Antisense oligonucleotides to interleukin‐4 regulate IgE and IgG2a production by spleen cells from Nippostrongylus brasiliensis‐infected rats

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Lymphokine Control of In Vivo Immunoglobulin Isotype Selection

1990 • 1,303 citations

Specific regulation of gene expression by antisense, sense and antigene nucleic acids

1990 • 769 citations

Phosphorothioate analogs of oligodeoxynucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus.

1987 • 530 citations

Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities.

1986 • 529 citations

Oligonucleotide synthesis: A practical approach

1985 • 493 citations

Oligonucleotide synthesis : a practical approach

1984 • 491 citations

An oligomer complementary to c-myc mRNA inhibits proliferation of HL-60 promyelocytic cells and induces differentiation.

1988 • 476 citations

Immune responses in vitro. I. Culture conditions for antibody synthesis

1972 • 426 citations

Human promyelocytic leukemia HL-60 cell proliferation and c-myc protein expression are inhibited by an antisense pentadecadeoxynucleotide targeted against c-myc mRNA.

1988 • 374 citations

Sequence‐dependent hydrolysis of RNA using modified oligonucleotide splints and RNase H

1987 • 261 citations

Inhibition of human immunodeficiency virus replication by antisense oligodeoxynucleotides.

1988 • 227 citations

Molecular cloning of rat interleukin 4 cDNA and analysis of the cytokine repertoire of subsets of CD4⁺ T cells

1991 • 218 citations

The Subclass Nature and Clinical Significance of the IgG Antibody Response in Patients Undergoing Allergen‐Specific Immunotherapy

1985 • 210 citations

Elevation of total serum IgE in rats following helminth parasite infection

1974 • 174 citations

Interleukin-6 antisense oligonucleotides inhibit the growth of human myeloma cell lines.

1991 • 123 citations

Infection with Nippostrongylus brasiliensis or injection of anti-IgD antibodies markedly enhances Fc-receptor-mediated interleukin 4 production by non-B, non-T cells.

1990 • 91 citations

Nippostrongylus brasiliensis: Mast cells and histamine levels in tissues of infected and normal rats

1979 • 76 citations

The antiviral activity of thiophosphate-substituted polyribonucleotides in vitro and in vivo

1970 • 56 citations

T help requirements for the generation of an in vivo IgE response: a late acting form of T cell help other than IL-4 is required for IgE but not for IgG1 production.

1989 • 52 citations

I<scp>G</scp>E AND I<scp>G</scp>GA ANTIBODY-MEDIATED RELEASE OF HISTAMINE FROM RAT PERITONEAL CELLS

1971 • 45 citations

Specific inhibition of lymphokine biosynthesis and autocrine growth using antisense oligonucleotides in Th1 and Th2 helper T cell clones.

1988 • 42 citations

Cytokines and lg switching: evolutionary divergence between mice and humans

1990 • 42 citations

The role of interleukin-4 in IgE and IgG subclass formation

1990 • 28 citations

Modulation of interleukin 1 beta gene expression using antisense phosphorothioate oligonucleotides.

1990 • 27 citations

Babesia microti and Babesia hylomysci: Spleen and phagocytosis in infected mice

1979 • 20 citations

Tumour necrosis factor, IL-1 and IL-6 in bronchoalveolar washings and theirin vitroproduction duringNippostrongylus brasiliensisinfection

1992 • 12 citations

Il-4 Production By T Depleted Cells From Nippostrongylus Brasiliensis Infected Mice

1989 • 5 citations

Evolutionary aspects structure and expression of the rat interleukin 4 gene

1990 • 2 citations