The Effect of 5-Lipoxygenase-Activating Protein (Flap) on Substrate Utilization by 5-Lipoxygenase

Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation

1983 • 2,839 citations

Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis

1990 • 777 citations

Translocation of 5-lipoxygenase to the membrane in human leukocytes challenged with ionophore A23187.

1988 • 323 citations

MK886, a potent and specific leukotriene biosynthesis inhibitor blocks and reverses the membrane association of 5-lipoxygenase in ionophore-challenged leukocytes.

1990 • 319 citations

Single protein from human leukocytes possesses 5-lipoxygenase and leukotriene A4 synthase activities.

1986 • 311 citations

5‐lipoxygenase‐activating protein is an arachidonate binding protein

1993 • 230 citations

5‐Lipoxygenase‐activating protein stimulates the utilization of arachidonic acid by 5‐lipoxygenase

1993 • 215 citations

Selenoenzymes regulate the activity of leukocyte 5-lipoxygenase via the peroxide tone.

1993 • 196 citations

5-Lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors

1992 • 129 citations

Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)-indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor

1992 • 112 citations

Characterization of the activity of purified recombinant human 5-lipoxygenase in the absence and presence of leukocyte factors.

1991 • 77 citations

Reversible membrane association of neutrophil 5-lipoxygenase is accompanied by retention of activity and a change in substrate specificity.

1992 • 65 citations

Translocation of HL-60 cell 5-lipoxygenase. Inhibition of A23187- or N-formyl-methionyl-leucyl-phenylalanine-induced translocation by indole and quinoline leukotriene synthesis inhibitors.

1991 • 49 citations

Stimulation of 5-lipoxygenase activity under conditions which promote lipid peroxidation

1989 • 47 citations

Stimulation of leukotriene production and membrane translocation of 5-lipoxygenase by cross-linking of the IgE receptors in RBL-2H3 cells

1992 • 43 citations