Topiramate in the New Generation of Drugs: Efficacy in the Treatment of Alcoholic Patients

Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment

1978 • 2,231 citations

Assessment of Alcohol Withdrawal: the revised clinical institute withdrawal assessment for alcohol scale (CIWA‐Ar)

1989 • 1,830 citations

An Overview of the Preclinical Aspects of Topiramate: Pharmacology, Pharmacokinetics, and Mechanism of Action

2000 • 802 citations

Oral topiramate for treatment of alcohol dependence: a randomised controlled trial

2003 • 741 citations

Alcoholism: Allostasis and Beyond

2003 • 738 citations

The Obsessive Compulsive Drinking Scale: A Self‐Rated Instrument for the Quantification of Thoughts about Alcohol and Drinking Behavior

1995 • 646 citations

Topiramate for Treating Alcohol Dependence<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

2007 • 531 citations

Alcoholism: a controlled trial of "treatment" and "advice".

1977 • 496 citations

Topiramate in the Treatment of Binge Eating Disorder Associated With Obesity: A Randomized, Placebo-Controlled Trial

2003 • 468 citations

The Role of Glutamatergic Neurotransmission in the Pathophysiology of Alcoholism

1998 • 390 citations

Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold

1997 • 359 citations

Cellular Actions of Topiramate: Blockade of Kainate‐Evoked Inward Currents in Cultured Hippocampal Neurons

2000 • 349 citations

A 6-Month Randomized, Placebo-Controlled, Dose-Ranging Trial of Topiramate for Weight Loss in Obesity

2003 • 342 citations

Activation of locus coeruleus from nucleus paragigantocellularis: a new excitatory amino acid pathway in brain

1988 • 342 citations

Topiramate as an Inhibitor of Carbonic Anhydrase Isoenzymes

2000 • 311 citations

CDT, GGT, and AST As Markers of Alcohol Use: The WHO/ISBRA Collaborative Project

2002 • 282 citations

Elevated levels of GluR1 in the midbrain: a trigger for sensitization to drugs of abuse?

2002 • 279 citations

Clinical management--imipramine/placebo administration manual. NIMH Treatment of Depression Collaborative Research Program.

1987 • 278 citations

Topiramate-associated acute, bilateral, secondary angle-closure glaucoma

2004 • 275 citations

Modulation of High‐Voltage–Activated Calcium Channels in Dentate Granule Cells by Topiramate

2000 • 271 citations

Topiramate Modulates GABA‐Evoked Currents in Murine Cortical Neurons by a Nonbenzodiazepine Mechanism

2000 • 270 citations

Update on neuropharmacological treatments for alcoholism: Scientific basis and clinical findings

2007 • 264 citations

A potent excitatory input to the nucleus locus coeruleus from the ventrolateral medulla

1986 • 235 citations

Efficacy and Tolerability of the New Antiepileptic Drugs, II: Treatment of Refractory Epilepsy: Report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society

2004 • 216 citations

Selective Antagonism of GluR5 Kainate-Receptor-Mediated Synaptic Currents by Topiramate in Rat Basolateral Amygdala Neurons

2003 • 212 citations

Effect of Topiramate on the Pharmacokinetics of an Oral Contraceptive Containing Norethindrone and Ethinyl Estradiol in Patients with Epilepsy

1997 • 208 citations

The New Generation of GABA Enhancers

2001 • 208 citations

Opiate state controls bi-directional reward signaling via GABAA receptors in the ventral tegmental area

2004 • 201 citations

Inhibition of transient and persistent Na+ current fractions by the new anticonvulsant topiramate.

1999 • 179 citations

Progress report on new antiepileptic drugs: a summary of the fourth Eilat conference (EILAT IV)

1999 • 178 citations

Two new actions of topiramate: inhibition of depolarizing GABAA-mediated responses and activation of a potassium conductance

2002 • 175 citations

The Clinical Pharmacokinetics of the Newer Antiepileptic Drugs

1996 • 171 citations

Topiramate Blocks Kainate‐Evoked Cobalt Influx into Cultured Neurons

2000 • 169 citations

Steady‐State Pharmacokinetics of Topiramate and Carbamazepine in Patients with Epilepsy During Monotherapy and Concomitant Therapy

1996 • 153 citations

Effect of Topiramate or Carbamazepine on the Pharmacokinetics of an Oral Contraceptive Containing Norethindrone and Ethinyl Estradiol in Healthy Obese and Nonobese Female Subjects

2003 • 152 citations

Oral Topiramate Reduces the Consequences of Drinking and Improves theQuality of Life of Alcohol-Dependent Individuals

2004 • 147 citations

Clinical Pharmacology of Topiramate: A Review

2000 • 141 citations

Comparing topiramate with naltrexone in the treatment of alcohol dependence*

2008 • 140 citations

Topiramate blocks perinatal hypoxia‐induced seizures in rat pups

2001 • 138 citations

Recent Advances in the Development of Treatments for Alcohol and Cocaine Dependence

2005 • 130 citations

Comparison of the Steady‐State Pharmacokinetics of Topiramate and Valproate in Patients with Epilepsy During Monotherapy and Concomitant Therapy

1997 • 116 citations

Improvement of Physical Health and Quality of Life of Alcohol-Dependent Individuals With Topiramate Treatment<subtitle>US Multisite Randomized Controlled Trial</subtitle>

2008 • 115 citations

Topiramate reduces neuronal injury after experimental status epilepticus

1999 • 113 citations

Effects of Topiramate on Urge to Drink and the Subjective Effects of Alcohol: A Preliminary Laboratory Study

2008 • 110 citations

Tonic regulation of the activity of noradrenergic neurons in the locus coeruleus of the conscious rat studied by dual-probe microdialysis

1999 • 109 citations

Topiramate Titration and Tolerability

2001 • 98 citations

Long-term effects of topiramate on bipolar mood instability, weight change and glycemic control: a case-series

2001 • 86 citations

An open randomized trial comparing disulfiram and topiramate in the treatment of alcohol dependence

2007 • 86 citations

Topiramate as a neuroprotectant in a rat model of global ischemia-induced neurodegeneration

2001 • 83 citations

Modulation of Impulsivity by Topiramate

2009 • 80 citations

Psychometric Properties and Validity of the Obsessive‐Compulsive Drinking Scale

1996 • 79 citations

Progress in the Development of Topiramate for Treating Alcohol Dependence: From a Hypothesis to a Proof‐of‐Concept Study

2004 • 77 citations

Topiramate-Induced Nephrolithiasis

2002 • 76 citations

Topiramate and Phenytoin Pharmacokinetics During Repetitive Monotherapy and Combination Therapy to Epileptic Patients

2002 • 75 citations

A preliminary pharmacogenetic investigation of adverse events from topiramate in heavy drinkers.

2009 • 69 citations

Topiramate selectively attenuates nicotine‐induced increases in monoamine release

2001 • 68 citations

Effects of Topiramate in the Treatment of Alcohol Dependence

2004 • 67 citations

Oligohydrosis and Hyperthermia: Pilot Study of a Novel Topiramate Adverse Effect

2003 • 66 citations

Using Topiramate or Naltrexone for the Treatment of Alcohol‐Dependent Patients

2008 • 66 citations

Mechanism of action of newer anticonvulsants.

2003 • 60 citations

Topiramate in the Long‐Term Management of Refractory Epilepsy

2000 • 60 citations

Topiramate and Lamotrigine Pharmacokinetics during Repetitive Monotherapy and Combination Therapy in Epilepsy Patients

2003 • 56 citations

Topiramate for Migraine Prevention

2006 • 56 citations

Topiramate attenuates withdrawal signs after chronic intermittent ethanol in rats

2003 • 55 citations

Nonfocal Generalized Tonic–Clonic Seizures: Response During Long‐Term Topiramate Treatment

2000 • 53 citations

Topiramate alters excitatory synaptic transmission in mouse hippocampus

2003 • 52 citations

Topiramate reduces ethanol consumption by C57BL/6 mice

2006 • 50 citations

Anticonvulsants – Antidepressants Pharmacokinetic Drug Interactions: The Role of the CYP450 System in Psychopharmacology

2008 • 49 citations

Topiramate (Topamax) reduces conditioned abstinence behaviours and handling-induced convulsions (HIC) after chronic administration of alcohol in Swiss-Webster MICE

2007 • 45 citations

Topiramate in Combat-Related Posttraumatic Stress Disorder

2009 • 44 citations

Alcohol withdrawal reaction as a result of adaptive changes of excitatory amino acid receptors

1992 • 43 citations

Effects of Topiramate on Ethanol and Saccharin Consumption and Preferences in C57BL/6J Mice

2005 • 43 citations

Elevated Intraocular Pressure and Myopic Shift Linked to Topiramate Use

2007 • 42 citations

Topiramate protects against glutamate- and kainate-induced neurotoxicity in primary neuronal–astroglial cultures

2003 • 42 citations

Effect of topiramate treatment on ethanol consumption in rats

2009 • 40 citations

Acute myopia and angle closure caused by topiramate, a drug used for prophylaxis of migraine

2006 • 40 citations

A pilot study of Topiramate (Topamax) in the treatment of tonic-clonic seizures of alcohol withdrawal syndromes.

2002 • 39 citations

Topiramate reduces the harm of excessive drinking: implications for public health and primary care

2006 • 36 citations

Nicotine-induced excitation of locus coeruleus neurons is blocked by elevated levels of endogenous kynurenic acid

2000 • 33 citations

Topiramate Titration to Response: Analysis of Individualized Therapy Study (TRAITS)

2003 • 31 citations

Topiramate attenuates the stress-induced increase in alcohol consumption and preference in male C57BL/6J mice

2008 • 23 citations

Effects of Topiramate on Kainate‐ and Domoate‐Activated [¹⁴C]Guanidinium Ion Flux Through GluR6 Channels in Transfected BHK Cells Using Cytostar‐T Scintillating Microplates

2000 • 23 citations

The selective iGluR1-4 (AMPA) antagonist LY300168 attenuates morphine-withdrawal-induced activation of locus coeruleus neurons and behavioural signs of morphine withdrawal

2003 • 19 citations

Challenges and Opportunities for Medications Development in Alcoholism: An International Perspective on Collaborations Between Academia and Industry

2005 • 19 citations

Argon Laser Peripheral Iridoplasty for Topiramate-induced Bilateral Acute Angle Closure

2009 • 18 citations

Topiramate induced acute transient myopia: a case report

2009 • 14 citations

Newer GABAergic agents for pharmacotherapy of infantile spasms

2002 • 14 citations

Antiischemic effects of topiramate in a transient global forebrain ischemia model: a neurochemical, histological, and behavioral evaluation.

2003 • 13 citations

Bilateral acute onset myopia and angle closure glaucoma after oral topiramate: a case report.

2008 • 12 citations

New Therapies for Alcohol Dependence Open Options for Office-Based Treatment

2007 • 3 citations