Rapid Induction of Long-Lasting Drug Efflux Activity in Brain Vascular Endothelial Cells But Not Malignant Glioma Following Irradiation

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Fluorescent cellular indicators are extruded by the multidrug resistance protein.

1993 • 496 citations

The physiological function of drug-transporting P-glycoproteins

1997 • 457 citations

Calcein accumulation as a fluorometric functional assay of the multidrug transporter

1994 • 316 citations

Mrp1 Multidrug Resistance‐Associated Protein and P‐Glycoprotein Expression in Rat Brain Microvessel Endothelial Cells

1998 • 265 citations

Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance.

2000 • 196 citations

Permeability Characteristics of Brain Adjacent to Tumors in Rats

1975 • 165 citations

A critique of the role of the blood-brain barrier in the chemotherapy of human brain tumors

1994 • 133 citations

Overexpression of P-glycoprotein in Mammalian Tumor Cell Lines After Fractionated X Irradiation In Vitro

1990 • 118 citations

Interaction of drugs with P-glycoprotein in brain capillaries

1995 • 100 citations

Genetic aspects of multidrug resistance

1992 • 77 citations

Increase in doxorubicin cytotoxicity by carvedilol inhibition of P-glycoprotein activity

1999 • 59 citations

Microfluorometric Evaluation of Calcein Acetoxymethyl Ester as a Probe for P-Glycoprotein-Mediated Resistance: Effects of Cyclosporin A and Its Nonimmunosuppressive Analogue SDZ PSC 833

1994 • 57 citations

Ultrastructural localization of P-glycoprotein on capillary endothelial cells in human gliomas

1994 • 53 citations

Multidrug resistance-reversing agents increase vinblastine distribution in normal tissues expressing the P-glycoprotein but do not enhance drug penetration in brain and testis.

1997 • 52 citations

Radiation therapy of 9L rat brain tumors

1981 • 52 citations

Effects of radiotherapy and estramustine on the microvasculature in malignant glioma

1999 • 38 citations

Murine P-glycoprotein on stromal vessels mediates multidrug resistance in intracerebral human glioma xenografts

1997 • 37 citations

Expression of P-glycoprotein, a multidrug-resistance gene product, is Induced by radiotherapy in patients with oral squamous cell carcinoma

1998 • 37 citations

Parallel functional and immunological detection of human multidrug resistance proteins, P-glycoprotein and MRP1.

1998 • 28 citations

Evidence of post-translational regulation of P-glycoprotein associated with the expression of a distinctive multiple drug-resistant phenotype in Chinese hamster ovary cells

1993 • 27 citations

CYTOTOXIC EFFECT AND UPTAKE OF ESTRAMUSTINE IN A RAT GLIOMA MODEL

1994 • 27 citations

Bilateral irradiation of head and neck induces an enhanced expression of substance p in the parasympathetic innervation of the submandibular gland

1992 • 27 citations

Decreased delivery and acute toxicity of cranial irradiation and chemotherapy given with osmotic blood-brain barrier disruption in a rodent model: the issue of sequence.

1995 • 26 citations

Time- and dose-related changes in the expression of substance P in salivary glands in response to fractionated irradiation

1995 • 24 citations

Does P-glycoprotein play a role in clinical resistance of malignant astrocytoma?

1999 • 23 citations

Irradiation-induced effects on the innervation of rat salivary glands: Changes in enkephalin- and bombesin-like immunoreactivity in ganglionic cells and intraglandular nerve fibers

1993 • 21 citations

Identification of a distinctive p-glycoprotein-mediated resistance phenotype in human ovarian carcinoma cells after their in vitro exposure to fractionated x-irradiation

1994 • 21 citations

Radiosensitizing effect of estramustine in malignant gliomain vitro andin vivo

1995 • 18 citations

Enhanced Expression of Neuropeptides in Human Breast Cancer Cell Lines Following Irradiation

1998 • 15 citations

Does Bombesin-like Peptide Mediate Radiation-induced Anorexia and Satiety?

1999 • 7 citations