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Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

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Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells

2006 • 893 citations

Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the Heart

2008 • 729 citations

A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling

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Reduced Mitochondrial Oxidative Capacity and Increased Mitochondrial Uncoupling Impair Myocardial Energetics in Obesity

2005 • 483 citations

Decrease in Mitochondrial Complex I Activity in Ischemic/Reperfused Rat Heart

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Advances in measuring cellular bioenergetics using extracellular flux

2008 • 422 citations

Overexpression of MnSOD Protects Against Myocardial Ischemia/reperfusion Injury in Transgenic Mice

1998 • 351 citations

Selective Inactivation of α-Ketoglutarate Dehydrogenase and Pyruvate Dehydrogenase: Reaction of Lipoic Acid with 4-Hydroxy-2-nonenal

1998 • 350 citations

Carvedilol Decreases Elevated Oxidative Stress in Human Failing Myocardium

2002 • 282 citations

Spare Respiratory Capacity Rather Than Oxidative Stress Regulates Glutamate Excitotoxicity after Partial Respiratory Inhibition of Mitochondrial Complex I with Rotenone

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1985 • 264 citations

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Metabolism of the Lipid Peroxidation Product, 4-Hydroxy-trans-2-nonenal, in Isolated Perfused Rat Heart

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Inhibition of NADH-Linked Mitochondrial Respiration by 4-Hydroxy-2-nonenal

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Oxidatively damaged proteins of heart mitochondrial electron transport complexes

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Transgenic Mice Overexpressing Glutathione Peroxidase are Resistant to Myocardial Ischemia Reperfusion Injury

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4-Hydroxynonenal Induces Apoptosis via Caspase-3 Activation and CytochromecRelease

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Role of 4-Hydroxynonenal in Modification of Cytochrome c Oxidase in Ischemia/Reperfused Rat Heart

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Targeted Disruption of the Mouse Sod I Gene Makes the Hearts Vulnerable to Ischemic Reperfusion Injury

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Glutathione peroxidase knockout mice are susceptible to myocardial ischemia reperfusion injury.

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Accumulation of 15-deoxy-Δ12,14-prostaglandin J2 adduct formation with Keap1 over time: effects on potency for intracellular antioxidant defence induction

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Unsaturated aldehydes including 4-OH-nonenal are elevated in patients with congestive heart failure

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Stimulation of mitochondrial proton conductance by hydroxynonenal requires a high membrane potential

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Myocardial ischaemia inhibits mitochondrial metabolism of 4-hydroxy-trans-2-nonenal

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Reduced cardiac output is associated with decreased mitochondrial efficiency in the non-ischemic ventricular wall of the acute myocardial-infarcted dog

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Cardiac energetics in clinical heart disease

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