Differential regulation of IFN‐γ, IL‐10 and inducible nitric oxide synthase in human T cells by cyclic AMP‐dependent signal transduction pathway

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Lymphokine Production by Human T Cells in Disease States

1994 • 1,351 citations

Nitric oxide synthase: Aspects concerning structure and catalysis

1994 • 865 citations

Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines.

1991 • 835 citations

Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow‐derived macrophages by TH 1 and TH 2 cytokines

1995 • 553 citations

Nitric oxide and asthmatic inflammation

1995 • 514 citations

Restoration of Several Morphological Characteristics of Normal Fibroblasts in Sarcoma Cells Treated with Adenosine-3′:5′-Cyclic Monophosphate and Its Derivatives

1971 • 440 citations

Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-γ in murine macrophages

1992 • 384 citations

Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells

1994 • 377 citations

Up-regulation of monocytic IL-10 by tumor necrosis factor-α and cAMP elevating drugs

1995 • 318 citations

Cholera toxin discriminates between T helper 1 and 2 cells in T cell receptor-mediated activation: role of cAMP in T cell proliferation.

1990 • 238 citations

A possible novel pathway of regulation by murine T helper type‐2 (T_h2) cells of a T_h1 cell activity via the modulation of the induction of nitric oxide synthase on macrophages

1991 • 226 citations

cAMP inhibits induction of interleukin 2 but not of interleukin 4 in T cells.

1990 • 218 citations

Phosphodiesterase inhibitor pentoxifylline, a selective suppressor of T helper type 1‐ but not type 2‐associated lymphokine production, prevents induction of experimental autoimmune encephalomyelitis in Lewis rats

1993 • 168 citations

Two distinct signaling pathways trigger the expression of inducible nitric oxide synthase in rat renal mesangial cells.

1994 • 164 citations

Induction of nitric oxide synthase by cyclic AMP in rat vascular smooth muscle cells.

1994 • 152 citations

Rise and Fall of Cyclic AMP Required for Onset of Lymphocyte DNA Synthesis

1978 • 151 citations

Prostaglandin E2 promotes B lymphocyte Ig isotype switching to IgE.

1995 • 137 citations

Altered prostaglandin E2 regulation of cytokine production in atopic dermatitis.

1993 • 133 citations

Interleukin (IL)‐4 production by human T cells: differential regulation of IL‐4 vs. IL‐2 production

1992 • 126 citations

Modulation of AP‐1 activity by nitric oxide (NO) in vitro: NO‐mediated modulation of AP‐1

1994 • 109 citations

IL-10 is involved in the protective effect of dibutyryl cyclic adenosine monophosphate on endotoxin-induced inflammatory liver injury.

1995 • 96 citations

cAMP activates the IL-5 promoter synergistically with phorbol ester through the signaling pathway involving protein kinase A in mouse thymoma line EL-4.

1993 • 92 citations

Early activation signal transduction pathways of Th1 and Th2 cell clones stimulated with anti-CD3. Roles of protein tyrosine kinases in the signal for IL-2 and IL-4 production.

1995 • 68 citations

Differential spontaneous expression of mRNA for IL-4, IL-10, IL-13, IL-2 and interferon-gamma (IFN-γ) in peripheral blood mononuclear cells (PBMC) from atopic patients

1996 • 68 citations

Studies on the cyclic AMP response to prostaglandin in human lymphocytes

1981 • 65 citations

Tyrosine kinases are involved with the expression of inducible nitric oxide synthase in human articular chondrocytes

1995 • 49 citations

Regulatory Effects of Pentoxifylline on T-Helper Cell-Derived Cytokine Production in Human Blood Cells

1995 • 43 citations

Pentamethyl-hydroxychromane, vitamin E derivative, inhibits induction of nitric oxide synthase by bacterial lipopolysaccharide.

1995 • 31 citations

Depressed lymphocyte transformation and the role of prostaglandins in atopic dermatitis

1990 • 25 citations

Lack of inducible nitric oxide synthase activity in T cell clones and T lymphocytes from naive and Leishmania major‐infected mice

1995 • 24 citations

Altered Leukocyte Protein Kinase Activity in Atopic Dermatitis

1988 • 23 citations

Antisense oligonucleotides to interleukin‐4 regulate IgE and IgG2a production by spleen cells from Nippostrongylus brasiliensis‐infected rats

1993 • 19 citations

Regulation of expression of the IL-2 and IL-5 genes and the role of proteins related to nuclear factor of activated T cells

1995 • 14 citations