Cleavable CD40Ig fusion proteins and the binding to sgp39

Molecular and biological characterization of a murine ligand for CD40

1992 • 1,029 citations

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

1993 • 840 citations

CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM Syndrome

1993 • 836 citations

A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells.

1992 • 818 citations

Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM

1993 • 739 citations

CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM

1993 • 719 citations

CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40.

1993 • 593 citations

Current protocols in immunology

1993 • 551 citations

A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas.

1989 • 527 citations

The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity.

1992 • 518 citations

Prevention of Collagen-Induced Arthritis with an Antibody to gp39, the Ligand for CD40

1993 • 471 citations

Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50.

1986 • 439 citations

Expression of functional CD40 by vascular endothelial cells.

1995 • 414 citations

Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM.

1993 • 372 citations

In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39.

1993 • 354 citations

Anti-CD40 monoclonal antibodies or CD4+ T cell clones and IL-4 induce IgG4 and IgE switching in purified human B cells via different signaling pathways.

1991 • 270 citations

CD40 is functionally expressed on human thymic epithelial cells.

1992 • 261 citations

New vectors for high level expression of recombinant proteins in bacteria

1992 • 244 citations

Antibody to the ligand of CD40, gp39, blocks the occurrence of the acute and chronic forms of graft-vs-host disease.

1994 • 187 citations

Memory B cell development but not germinal center formation is impaired by in vivo blockade of CD40-CD40 ligand interaction.

1994 • 182 citations

A p50 surface antigen restricted to human urinary bladder carcinomas and B lymphocytes

1985 • 169 citations

Identification of a human epithelial cell surface protein sharing an epitope with the C3d/epstein‐barr virus receptor molecule of B lymphocytes

1989 • 149 citations

Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning.

1988 • 148 citations

Augmentation of normal and malignant B cell proliferation by monoclonal antibody to the B cell-specific antigen BP50 (CDW40).

1987 • 141 citations

B cell function in mice transgenic for mCTLA4-H gamma 1: lack of germinal centers correlated with poor affinity maturation and class switching despite normal priming of CD4+ T cells.

1994 • 136 citations

CD40 ligand is a T cell growth factor

1993 • 123 citations

Synergistic interaction between interleukin 4 and anti‐Bp50 (CDw40) revealed in a novel B cell restimulation assay

1987 • 68 citations

Deletions in the ligand for CD40 in X-linked immunoglobulin deficiency with normal or elevated IgM (HIGMX-1)

1993 • 67 citations