Molecular and Genetic Determinants of the Listeria monocytogenes Infectious Process

ABC Transporters: From Microorganisms to Man

1992 • 3,956 citations

Protein phosphorylation and regulation of adaptive responses in bacteria

1989 • 1,495 citations

Epidemic Listeriosis — Evidence for Transmission by Food

1983 • 1,492 citations

CELLULAR RESISTANCE TO INFECTION

1962 • 1,422 citations

Actin filaments and the growth, movement, and spread of the intracellular bacterial parasite, Listeria monocytogenes.

1989 • 1,268 citations

An Electron Microscopic Study

1987 • 1,144 citations

Immunity to Intracellular Bacteria

1993 • 1,085 citations

Role of hemolysin for the intracellular growth of Listeria monocytogenes.

1988 • 881 citations

Entry of L. monocytogenes into cells is mediated by internalin, a repeat protein reminiscent of surface antigens from gram-positive cocci

1991 • 823 citations

Environmental signals controlling expression of virulence determinants in bacteria

1992 • 803 citations

L. monocytogenes-induced actin assembly requires the actA gene product, a surface protein

1992 • 790 citations

Signal transduction schemes of bacteria

1993 • 781 citations

Listeria monocytogenes and listeric infections

1966 • 764 citations

Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin.

1989 • 724 citations

In vitro model of penetration and intracellular growth of Listeria monocytogenes in the human enterocyte-like cell line Caco-2

1987 • 714 citations

Protein phosphorylation and regulation of adaptive responses in bacteria.

1989 • 694 citations

Signal transduction in bacteria

1990 • 683 citations

A disease of rabbits characterised by a large mononuclear leucocytosis, caused by a hitherto undescribed bacillus Bacterium monocytogenes (n.sp.)

1926 • 667 citations

Molecular determinants of Listeria monocytogenes pathogenesis

1992 • 571 citations

The rate of actin-based motility of intracellular Listeria monocytogenes equals the rate of actin polymerization

1992 • 533 citations

Multiplication of Shigella flexneri within HeLa cells: lysis of the phagocytic vacuole and plasmid-mediated contact hemolysis

1986 • 509 citations

Bacterial toxins and cell membranes

1978 • 471 citations

Dual roles of plcA in Listeria monocytogenes pathogenesis

1993 • 452 citations

The Role of Cell-Mediated Immunity in Bacterial Infections

1981 • 452 citations

Transposon mutagenesis as a tool to study the role of hemolysin in the virulence of Listeria monocytogenes

1986 • 431 citations

Listeriolysin O is essential for virulence of Listeria monocytogenes: direct evidence obtained by gene complementation

1989 • 426 citations

Conservation of a hexapeptide sequence in the anchor region of surface proteins from Gram‐positive cocci

1990 • 412 citations

A novel bacterial virulence gene in Listeria monocytogenes required for host cell microfilament interaction with homology to the proline-rich region of vinculin.

1992 • 411 citations

Coordinate regulation of virulence genes in Listeria monocytogenes requires the product of the prfA gene

1992 • 404 citations

Nucleotide sequence of the lecithinase operon of Listeria monocytogenes and possible role of lecithinase in cell-to-cell spread

1992 • 393 citations

Listeria monocytogenes and listeric infections.

1966 • 387 citations

Purification, characterization, and toxicity of the sulfhydryl-activated hemolysin listeriolysin O from Listeria monocytogenes

1987 • 367 citations

Signal transduction in the mammalian cell during bacterial attachment and entry

1993 • 364 citations

Bacillus subtilis expressing a haemolysin gene from Listeria monocytogenes can grow in mammalian cells

1990 • 355 citations

Bacterial Protein Toxins: An Overview

2003 • 335 citations

Listeria monocytogenes moves rapidly through the host-cell cytoplasm by inducing directional actin assembly.

1990 • 321 citations

Bacterial proteins binding to the mammalian extracellular matrix

1993 • 318 citations

IpaB of Shigella flexneri causes entry into epithelial cells and escape from the phagocytic vacuole.

1992 • 316 citations

The Interaction of Bacteria with Mammalian Cells

1992 • 304 citations

Intracellular and cell-to-cell spread of Listeria monocytogenes involves interaction with F-actin in the enterocytelike cell line Caco-2

1990 • 301 citations

Motility as a factor in the colonisation of gnotobiotic piglets by Helicobacter pylori

1992 • 294 citations

Identification of a gene that positively regulates expression of listeriolysin, the major virulence factor of listeria monocytogenes.

1990 • 293 citations

Unipolar localization and ATPase activity of IcsA, a Shigella flexneri protein involved in intracellular movement

1993 • 293 citations

Molecular cloning and nucleotide sequencing of the gene for E. coli cAMP receptor protein

1982 • 283 citations

Involvement of profilin in the actin-based motility of L. monocytogenes in cells and in cell-free extracts

1994 • 282 citations

Identification of an extracellular protein of Listeria monocytogenes possibly involved in intracellular uptake by mammalian cells

1989 • 280 citations

Pleiotropic control of Listeria monocytogenes virulence factors by a gene that is autoregulated

1991 • 263 citations

Expression and phosphorylation of the Listeria monocytogenes ActA protein in mammalian cells.

1993 • 262 citations

Isolation of Listeria monocytogenes small-plaque mutants defective for intracellular growth and cell-to-cell spread

1990 • 254 citations

virG, a plasmid-coded virulence gene of Shigella flexneri: identification of the virG protein and determination of the complete coding sequence

1989 • 240 citations

Directional actin polymerization associated with spotted fever group Rickettsia infection of Vero cells

1993 • 237 citations

The expression of virulence genes in Listeria monocytogenes is thermoregulated

1992 • 236 citations

Exacerbation of murine listeriosis by a monoclonal antibody specific for the type 3 complement receptor of myelomonocytic cells. Absence of monocytes at infective foci allows Listeria to multiply in nonphagocytic cells.

1989 • 232 citations

The iap gene of Listeria monocytogenes is essential for cell viability, and its gene product, p60, has bacteriolytic activity

1993 • 226 citations

Regulation of the prfA transcriptional activator of Listeria monocytogenes: multiple promoter elements contribute to intracellular growth and cell-to-cell spread

1993 • 203 citations

Neutrophil-mediated dissolution of infected host cells as a defense strategy against a facultative intracellular bacterium.

1991 • 200 citations

Polarized distribution of Listeria monocytogenes surface protein ActA at the site of directional actin assembly

1993 • 196 citations

Identification of phosphatidylinositol‐specific phospholipase C activity in Listeria monocytogenes: a novel type of virulence factor?

1991 • 195 citations

Experimental Listeria enteritis. I. An electron microscopic study of the epithelial phase in experimental listeria infection.

1972 • 193 citations

Hemolysin supports survival but not entry of the intracellular bacterium Listeria monocytogenes

1988 • 192 citations

Attenuated mutants of the intracellular bacterium Listeria monocytogenes obtained by single amino acid substitutions in listeriolysin O

1990 • 191 citations

The ActA protein of Listeria monocytogenes acts as a nucleator inducing reorganization of the actin cytoskeleton.

1994 • 188 citations

Purification and characterization of an extracellular 29-kilodalton phospholipase C from Listeria monocytogenes

1991 • 184 citations

NtcA, a global nitrogen regulator from the cyanobacterium Synechococcus that belongs to the Crp family of bacterial regulators

1992 • 184 citations

icsB: a Shigella flexneri virulence gene necessary for the lysis of protrusions during intercellular spread

1992 • 178 citations

Cloning and sequence of the crp gene of Escherichia coli K 12

1982 • 178 citations

The gene coding for protein p60 of Listeria monocytogenes and its use as a specific probe for Listeria monocytogenes

1990 • 169 citations

Roles of motility and flagellar structure in pathogenicity of Vibrio cholerae: analysis of motility mutants in three animal models

1991 • 168 citations

Host cell actin assembly is necessary and likely to provide the propulsive force for intracellular movement of Listeria monocytogenes

1992 • 164 citations

Internalin‐mediated invasion of epithelial cells by Listeria monocytogenes is regulated by the bacterial growth state, temperature and the pleiotropic activator prfA

1993 • 161 citations

Detection of a gene encoding a phosphatidylinositol‐specific phospholipase C that is co‐ordinately expressed with listeriolysin in Listeria monocytogenes

1991 • 160 citations

Phylogenetic Analysis of the Genus Listeria Based on Reverse Transcriptase Sequencing of 16S rRNA

1991 • 155 citations

The virulence gene cluster of Listeria monocytogenes is also present in Listeria ivanovii, an animal pathogen, and Listeria seeligeri, a nonpathogenic species

1994 • 152 citations

Contribution of superoxide dismutase and catalase activities to Shigella flexneri pathogenesis

1990 • 148 citations

Intracellular movements of Rickettsia conorii adn R. typhi based on actin polymerization

1992 • 143 citations

Intracytoplasmic growth and virulence of Listeria monocytogenes auxotrophic mutants

1993 • 142 citations

Five Listeria monocytogenes genes preferentially expressed in infected mammalian cells: plcA, purH, purD, pyrE and an arginine ABC transporter gene, arpJ

1994 • 140 citations

Cell-mediated immunity to intestinal infection

1980 • 139 citations

Intact motility as a Salmonella typhi invasion-related factor

1988 • 136 citations

Molecular cloning, sequencing, and identification of a metalloprotease gene from Listeria monocytogenes that is species specific and physically linked to the listeriolysin gene

1991 • 132 citations

RICKETTSIA SPECIES (AS ORGANISMS)

1990 • 130 citations

Structural and functional properties of the p60 proteins from different Listeria species

1992 • 130 citations

Capacity of listeriolysin O, streptolysin O, and perfringolysin O to mediate growth of Bacillus subtilis within mammalian cells

1992 • 127 citations

Detection of listeriolysin, the thiol-dependent hemolysin in Listeria monocytogenes, Listeria ivanovii, and Listeria seeligeri

1989 • 123 citations

Identification of a new operon involved in Listeria monocytogenes virulence: its first gene encodes a protein homologous to bacterial metalloproteases

1991 • 122 citations

Listeria monocytogenes. A model system for the molecular study of intracellular parasitism.

1989 • 121 citations

Expression of listeriolysin and phosphatidylinositol‐specific phospholipase C is repressed by the plant‐derived molecule cellobiose in Listeria monocytogenes

1993 • 120 citations

Thiol-activated (oxygen-labile) cytolysins

1978 • 119 citations

Transcriptional mapping and nucleotide sequence of the Listeria monocytogenes hlyA region reveal structural features that may be involved in regulation

1989 • 111 citations

Reduced virulence of a Listeria monocytogenes phospholipase-deficient mutant obtained by transposon insertion into the zinc metalloprotease gene

1992 • 107 citations

A Chromosomal Locus Which Controls the Ability of Shigella flexneri to Evoke Keratoconjunctivitis

1971 • 105 citations

Roles of complement and complement receptor type 3 in phagocytosis of Listeria monocytogenes by inflammatory mouse peritoneal macrophages

1991 • 104 citations

Surface‐associated, PrfA‐regulated proteins of Listeria monocytogenes synthesized under stress conditions

1993 • 104 citations

Penetration of host cells by Rickettsia rickettsii appears to be mediated by a phospholipase of rickettsial origin

1992 • 100 citations

The virulence regulator protein of Listeria ivanovii is highly homologous to PrfA from Listeria monocytogenes and both belong to the Crp‐Fnr family of transcription regulators

1994 • 99 citations

Monoclonal antibodies demonstrate that superoxide dismutase contributes to protection of Nocardia asteroides within the intact host

1990 • 98 citations

Dual promoters of the Listeria monocytogenes prfA transcriptional activator appear essential in vitro but are redundant in vivo

1994 • 91 citations

Production of Thiol-dependent Haemolysins by Listeria monocytogenes and Related Species

1989 • 91 citations

Cloning and characterization of a gene encoding flagellin of Listeria monocytogenes

1992 • 90 citations

Innate immunity to a facultative intracellular bacterial pathogen

1992 • 89 citations

Transcriptional regulation of prfA and PrfA‐regulated virulence genes in Listeria monocytogenes

1994 • 89 citations

Synthesis and secretion of interferon by murine fibroblasts in response to intracellular Listeria monocytogenes

1986 • 88 citations

The wily ways of a parasite: induction of actin assembly by Listeria

1993 • 87 citations

Development of an auxotrophic oral live Shigella flexneri vaccine

1988 • 86 citations

Nonspecific phospholipase C of Listeria monocytogenes: activity on phospholipids in Triton X-100-mixed micelles and in biological membranes

1993 • 86 citations

A microbiological, histopathological and immunohistological study of the intragastric inoculation of Listeria monocytogenes in mice

1992 • 85 citations

The zinc metalloprotease of Listeria monocytogenes is required for maturation of phosphatidylcholine phospholipase C: direct evidence obtained by gene complementation

1993 • 83 citations

Purification and characterization of Listeria monocytogenes phosphatidylinositol-specific phospholipase C

1992 • 82 citations

G- to F-actin modulation by a single amino acid substitution in the actin binding site of actobindin and thymosin beta 4.

1992 • 77 citations

Induction of protective CD8⁺ T lymphocytes by an attenuated Listeria monocytogenes actA mutant

1992 • 73 citations

Synthesis of species-specific stress proteins by virulent strains of Listeria monocytogenes

1990 • 70 citations

The nucleation-release model of actin filament dynamics in cell motility

1992 • 69 citations

Transcriptional activation of the Listeria monocytogenes hemolysin gene in Bacillus subtilis

1992 • 66 citations

The actin‐based motility of the facultative intracellular pathogen Listeria monocytogenes

1994 • 66 citations

Synthesis of listeriolysin in Listeria monocytogenes under heat shock conditions

1989 • 66 citations

A nonvirulent mutant of Listeria monocytogenes does not move intracellularly but still induces polymerization of actin

1990 • 66 citations

Listeria ivanovii is capable of cell-to-cell spread involving actin polymerization

1993 • 65 citations

Levels of Listeria monocytogenes hemolysin are not directly proportional to virulence in experimental infections of mice

1988 • 62 citations

Expression of the iap gene coding for protein p60 of Listeria monocytogenes is controlled on the posttranscriptional level

1991 • 62 citations

Physical map of the Listeria monocytogenes chromosome

1992 • 59 citations

Listericidal and nonlistericidal mouse macrophages differ in complement receptor type 3-mediated phagocytosis of L. monocytogenes and in preventing escape of the bacteria into the cytoplasm

1992 • 59 citations

Listeriolysin genes: complete sequence of ilo from Listeria ivanovii and of lso from Listeria seeligeri

1992 • 57 citations

Arrest of Listeria movement in host cells by a bacterial ActA analogue: implications for actin-based motility.

1994 • 54 citations

Cell-Surface Location of Listeria-Specific Protein p60 - Detection of Listeria Cells by Indirect Immunofluorescence

1993 • 53 citations

Recent developments in the study of virulence in Listeria monocytogenes.

1988 • 53 citations

Phosphorylation of IcsA by cAMP‐dependent protein kinase and its effect on intercellular spread of Shigella flexneri

1992 • 49 citations

Electron microscopic studies in experimental keratoconjunctivitis listeriosa. I. Penetration of Listeria monocytogenes into corneal epithelial cells.

1970 • 49 citations

Nonhemolytic Listeria monocytogenes mutants that are also noninvasive for mammalian cells in culture: evidence for coordinate regulation of virulence

1990 • 48 citations

Cloning, characterization, and expression in Escherichia coli of a gene encoding Listeria seeligeri catalase, a bacterial enzyme highly homologous to mammalian catalases

1991 • 44 citations

Mutations affecting hemolysin production inListeria monocytogeneslocated outside the listeriolysin gene

1989 • 43 citations

Degenerate PCR primers for the amplification of fragments from genes encoding response regulators from a range of pathogenic bacteria

1992 • 43 citations

Degenerate PCR primers for the amplification of fragments from genes encoding response regulators from a range of pathogenic bacteria

1992 • 40 citations

Pathogenesis of Shigellosis

1993 • 37 citations

A gene encoding a Superoxide dismutase of the facultative intracellular bacterium Listeria monocytogenes

1992 • 36 citations

Loss of catalase activity in Tn1545-induced mutants does not reduce growth of Listeria monocytogenes in vivo

1989 • 36 citations

POSITIVE REGULATION IN THE GRAM-POSITIVE BACTERIUM: Bacillus subtilis

1992 • 30 citations

Lactobacilluscasei contains a member of the CRP-FNR family

1993 • 30 citations

Production of Opacity in Egg-Yolk Medium by Listeria monocytogenes

1962 • 27 citations

Sequences homologous to the listeriolysin O gene region of Listeria monocytogenes are present in virulent and avirulent haemolytic species of the genus Listeria

1989 • 23 citations

Experimental listeria cystitis

1973 • 17 citations

Further characterization of Listeria monocytogenes serotype 5

1978 • 11 citations

Sequences homologous to the listeriolysin O gene region of Listeria monocytogenes are present in virulent and avirulent haemolytic species of the genus Listeria

1989 • 10 citations

Pathogenesis of Shigellosis

1992 • 5 citations