Combined expression of multidrug resistance protein (MRP) and glutathione S-transferase P1-1 (GSTP1-1) in MCF7 cells and high level resistance to the cytotoxicities of ethacrynic acid but not oxazaphosphorines or cisplatin

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1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Glutathione S-Transferases

1974 • 17,321 citations

New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening

1990 • 9,412 citations

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues

1969 • 6,007 citations

The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I

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Basic Methods in Molecular Biology

1986 • 3,284 citations

Glutathione Transferases—Structure and Catalytic Activit

1988 • 1,751 citations

Glutathione-Associated Enzymes In Anticancer Drug Resistance

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The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.

1994 • 850 citations

Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells.

1994 • 777 citations

Identification of genetic polymorphisms at the glutathione S- transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer

1997 • 749 citations

Molecular Cloning, Characterization, and Expression in Escherichia coli of Full-length cDNAs of Three Human Glutathione S-Transferase Pi Gene Variants

1997 • 716 citations

Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.

1994 • 621 citations

Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump.

1996 • 569 citations

Multidrug Resistance Protein (MRP)-mediated Transport of Leukotriene C4 and Chemotherapeutic Agents in Membrane Vesicles

1996 • 555 citations

Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance.

1993 • 517 citations

The Role of Glutathione and Glutathione Transferases in Chemical Cardnogenesi

1990 • 466 citations

ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein.

1994 • 435 citations

Detoxication of base propenals and other alpha,beta-unsaturated aldehyde products of radical reactions and lipid peroxidationby human glutathione transferases.

1994 • 412 citations

Glutathione S-transferases and drug resistance

1991 • 299 citations

Coordinated Induction of / Pump and γ-Glutamylcysteine Synthetase by Heavy Metals in Human Leukemia Cells

1996 • 264 citations

Multidrug resistance-associated protein gene overexpression and reduced drug sensitivity of topoisomerase II in a human breast carcinoma MCF7 cell line selected for etoposide resistance.

1994 • 248 citations

Glutathione conjugate mediated toxicities*1

1990 • 228 citations

Expression of multidrug resistance-associated protein in NIH/3T3 cells confers multidrug resistance associated with increased drug efflux and altered intracellular drug distribution.

1995 • 208 citations

GS-X pump is functionally overexpressed in cis-diamminedichloroplatinum (II)-resistant human leukemia HL-60 cells and down-regulated by cell differentiation.

1994 • 204 citations

Detection of the M(r) 190,000 multidrug resistance protein, MRP, with monoclonal antibodies.

1994 • 196 citations

Transfection of glutathione S-transferase (GST)-pi antisense complementary DNA increases the sensitivity of a colon cancer cell line to adriamycin, cisplatin, melphalan, and etoposide.

1996 • 187 citations

Acrolein-induced oxygen radical formation

1993 • 182 citations

Elevation of pi class glutathione S-transferase activity in human breast cancer cells by transfection of the GST pi gene and its effect on sensitivity to toxins.

1989 • 164 citations

Involvement of human glutathione S-transferase isoenzymes in the conjugation of cyclophosphamide metabolites with glutathione.

1994 • 161 citations

Inhibition of rat and human glutathione S-transferase isoenzymes by ethacrynic acid and its glutathione conjugate

1990 • 160 citations

Phase I study of thiotepa in combination with the glutathione transferase inhibitor ethacrynic acid.

1991 • 143 citations

The role of glutathione-dependent enzymes in drug resistance

1991 • 142 citations

Isolation of the human anionic glutathione S-transferase cDNA and the relation of its gene expression to estrogen-receptor content in primary breast cancer.

1988 • 134 citations

Glutathione S-transferase (transferase π) from human placenta is identical or closely related to glutathione S-transferase (transferase ϱ) from erythrocytes

1981 • 119 citations

Glutathione S—transferase and drug resistance

1989 • 90 citations

Reversible conjugation of ethacrynic acid with glutathione and human glutathione S-transferase P1-1.

1994 • 82 citations

Ethacrynic acid and its glutathione conjugate as inhibitors of glutathioneS-transferases

1993 • 81 citations

Augmentation of transport for cisplatin-glutathione adduct in cisplatin-resistant cancer cells.

1995 • 79 citations

Multidrug resistance protein and glutathione S-transferase P1-1 act in synergy to confer protection from 4-nitroquinoline 1-oxide toxicity

1998 • 73 citations

Transport of the glutathione conjugate of ethacrynic acid by the human multidrug resistance protein MRP

1996 • 73 citations

Antineoplastic drug sensitivity of human MCF-7 breast cancer cells stably transfected with a human alpha class glutathione S-transferase gene.

1991 • 69 citations

Expression of human mu or alpha class glutathione S-transferases in stably transfected human MCF-7 breast cancer cells: effect on cellular sensitivity to cytotoxic agents.

1992 • 65 citations

Significance of an unusually lowK_mfor glutathione in glutathione transferases of the α μ and π classes

1993 • 64 citations

Drug resistance to cis-diamminedichloroplatinum(II) in chinese hamster ovary cell lines transfected with glutathione S-transferase pi gene

1990 • 62 citations

Glutathione Conjugation of the Cytostatic Drug Ifosfamide and the Role of Human Glutathione S-Transferases

1995 • 58 citations

Increased levels of glutathione S-transferase π transcript as a mechanism of resistance to ethacrynic acid

1992 • 48 citations

Studies on the Basis for the Toxicity of Acrolein Mercapturates

1996 • 48 citations

Chlorambucil-monoglutathionyl conjugate is sequestered by human alpha class glutathione S-transferases

1992 • 45 citations

Protection by transfected glutathione S-transferase isozymes against carcinogen-induced alkylation of cellular macromolecules in human MCF-7 cells

1994 • 45 citations

Effects of Chronic Ethacrynic Acid Exposure on Glutathione Conjugation and MRP Expression in Human Colon Tumor Cells

1996 • 31 citations

The interaction of glutathione with 4-hydroxycyclophosphamide and phosphoramide mustard, studied by 31P nuclear magnetic resonance spectroscopy

1994 • 26 citations

Biosynthesis, bioactivation, and mutagenicity of S-conjugates

1990 • 23 citations

Biosynthesis and Cellular Effects of Toxic Glutathione S-Conjugates

1996 • 9 citations