Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

1992 • 2,293 citations

Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression

1995 • 1,863 citations

Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity

1995 • 1,608 citations

The extracellular matrix as a cell survival factor.

1993 • 1,541 citations

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

1993 • 1,470 citations

Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer.

1995 • 1,271 citations

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb

1996 • 980 citations

Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.

1995 • 766 citations

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody

1996 • 718 citations

Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis.

1995 • 598 citations

Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells.

1994 • 504 citations

Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis.

1993 • 502 citations

Stabilization of Vascular Endothelial Growth Factor mRNA by Hypoxia and Hypoglycemia and Coregulation with Other Ischemia-Induced Genes

1995 • 453 citations

Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression.

1994 • 453 citations

Intermittent blood flow in a murine tumor: radiobiological effects.

1987 • 440 citations

Dominant-negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo.

1996 • 423 citations

Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression.

1995 • 409 citations

Exogenous vascular endothelial growth factor induces malformed and hyperfused vessels during embryonic neovascularization.

1995 • 338 citations

Both v-Ha-Ras and v-Raf Stimulate Expression of the Vascular Endothelial Growth Factor in NIH 3T3 Cells

1995 • 336 citations

Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: novel concepts of angiostatic therapy from intravital videomicroscopy.

1996 • 336 citations

Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas.

1995 • 329 citations

Integrins, adhesion and apoptosis

1997 • 274 citations

Enhancement of Tumor Growth and Vascular Density by Transfection of Vascular Endothelial Cell Growth Factor Into MCF-7 Human Breast Carcinoma Cells

1995 • 270 citations

Angiostatin: A Circulating Endothelial Cell Inhibitor That Suppresses Angiogenesis and Tumor Growth

1994 • 219 citations

Relationship of endothelial cell proliferation to tumor vascularity in human breast cancer.

1993 • 209 citations

The use of fluorescent probes to identify regions of transient perfusion in murine tumors

1989 • 173 citations

Programmed cell death and the control of cell survival

1994 • 169 citations

Cyclic angiogenesis and blood vessel regression in the ovary: blood vessel regression during luteolysis involves endothelial cell detachment and vessel occlusion.

1996 • 136 citations

Expression of Growth Factors and Growth Factor Receptors in Capillary Hemangioblastoma

1996 • 92 citations

Expression of Vascular Endothelial Growth Factor in Capillary Hemangioblastoma

1993 • 86 citations

Treating cancer by inhibiting angiogenesis: new hopes and potential pitfall

1996 • 69 citations

Proliferative potential of vascular components in human glioblastoma multiforme

1987 • 26 citations

Regulation of Basic Fibroblast Growth Factor mRNA Expression in Rat C6 Glioma Cells

1993 • 22 citations