The interaction of glutathione with 4-hydroxycyclophosphamide and phosphoramide mustard, studied by 31P nuclear magnetic resonance spectroscopy

Glutathione S-transferases: role in alkylating agent resistance and possible target for modulation chemotherapy--a review.

1990 • 259 citations

The role of glutathione-dependent enzymes in drug resistance

1991 • 142 citations

Oxazaphosphorine cytostatics: past-present-future. Seventh Cain Memorial Award lecture.

1989 • 111 citations

The problem of specificity and selectivity of alkylating cytostatics; studies on N-2-chloroethylamido-oxazaphosphorines

1977 • 108 citations

Glutathione conjugation with phosphoramide mustard and cyclophosphamide. A mechanistic study using tandem mass spectrometry.

1991 • 63 citations

Glutathione conjugates. Immobilized enzyme synthesis and characterization by fast atom bombardment mass spectrometry.

1986 • 60 citations

NMR spectroscopic studies of intermediary metabolites of cyclophosphamide. A comprehensive kinetic analysis of the interconversion of cis- and trans-4-hydroxycyclophosphamide with aldophosphamide and the concomitant partitioning of aldophosphamide between irreversible fragmentation and reversible conjugation pathways

1984 • 50 citations

Glutathione S-transferase in chemotherapy resistance and in carcinogenesis

1992 • 43 citations

Historical aspects of glutathione and cancer chemotherapy

1991 • 40 citations

Deactivation of cyclophosphamide (NSC-26271) metabolites by sulfhydryl compounds.

1976 • 36 citations

Kinetics of Phosphoramide Mustard Hydrolysis in Aqueous Solution

1985 • 34 citations

Phosphorus-31 NMR studies of the kinetics of bisalkylation by isophosphoramide mustard: comparisons with phosphoramide mustard

1989 • 30 citations

Phosphorus-31 NMR kinetic studies of the intra- and intermolecular alkylation chemistry of phosphoramide mustard and cognate N-phosphorylated derivatives of N,N-bis(2-chloroethyl)amine

1982 • 30 citations

Activation mechanisms of mafosfamide and the role of thiols in cyclophosphamide metabolism

1987 • 29 citations

Glutathione diminishes the anti-tumour activity of 4-hydroperoxycyclophosphamide by stabilising its spontaneous breakdown to alkylating metabolites

1991 • 27 citations

Synthesis and preliminary antitumor evaluation of 4-(SR)-sulfido-cyclophosphamides

1979 • 27 citations

Iminocyclophosphamide as a chemically reactive metabolite of cyclophosphamide.

1982 • 25 citations