The oxidative desaturation of unsaturated fatty acids in animals

A NEW DEFICIENCY DISEASE PRODUCED BY THE RIGID EXCLUSION OF FAT FROM THE DIET

1929 • 1,140 citations

Effect of Saturated and Unsaturated Fatty Acids on the Desaturation in Vitro of Palmitic, Stearic, Oleic, Linoleic, and Linolenic Acids

1966 • 406 citations

A Function of Cytochrome b5 in Fatty Acid Desaturation by Rat Liver Microsomes

1971 • 389 citations

Biochemical Problems of Lipids

1964 • 354 citations

A MALONIC ACID DERIVATIVE AS AN INTERMEDIATE IN FATTY ACID SYNTHESIS

1958 • 338 citations

Electron-transfer mechanism associated with fatty acid desaturation catalyzed by liver microsomes

1966 • 285 citations

The desaturation step in the animal biosynthesis of polyunsaturated fatty acids

1971 • 228 citations

The intracellular localization of an enzymatic defect of lipid metabolism in diabetic rats

1964 • 216 citations

The dietary control of the microsomal stearyl CoA desaturation enzyme system in rat liver

1972 • 209 citations

Biosynthesis of saturated fatty acids.

1961 • 181 citations

Reconstitution of Hepatic Microsomal Stearoyl-Coenzyme A Desaturase System from Solubilized Components*

1972 • 173 citations

The preferred metabolic pathway from linoleic acid to arachidonic acid in vitro

1968 • 161 citations

A Requirement for Lipids by the Microsomal Stearyl Coenzyme A Desaturase

1969 • 158 citations

Regulation of unsaturated fatty acids biosynthesis 1. Effect of unsaturated fatty acid of 18 carbons on the microsomal desaturation of linoleic acid into γ-linolenic acid

1969 • 147 citations

Differential responses to fasting and subsequent feeding by microsomal systems of rat liver: 6- and 9-desaturation of fatty acids

1969 • 141 citations

Lipid-Protein Interactions in the Reconstitution of the Microsomal Reduced Nicotinamide Adenine Dinucleotide-Cytochrome b5 Reductase System

1973 • 128 citations

THE ROLE OF LONG-RANGE FORCES IN THE COHESION OF LIPOPROTEINS

1962 • 128 citations

Depression of microsomal desaturation of linoleictoy-linolenicacid in the alloxan-diabetic rat

1966 • 123 citations

Die enzymatische Dehydrierung der Stearinsäure zu Ölsäure

1959 • 120 citations

Chain Elongation of Linoleic Acid and Its Inhibition by Other Fatty Acids in Vitro

1967 • 115 citations

Requirement for Reduced Diphosphopyridine Nucleotide-Cytochrome b5 Reductase in Stearyl Coenzyme A Desaturation

1970 • 114 citations

Oxidative desaturation of eicosa-8,11-dienoic acid to eicosa-5,8,11-trienoic acid: comparison of different diets on oxidative desaturation at the 5,6 and 6,7 positions

1972 • 110 citations

Requirement for three protein components in microsomal stearyl coenzyme A desaturation

1971 • 96 citations

Protein Synthesis by Skeletal Muscle Ribosomes. Effect of Diabetes and Insulin^*

1967 • 93 citations

On the biosynthesis of dienoic fatty acid by animal tissues

1963 • 92 citations

Effect of arachidonic acid in the alloxan-diabetic rat

1968 • 92 citations

Mechanisms and stereochemistry in fatty acid metabolism

1970 • 90 citations

A Novel Mechanism for the Biosynthesis of Unsaturated Fatty Acids

1961 • 89 citations

Desaturation of Oleyl Phospholipid to Linoleyl Phospholipid in Torulopsis utilis

1973 • 80 citations

An in vitro and in vivo study of the conversion of eicosa-11, 14-dienoic acid to eicosa-5,11,14-trienoic acid and of the conversion of eicosa-11-enoic acid to eicosa-5,11-dienoic acid in the rat

1971 • 78 citations

Specificity of the fatty acid desaturases

1971 • 78 citations

Biosynthesis of polyenoic fatty acids

1961 • 75 citations

Fate of linoleic, arachidonic, and docosa-7,10,13,16-tetraenoic acids in rat testicles

1973 • 74 citations

Effect of diet on linoleic acid desaturation and on some enzymes of carbohydrate metabolism

1970 • 71 citations

Effect of insulin on the oxidative desaturation ofa‐linolenic, oleic and palmitic acids

1967 • 70 citations

Effect of Protein and Insulin on Linoleic Acid Desaturation of Normal and Diabetic Rats

1971 • 67 citations

Desaturation of saturated fatty acids by rat liver microsomes

1970 • 64 citations

Circadian rhythm of fatty acid desaturation in mouse liver

1973 • 63 citations

Conversion in vitro of linoleic acid into γ-linolenic acid by rat-liver enzymes

1962 • 63 citations

Metabolism of fatty acids of the linoleic acid series in testicles of diabetic rats

1970 • 57 citations

Studies on the Lipogenesis in Animal Tissues under Pathological Conditions

1961 • 54 citations

Kinetics of linoleic and arachidonic acid incorporation and eicosatrienoic depletion in the lipids of fat-deficient rats fed methyl linoleate and arachidonate

1965 • 51 citations

Assay and Isolation of a Cyanide-binding Protein of Rat Liver Microsomes

1970 • 49 citations

Chain Elongation of α- and γ-Linolenic Acids and the Effect of Other Fatty Acids on Their Conversion in Vitro

1968 • 48 citations

The biosynthesis of polyunsaturated fatty acids in plants

1971 • 46 citations

Competitive effect of alpha- and gamma-lionlenyl-CoA in linoleyl-CoA desaturation to gamma-linolenyl-CoA.

1969 • 44 citations

An in vitro studyof the effects of linoleic, eicosa-8,11,14-trienoic and arachidonic acids on the desaturation of stearic, oleic and eicosa-8,11-dienoic acid

1971 • 43 citations

Competitive effect of α- and γ-linolenyl-CoA and arachidonyl-CoA in linoleyl-CoA desaturation to γ-linolenyl-CoA

1969 • 41 citations

Effect of arachidonic acid on the microsomal desaturation of linoleic into γ-linolenic acid and their simultaneous incorporation into the phospholipids

1968 • 39 citations

Reciprocal interactions in the desaturation of linoleic acid into γ‐linolenic and eicosa‐8,11,14‐trienoic into arachidonic

1969 • 30 citations

Influence of Dietary Medium-Chain Fatty Acids on Rat Lipid Composition

1962 • 26 citations

The activating effect of dietary protein on linoleic acid desaturation

1972 • 25 citations

Effect of dietary glycerol on the [1−14C]stearic acid and [1−14C]linoleic acid desaturation of normal and diabetic rats

1973 • 23 citations

Comparative effect of a protein diet on the desaturation, elongation and simultaneous desaturation and elongation of linoleic acid

1972 • 20 citations

Regulation of polyunsaturated fatty acid biosynthesis in the rat.

1972 • 19 citations

Isoxazolidines, 1,3-amino alcohols and alcohols from long chain olefins

1971 • 11 citations

Interactions in the metabolism of polyunsaturated fatty acids: analysis by a simple mathematical model

1966 • 6 citations

Effect of ATP on the microsomal desaturation of unsaturated fatty acids

1971 • 4 citations