Inhibition of transient and persistent Na+ current fractions by the new anticonvulsant topiramate.

Persistent Sodium Current in Mammalian Central Neurons

1996 • 640 citations

Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels.

1996 • 488 citations

Cellular Mechanisms of Epilepsy: A Status Report

1987 • 434 citations

Properties of persistent sodium conductance and calcium conductance of layer V neurons from cat sensorimotor cortex in vitro

1985 • 430 citations

Synchronized excitation and inhibition driven by intrinsically bursting neurons in neocortex

1989 • 420 citations

A voltage-dependent persistent sodium current in mammalian hippocampal neurons.

1990 • 377 citations

Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold

1997 • 359 citations

Topiramate: Preclinical Evaluation of a Structurally Novel Anticonvulsant

1994 • 348 citations

Modal gating of Na+ channels as a mechanism of persistent Na+ current in pyramidal neurons from rat and cat sensorimotor cortex

1993 • 303 citations

Na+ channels must deactivate to recover from inactivation

1994 • 303 citations

An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels

1992 • 281 citations

Sodium valproate, but not ethosuximide, produces use- and voltage-dependent limitation of high frequency repetitive firing of action potentials of mouse central neurons in cell culture.

1986 • 272 citations

Phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed adult epilepsy: a randomised comparative monotherapy trial.

1995 • 257 citations

Interaction of the antiepileptic drug lamotrigine with recombinant rat brain type IIA Na+ channels and with native Na+ channels in rat hippocampal neurones

1995 • 255 citations

Voltage clamp analysis of the inhibitory actions of diphenylhydantoin and carbamazepine on voltage-sensitive sodium channels in neuroblastoma cells.

1985 • 225 citations

Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule cells

1997 • 220 citations

Slow binding of phenytoin to inactivated sodium channels in rat hippocampal neurons.

1994 • 201 citations

A PHARMACOLOGICAL AND CLINICAL REVIEW ON TOPIRAMATE, A NEW ANTIEPILEPTIC DRUG

1997 • 169 citations

Carbamazepine Inhibition of Neuronal Na⁺ Currents: Quantitative Distinction from Phenytoin and Possible Therapeutic Implications

1997 • 163 citations

Topiramate Monotherapy for Partial Onset Seizures

1997 • 159 citations

Characterization of lamotrigine inhibition of Na⁺ channels in rat hippocampal neurones

1997 • 148 citations

Kinetics of slow inactivation of persistent sodium current in layer V neurons of mouse neocortical slices

1996 • 134 citations

Characterization of the block of sodium channels by phenytoin in mouse neuroblastoma cells.

1984 • 133 citations

Late Sodium Channel Openings Underlying Epileptiform Activity Are Preferentially Diminished by the Anticonvulsant Phenytoin

1997 • 130 citations

Stepwise repolarization from Ca2+ plateaus in neocortical pyramidal cells: evidence for nonhomogeneous distribution of HVA Ca2+ channels in dendrites

1993 • 125 citations

Heterogeneity of rat corticospinal neurons

1993 • 112 citations

Ionic mechanisms underlying burst firing in pyramidal neurons: intracellular study in rat sensorimotor cortex

1995 • 106 citations

Anemone toxin (ATX II)‐induced increase in persistent sodium current: effects on the firing properties of rat neocortical pyramidal neurones

1998 • 104 citations

Effects of phenytoin on the persistent Na+ current of mammalian CNS neurones

1995 • 88 citations

Different voltage dependence of transient and persistent Na+ currents is compatible with modal-gating hypothesis for sodium channels

1994 • 80 citations

Pharmacokinetics and Interaction Profile of Topiramate: Review and Comparison with Other Newer Antiepileptic Drugs

1997 • 77 citations

Postnatal differentiation of firing properties and morphological characteristics in layer V pyramidal neurons of the sensorimotor cortex

1998 • 73 citations

Steady-state availability of sodium channels. Interactions between activation and slow inactivation

1992 • 69 citations

Slow depolarizing afterpotentials in neocortical neurons are sodium and calcium dependent

1992 • 63 citations

Endogenous bursts underlie seizurelike activity in solitary excitatory hippocampal neurons in microcultures

1994 • 55 citations

Long-Term Experience with Topiramate as Adjunctive Therapy and as Monotherapy in Patients with Partial Onset Seizures: Retrospective Survey of Open-Label Treatment

1997 • 52 citations

A novel voltage‐dependent cation current in rat neocortical neurones.

1994 • 52 citations

A TTX-sensitive conductance underlying burst firing in isolated pyramidal neurons from rat neocortex

1996 • 32 citations

A phenytoin‐sensitive cationic current participates in generating the afterdepolarization and burst afterdischarge in rat neocortical pyramidal cells

1998 • 28 citations