5-Lipoxygenase inhibitors for the treatment of inflammatory bowel disease

Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes

1980 • 2,099 citations

Leukotrienes and Other Products of the 5-Lipoxygenase Pathway

1990 • 1,216 citations

Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids

1980 • 925 citations

Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis

1990 • 777 citations

Enhanced Synthesis of Leukotriene B4 by Colonic Mucosa in Inflammatory Bowel Disease

1984 • 749 citations

The human PMN leukocyte chemotactic activity of complex hydroxy-eicosatetraenoic acids (HETEs).

1980 • 518 citations

Identification and isolation of a membrane protein necessary for leukotriene production

1990 • 464 citations

The Role of Arachidonic Acid Oxygenation Products in Pain and Inflammation

1984 • 457 citations

Selective Inhibitor of Slow Reacting Substance of Anaphylaxis

1973 • 443 citations

Slow reacting substances of anaphylaxis: Identification of leukotrienes C-1 and D from human and rat sources

1980 • 433 citations

MK886, a potent and specific leukotriene biosynthesis inhibitor blocks and reverses the membrane association of 5-lipoxygenase in ionophore-challenged leukocytes.

1990 • 319 citations

Leukotriene B: a potential mediator of inflammation

1980 • 303 citations

Endothelial cell leukotriene C4 synthesis results from intercellular transfer of leukotriene A4 synthesized by polymorphonuclear leukocytes.

1986 • 283 citations

Identification of the C(6)-S-conjugate of leukotriene a with cysteine as a naturally occurring slow reacting substance of anaphylaxis (SRS-A). Importance of the 11-cis-geometry for biological activity

1980 • 267 citations

Effects of topical 5-aminosalicylic acid and prednisolone on prostaglandin E2 and leukotriene B4 levels determined by equilibrium in vivo dialysis of rectum in relapsing ulcerative colitis

1986 • 266 citations

Introduction of a nomenclature: Leukotrienes

1979 • 257 citations

Sulfasalazine inhibits the synthesis of chemotactic lipids by neutrophils.

1982 • 227 citations

Characterization of the human 5-lipoxygenase gene.

1989 • 208 citations

In vivo profiles of eicosanoids in ulcerative colitis, Crohn's colitis, and Clostridium difficile colitis

1988 • 185 citations

Biosynthesis of lipoxygenase and cyclo-oxygenase products from [14C]-arachidonic acid by human colonic mucosa.

1983 • 176 citations

Alterations of the Immune System in Ulcerative Colitis and Crohn's Disease

1988 • 160 citations

Chemotactic activity in inflammatory bowel disease

1987 • 148 citations

Psoriasis

1988 • 143 citations

Treatment of Ulcerative Colitis with Fish Oil n-3-ω-Fatty Acid

1990 • 136 citations

Selective 5-lipoxygenase inhibition in ulcerative colitis

1990 • 135 citations

Effect of various lipoxygenase metabolites of arachidonic acid on degranulation of polymorphonuclear leukocytes.

1981 • 129 citations

Prostaglandin synthesis inhibitors in ulcerative colitis: Flurbiprofen compared with conventional treatment

1981 • 127 citations

Enhanced formation of sulfidopeptide-leukotrienes in ulcerative colitis and Crohn's disease: inhibition by sulfasalazine and 5-aminosalicylic acid

1986 • 116 citations

Propranolol in the prevention of recurrent variceal hemorrhage in cirrhotic patients

1990 • 107 citations

Studies of prostaglandins and sulphasalazine in ulcerative colitis

1981 • 105 citations

Role of Langerhans cells in epidermotropism of T cells

1988 • 102 citations

Therapeutic potential of fish oil in the treatment of ulcerative colitis

1989 • 97 citations

Inhibition of 5-lipoxygenase pathway of arachidonic acid metabolism in human neutrophils by sulfasalazine and 5-aminosalicylic acid

1987 • 92 citations

In vivo effects of orally administered prednisolone on prostaglandin and leucotriene production in ulcerative colitis.

1987 • 83 citations

Inhibition of soybean lipoxygenase by sulfasalazine and 5-aminosalicylic acid: a possible mode of action in ulcerative colitis

1983 • 72 citations

Eicosanoids and inflammatory bowel disease: Regulation and prospects for therapy

1990 • 62 citations

Inflammatory bowel diseases—Basic research and clinical implications

1989 • 60 citations

Leukotriene Receptor Antagonists as Potential Therapeutic Agents

1989 • 59 citations

Effects of sulfasalazine and a sulfasalazine analogue on the formation of lipoxygenase and cyclooxygenase products

1989 • 53 citations

Orally active hydroxamic acid inhibitors of leukotriene biosynthesis

1988 • 52 citations

Structure-activity analysis of a class of orally active hydroxamic acid inhibitors of leukotriene biosynthesis

1988 • 50 citations

Inflammatory intermediaries in inflammatory bowel disease

1989 • 49 citations

Hydroxyacetophenone-derived antagonists of the peptidoleukotrienes

1989 • 43 citations

Eicosanoids and their Role in the Pathogenesis of Diarrhoeal Diseases

1986 • 41 citations

2,3-Dihydro-5-benzofuranols as antioxidant-based inhibitors of leukotriene biosynthesis

1989 • 37 citations

Eicosanoids and rheumatology: Inflammatory and vascular aspects

1989 • 36 citations

Eicosanoids, epithelium and airway reactivity

1990 • 30 citations

Role of the 15‐Lipoxygenase in the Immune Systema

1988 • 28 citations

Biochemical Studies on Mammalian Lipoxygenases^a,^b

1988 • 24 citations

Single and multiple dose kinetics of clobazam, and clinical effects during multiple dosage

1984 • 24 citations

Eicosanoids as bioregulators in clinical medicine

1985 • 21 citations

Generation and recognition of leukotriene mediators of hypersensitivity and inflammation

1988 • 20 citations

Does Vitamin E Supplementation Modulate in Vivo Arachidonate Metabolism in Human Inflammation?

1987 • 17 citations

Receptor‐specific Mechanisms for the Responses of Human Leukocytes to Leukotrienesa

1988 • 16 citations

LEUKOTRIENE RECEPTORS AND SIGNAL TRANSDUCTION MECHANISM

1987 • 14 citations

Regulation of the Receptor System for Leukotriene B₄ on Human Neutrophilsa

1988 • 13 citations

Toward the Formulation of a Theory of Asthma

1990 • 11 citations

Perspectives on Additional Areas for Research in Leukotrienes

1988 • 9 citations

The role of eicosanoids in inflammatory bowel disease

1988 • 7 citations