CD95 Expression and Apoptosis during Pediatric HIV Infection: Early Upregulation of CD95 Expression

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.

1989 • 1,436 citations

Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes

1995 • 951 citations

Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals.

1992 • 907 citations

Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen.

1992 • 857 citations

The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen.

1992 • 839 citations

Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis.

1992 • 689 citations

Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood.

1992 • 510 citations

Programmed cell death in peripheral lymphocytes from HIV-infected persons: increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression.

1996 • 499 citations

Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals.

1995 • 438 citations

Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1.

1991 • 432 citations

DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement

1992 • 392 citations

Analysis of apoptosis in lymph nodes of HIV-infected persons. Intensity of apoptosis correlates with the general state of activation of the lymphoid tissue and not with stage of disease or viral burden.

1995 • 386 citations

Apoptosis in AIDS

1993 • 375 citations

Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen

1990 • 375 citations

The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory.

1993 • 350 citations

T helper type 1/T helper type 2 cytokines and T cell death: preventive effect of interleukin 12 on activation-induced and CD95 (FAS/APO-1)-mediated apoptosis of CD4+ T cells from human immunodeficiency virus-infected persons.

1995 • 283 citations

Anergy and apoptosis in CD8+ T cells from HIV-infected persons.

1994 • 252 citations

Accelerated apoptosis in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus type-1 infected patients and in CD4 cross-linked PBMCs from normal individuals

1993 • 242 citations

Cross-linking of CD4 molecules upregulates Fas antigen expression in lymphocytes by inducing interferon-gamma and tumor necrosis factor- alpha secretion

1994 • 220 citations

The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis

1994 • 210 citations

Membrane Expression of HIV Envelope Glycoproteins Triggers Apoptosis in CD4 Cells

1993 • 210 citations

Accelerated apoptosis in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus type-1 infected patients and in CD4 cross-linked PBMCs from normal individuals

1993 • 197 citations

Fas-mediated apoptosis of CD4+ and CD8+ T cells from human immunodeficiency virus-infected persons: differential in vitro preventive effect of cytokines and protease antagonists

1996 • 189 citations

Natural History of Human Immunodeficiency Virus Disease in Perinatally Infected Children: An Analysis From the Pediatric Spectrum of Disease Project

1996 • 171 citations

Programmed cell death and AIDS: from hypothesis to experiment

1992 • 167 citations

Programmed death of T cells in human immunodeficiency virus infection. No correlation with progression to disease.

1994 • 152 citations

Activation of the CD95 (APO-1/Fas) system in T cells from human immunodeficiency virus type-1-infected children

1996 • 150 citations

The Fas receptor in HIV infection

1996 • 126 citations

IL-2 rescues in vitro lymphocyte apoptosis in patients with HIV infection: correlation with its ability to block culture-induced down-modulation of Bcl-2.

1996 • 119 citations

Overexpression of Fas antigen on T cells in advanced HIV-1 infection: differential ligation constantly induces apoptosis

1996 • 100 citations

CD4 engagement induces Fas antigen‐dependent apoptosis of T cells in vivo

1994 • 98 citations

Apoptosis induced in CD4+ cells expressing gp160 of human immunodeficiency virus type 1

1994 • 89 citations

Modulation of Bcl-2 Protein by CD4 Cross-Linking: A Possible Mechanism for Lymphocyte Apoptosis in Human Immunodeficiency Virus Infection and for Rescue of Apoptosis by Interleukin-2

1997 • 85 citations

Expression of the fas antigen in patients infected with human immunodeficiency virus

1995 • 85 citations

Fas (CD95) expression on CD4+ T cells from HIV-infected patients increases with disease progression

1995 • 71 citations

Pathogenesis of Pediatric Human Immunodeficiency Virus Type 1 Infection

1994 • 52 citations

Use of a Flow Cytometric Assay to Quantitate Apoptosis in Human Lymphocytes

1994 • 49 citations

Differential Expression of Fas Antigen and Bcl-2 Protein on CD4+ T Cells, CD8+ T Cells, and Monocytes

1995 • 48 citations

Progression of human immunodeficiency virus disease among infants and children infected perinatally with human immunodeficiency virus or through neonatal blood transfuion

1994 • 46 citations

Functional significance of the Fas molecule in naive lymphocytes

1996 • 28 citations

Apoptosis in HIV-Infected Individuals Is an Early Marker Occurring Independently of High Viremia

1997 • 24 citations

T-cell death by apoptosis in vertically human immunodeficiency virus- infected children coincides with expansion of CD8+/interleukin-2 receptor-/HLA-DR+ T cells: sign of a possible role for herpes viruses as cofactors?

1995 • 21 citations

Modulation of Bcl-2 Protein by CD4 Cross-Linking: A Possible Mechanism for Lymphocyte Apoptosis in Human Immunodeficiency Virus Infection and for Rescue of Apoptosis by Interleukin-2

1997 • 17 citations

Activation-Induced Death by Apoptosis in CD4 T Cells from HIV-Infected Asymptomatic Individuals

1991 • 16 citations

Maternal Transmission and Diagnosis of Human Immunodeficiency Virus during Infancy

1993 • 11 citations

Epidemiology of Pediatric Human Immunodeficiency Virus Infection in the United States

1993 • 8 citations

Direct involvement of extracellular HIV-1 virions in the apoptosis of CD8+ lymphocytes: A two-step model

1994 • 5 citations