Affinity and an Extremely Fast Dissociation Rate but Does Not Bind CD48 or CD59

1994 • 204 citations

Expression and function of B7 on human epidermal Langerhans cells.

1993 • 166 citations

Genes for SMA: Multum in parvo

1995 • 121 citations

Binding Stoichiometry of the Cytotoxic T Lymphocyte-associated Molecule-4 (CTLA-4)

1995 • 106 citations

Distinct roles for CD28 and cytotoxic T lymphocyte-associated molecule-4 receptors during T cell activation?

1995 • 104 citations

Direct detection of major histocompatibility complex class I binding to antigenic peptides using surface plasmon resonance. Peptide immobilization and characterization of binding specificity

1993 • 78 citations

Differential effects of CTLA-4 substitutions on the binding of human CD80 (B7-1) and CD86 (B7-2).

1996 • 77 citations

Cleavable CD40Ig fusion proteins and the binding to sgp39

1995 • 20 citations

CD28/CTLA-4 receptor structure, binding stoichiometry and aggregation during T-cell activation

1995 • 14 citations