Acetone-inducible cytochrome P-450: Purification, catalytic activity, and interaction with cytochrome b5

Purification and characterization of liver microsomal cytochromes P-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or .beta.-naphthoflavone

1982 • 1,021 citations

Purification and characterization of a unique isozyme of cytochrome P-450 from liver microsomes of ethanol-treated rabbits.

1982 • 537 citations

N-Nitroso compounds: occurrence, biological effects and relevance to human cancer

1985 • 316 citations

Characterization of a major form of rat hepatic microsomal cytochrome P-450 induced by isoniazid.

1985 • 311 citations

Multiple forms of rat liver cytochrome P-450. Immunochemical evidence with antibody against cytochrome P-448.

1976 • 262 citations

The metabolism of acetone in rat.

1984 • 258 citations

Identification of ethanol-inducible P-450 isozyme 3a as the acetone and acetol monooxygenase of rabbit microsomes.

1985 • 256 citations

Drug Metabolism and Drug Toxicity

1985 • 249 citations

Catalytic activity of cytochrome P-450 isozyme 3a isolated from liver microsomes of ethanol-treated rabbits. Oxidation of alcohols.

1982 • 235 citations

Metabolism of nitrosamines by purified rabbit liver cytochrome P-450 isozymes.

1985 • 221 citations

Preparation of monospecific antibodies against two forms of rat liver cytochrome P-450 and quantitation of these antigens in microsomes

1979 • 180 citations

Liver microsomal expoxide hydrase. Solubilization, purification, and characterization.

1975 • 170 citations

High-affinity nitrosamine dealkylase system in rat liver microsomes and its induction by fasting.

1983 • 160 citations

Evidence that isoniazid and ethanol induce the same microsomal cytochrome P-450 in rat liver, an isozyme homologous to rabbit liver cytochrome P-450 isozyme 3a

1986 • 158 citations

Purification and characterization of two constitutive forms of rat liver microsomal cytochrome P-450.

1982 • 156 citations

Cytochrome P-450 isozyme 1 from phenobarbital-induced rat liver: purification, characterization, and interactions with metyrapone and cytochrome b5

1983 • 132 citations

The induction and competitive inhibition of a high affinity microsomal nitrosodimethylamine demethylase by ethanol

1982 • 127 citations

Chemical characterization of protein-protein interactions between cytochrome P-450 and cytochrome b5.

1985 • 104 citations

Dialkylnitrosamine bioactivation and carcinogenesis

1980 • 99 citations

Studies on the mechanisms of induction of N-nitrosodimethylamine demethylase by fasting, acetone, and ethanol

1984 • 93 citations

Hydroxylation of prostaglandins by inducible isozymes of rabbit liver microsomal cytochrome P-450. Participation of cytochrome b5.

1982 • 86 citations

Interaction of purified microsomal cytochrome P-450 with cytochrome b5

1981 • 85 citations

Immunochemical evidence for a role of cytochrome P-450 in liver microsomal ethanol oxidation

1984 • 84 citations

Isoniazid-induced Enflurane Defluorination in Humans

1982 • 84 citations

Induction of a high affinity nitrosamine demethylase in rat liver microsomes by acetone and isopropanol

1983 • 78 citations

Pyrazole-induced cytochrome P-450 in rat liver microsomes: An isozyme with high affinity for dimethylnitrosamine

1981 • 72 citations

Demethylation and denitrosation of nitrosamines by cytochrome P-450 isozymes

1985 • 71 citations

Alterations of microsomal monooxygenase system and carcinogen metabolism by streptozotocin-induced diabetes in rats

1983 • 69 citations

Immunochemical studies on the metabolism of nitrosamines by ethanol-inducible cytochrome P-450

1985 • 67 citations

Purification of liver microsomal cytochrome P-450 isozymes 3a and 6 from imidazole-treated rabbits. Evidence for the identity of isozyme 3a with the form obtained by ethanol treatment.

1984 • 65 citations

Potentiation of the hepatotoxicity of N-nitrosodimethylamine by fasting, diabetes, acetone, and isopropanol

1984 • 57 citations

Liver microsomal electron transport systems. III. The involvement of cytochrome b5 in the NADPH-supported cytochrome P-450-dependent hydroxylation of chlorobenzene

1974 • 56 citations

The nature of microsomal N-nitrosodimethylamine demethylase and its role in carcinogen activation

1985 • 53 citations

Effects of isoniazid treatment on selected hepatic mixed-function oxidases.

1979 • 49 citations

The identification of the heat-stable microsomal protein required for methoxyflurane metabolism as cytochrome b5.

1984 • 49 citations

Dimethylnitrosamine demethylation by reconstituted liver microsomal cytochrome P-450 enzyme system

1975 • 46 citations

The nature of nitrosamine denitrosation by rat liver microsomes

1982 • 46 citations

Enzyme specificity in the metabolic activation of N-nitrosodimethylamine to a mutagen for Chinese hamster V79 cells.

1985 • 43 citations

Amino acid induction and carbohydrate repression of dimethylnitrosamine demethylase in rat liver.

1970 • 43 citations

Monoclonal antibodies to ethanol induced cytochrome P-450 that inhibit aniline and nitrosamine metabolism

1986 • 40 citations

2-Propanol treatment induces selectively the metabolism of carbon tetrachloride to phosgene. Implications for carbon tetrachloride hepatotoxicity.

1981 • 27 citations

Induction of rabbit hepatic microsomal cytochrome P-450 by imidazole: Enhanced metabolic activity and altered substrate specificity

1984 • 25 citations