Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase

1994 • 1,026 citations

Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells

2006 • 893 citations

Mitochondrial Dysfunction in Atherosclerosis

2007 • 708 citations

NADPH Oxidases, Reactive Oxygen Species, and Hypertension

2008 • 675 citations

Oscillatory and Steady Laminar Shear Stress Differentially Affect Human Endothelial Redox State

1998 • 607 citations

Advances in measuring cellular bioenergetics using extracellular flux

2008 • 422 citations

Mitochondrial dysfunction in cardiovascular disease

2005 • 394 citations

Reactive Oxygen Species Production by Mitochondria

2009 • 337 citations

Quantitative Microplate-Based Respirometry with Correction for Oxygen Diffusion

2009 • 310 citations

On the mechanism by which vascular endothelial cells regulate their oxygen consumption

1999 • 300 citations

Oscillatory Shear Stress Stimulates Endothelial Production of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si1.gif"><mml:msubsup><mml:mi mathvariant="normal">O</mml:mi><mml:mrow><mml:mn>2</mml:mn></mml:mrow><mml:mo>-</mml:mo></mml:msubsup></mml:math> from p47 -dependent NAD(P)H Oxidases, Leading to Monocyte Adhesion

2003 • 298 citations

Direct evidence for S-nitrosation of mitochondrial complex I

2006 • 271 citations

Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal

2009 • 271 citations

Regulation of hypoxia-inducible factor-1α by nitric oxide through mitochondria-dependent and -independent pathways

2003 • 257 citations

The proton leak across the mitochondrial inner membrane

1990 • 249 citations

Rapid reduction of nitric oxide by mitochondria, and reversible inhibition of mitochondrial respiration by nitric oxide

1996 • 243 citations

Redox Signaling, Vascular Function, and Hypertension

2008 • 233 citations

Nitric oxide is consumed, rather than conserved, by reaction with oxyhemoglobin under physiological conditions

2002 • 213 citations

Nitric oxide partitioning into mitochondrial membranes and the control of respiration at cytochrome c oxidase

2001 • 211 citations

Inhibition of cytochrome c oxidase in turnover by nitric oxide: mechanism and implications for control of respiration

1995 • 207 citations

Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure

2009 • 195 citations

A Role for Reactive Oxygen Species in Endothelial Cell Anoikis

1999 • 195 citations

On the mechanism and biology of cytochrome oxidase inhibition by nitric oxide

2004 • 188 citations

Nanotransducers in cellular redox signaling: modification of thiols by reactive oxygen and nitrogen species

2002 • 183 citations

Control of respiration and oxidative phosphorylation in isolated rat liver cells

1990 • 171 citations

Nitric oxide regulation of mitochondrial oxygen consumption II: molecular mechanism and tissue physiology

2007 • 168 citations

Mitochondria, nitric oxide, and cardiovascular dysfunction

2002 • 149 citations

In Situ Respiration and Bioenergetic Status of Mitochondria in Primary Cerebellar Granule Neuronal Cultures Exposed Continuously to Glutamate

2004 • 143 citations

Control of Mitochondrial Respiration by NO., Effects of Low Oxygen and Respiratory State

2003 • 116 citations

Kinetic modelling of the nitric oxide gradient generated in vitro by adherent cells expressing inducible nitric oxide synthase

1996 • 109 citations

Nitric Oxide Modulates Mitochondrial Respiration in Failing Human Heart

1999 • 106 citations

Autoxidation of extracellular hydroquinones is a causative event for the cytotoxicity of menadione and DMNQ in A549-S cells

2003 • 103 citations

Nitric oxide inhibits H ₂ O ₂ -induced transferrin receptor-dependent apoptosis in endothelial cells: Role of ubiquitin-proteasome pathway

2003 • 97 citations

Theoretical studies on the control of oxidative phosphorylation in muscle mitochondria: application to mitochondrial deficiencies

1996 • 91 citations

Alterations in zinc homeostasis underlie endothelial cell death induced by oxidative stress from acute exposure to hydrogen peroxide

2006 • 88 citations

Dynamic regulation of metabolism and respiration by endogenously produced nitric oxide protects against oxidative stress

2001 • 82 citations

Regulation of vascular smooth muscle cell bioenergetic function by protein glutathiolation

2009 • 82 citations

Understanding Nitric Oxide Physiology in the Heart: A Nanomedical Approach

2005 • 81 citations

Chronic exposure to nitric oxide alters the free iron pool in endothelial cells: Role of mitochondrial respiratory complexes and heat shock proteins

2003 • 65 citations

Inhibition of mitochondrial protein synthesis results in increased endothelial cell susceptibility to nitric oxide-induced apoptosis

2002 • 60 citations

The leaks and slips of bioenergetic membranes

1992 • 53 citations

Competitive, Reversible, Physiological? Inhibition of Mitochondrial Cytochrome Oxidase by Nitric Oxide

2003 • 46 citations

Dynamics of nitric oxide release in the cardiovascular system.

2003 • 41 citations

Reversible inhibition of cellular respiration by nitric oxide in vascular inflammation

2001 • 41 citations

Activation of c-Jun N-Terminal Kinase and Apoptosis in Endothelial Cells Mediated by Endogenous Generation of Hydrogen Peroxide

2002 • 37 citations

Relative sensitivity of soluble guanylate cyclase and mitochondrial respiration to endogenous nitric oxide at physiological oxygen concentration

2007 • 32 citations

Nitric oxide mitigates peroxide-induced iron-signaling, oxidative damage, and apoptosis in endothelial cells: role of proteasomal function?

2004 • 21 citations

Simulation of state 4 → state 3 transition in isolated mitochondria

1996 • 13 citations