Phosphodiesterase inhibitor pentoxifylline, a selective suppressor of T helper type 1‐ but not type 2‐associated lymphokine production, prevents induction of experimental autoimmune encephalomyelitis in Lewis rats

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Handbook of clinical neurology

1986 • 1,951 citations

Pentoxifylline

1987 • 1,768 citations

The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome.

1989 • 1,183 citations

Heterogeneity of Cytokine Secretion Patterns and Functions of Helper T Cells

1989 • 1,122 citations

The T Lymphocyte in Experimental Allergic Encephalomyelitis

1990 • 1,005 citations

Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines.

1991 • 835 citations

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain.

1992 • 726 citations

Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens.

1988 • 713 citations

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

1990 • 692 citations

Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxofylline

1988 • 564 citations

Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages.

1990 • 511 citations

Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway.

1990 • 509 citations

Heterogeneity of mouse helper T cells. Evidence from bulk cultures and limiting dilution cloning for precursors of Th1 and Th2 cells.

1990 • 386 citations

Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity

1990 • 285 citations

OXPENTIFYLLINE IN ENDOTOXAEMIA

1989 • 263 citations

Synthesis of interleukin 6 (interferon-beta 2/B cell stimulatory factor 2) in human fibroblasts is triggered by an increase in intracellular cyclic AMP.

1988 • 261 citations

Cholera toxin discriminates between T helper 1 and 2 cells in T cell receptor-mediated activation: role of cAMP in T cell proliferation.

1990 • 238 citations

Homing to central nervous system vasculature by antigen-specific lymphocytes. I. Localization of 14C-labeled cells during acute, chronic, and relapsing experimental allergic encephalomyelitis.

1990 • 234 citations

MS: a CNS and systematic autoimmune disease

1989 • 231 citations

cAMP inhibits induction of interleukin 2 but not of interleukin 4 in T cells.

1990 • 218 citations

Evidence implicating utilization of different T cell receptor-associated signaling pathways by TH1 and TH2 clones.

1990 • 218 citations

Effect of Pentoxifylline on the Phagocytic Activity, cAMP Levels, and Superoxide Anion Production by Monocytes and Polymorphonuclear Cells

1986 • 214 citations

Interleukin-HP1, a T cell-derived hybridoma growth factor that supports the in vitro growth of murine plasmacytomas.

1987 • 174 citations

Evidence for differential induction of helper T cell subsets during Trichinella spiralis infection.

1989 • 138 citations

Acute experimental allergic encephalomyelitis in the mouse: Immunopathology of the developing lesion

1985 • 134 citations

MHC control of CD4+ T cell subset activation.

1989 • 121 citations

ARDS, Neutrophils, and Pentoxifylline

1988 • 120 citations

The immunopathology of experimental allergic encephalomyelitis. I. Quantitative analysis of inflammatory cells in situ.

1984 • 111 citations

Immunohistological analysis of macrophages in the central nervous system of Lewis rats with acute experimental allergic encephalomyelitis

1986 • 102 citations

Evidence for functional heterogeneity of rat CD4+ T cells in vivo. Differential expression of IL-2 and IL-4 mRNA in recipients of cardiac allografts.

1992 • 88 citations

MS: a localized immune disease of the central nervous system

1989 • 72 citations

Effects of anti-proliferative cyclic AMP on interleukin 2-stimulated gene expression.

1987 • 57 citations

Protection from experimental allergic encephalomyelitis by application of a bacterial superantigen

1992 • 49 citations

Lectin-mediated induction of IL-4-producing CD4+ T cells.

1991 • 48 citations

The effect of pentoxifylline in septic shock--new pharmacologic aspects of an established drug.

1989 • 44 citations

Prostacyclin production of rat aorta “in vitro” is increased by the combined action of dipyridamole plus pentoxifylline

1985 • 8 citations