Two new actions of topiramate: inhibition of depolarizing GABAA-mediated responses and activation of a potassium conductance

An Overview of the Preclinical Aspects of Topiramate: Pharmacology, Pharmacokinetics, and Mechanism of Action

2000 • 802 citations

Ionic Mechanisms of Neuronal Excitation by Inhibitory GABA _A Receptors

1995 • 800 citations

Paired‐pulse depression of monosynaptic GABA‐mediated inhibitory postsynaptic responses in rat hippocampus.

1990 • 709 citations

Ionic basis of GABAA receptor channel function in the nervous system

1994 • 679 citations

TASK, a human background K+ channel to sense external pH variations near physiological pH

1997 • 619 citations

GABAB-receptor-activated K+ current in voltage-clamped CA3 pyramidal cells in hippocampal cultures.

1985 • 468 citations

Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold

1997 • 359 citations

Cellular Actions of Topiramate: Blockade of Kainate‐Evoked Inward Currents in Cultured Hippocampal Neurons

2000 • 349 citations

Topiramate: Preclinical Evaluation of a Structurally Novel Anticonvulsant

1994 • 348 citations

Long-Lasting GABA-Mediated Depolarization Evoked by High-Frequency Stimulation in Pyramidal Neurons of Rat Hippocampal Slice Is Attributable to a Network-Driven, Bicarbonate-Dependent K⁺Transient

1997 • 339 citations

Structure-activity relations of the cardiac gap junction channel

1990 • 312 citations

Topiramate as an Inhibitor of Carbonic Anhydrase Isoenzymes

2000 • 311 citations

Modulation of High‐Voltage–Activated Calcium Channels in Dentate Granule Cells by Topiramate

2000 • 271 citations

Topiramate Modulates GABA‐Evoked Currents in Murine Cortical Neurons by a Nonbenzodiazepine Mechanism

2000 • 270 citations

Voltage-Dependent Proton Transport by the Voltage Sensor of the Shaker K+ Channel

1997 • 224 citations

Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule cells

1997 • 220 citations

Sodium channels as molecular targets for antiepileptic drugs

1998 • 214 citations

Effects of extracellular pH on voltage‐gated Na+, K+ and Ca2+ currents in isolated rat CA1 neurons.

1996 • 213 citations

Ictal Epileptiform Activity Is Facilitated by Hippocampal GABA_A Receptor-Mediated Oscillations

2000 • 181 citations

Inhibition of transient and persistent Na+ current fractions by the new anticonvulsant topiramate.

1999 • 179 citations

KCNQ2/KCNQ3 K+ channels and the molecular pathogenesis of epilepsy: implications for therapy

2000 • 144 citations

Participation of GABA_A-Mediated Inhibition in Ictallike Discharges in the Rat Entorhinal Cortex

1998 • 136 citations

CGP 55845A: A potent antagonist of GABAb receptors in the CA1 region of rat hippocampus

1993 • 113 citations

Role of HCO3- ions in depolarizing GABAA receptor-mediated responses in pyramidal cells of rat hippocampus

1993 • 112 citations

Synchronization of GABAergic interneuronal networks during seizure‐like activity in the rat horizontal hippocampal slice

1999 • 109 citations

Modulation of extracellular pH by glutamate and GABA in rat hippocampal slices

1992 • 101 citations

Intracellular carbonic anhydrase activity and its role in GABA‐induced acidosis in isolated rat hippocampal pyramidal neurones

1993 • 90 citations

Proton Modulation of Functionally Distinct GABA A Receptors in Acutely Isolated Pyramidal Neurons of Rat Hippocampus

1996 • 87 citations

Interstitial PCO2 and pH in rat hippocampal slices measured by means of a novel fast CO2/H+-sensitive microelectrode based on a PVC-gelled membrane

1993 • 84 citations

Effects of intra‐ and extracellular acidifications on single channel Kir2.3 currents

1999 • 74 citations

Topiramate in the Long‐Term Management of Refractory Epilepsy

2000 • 60 citations

High Intracellular Cl⁻Concentrations Depress G-Protein-Modulated Ionic Conductances

1997 • 55 citations

Nonfocal Generalized Tonic–Clonic Seizures: Response During Long‐Term Topiramate Treatment

2000 • 53 citations

Interstitial Carbonic Anhydrase (CA) Activity in Brain Is Attributable to Membrane-Bound CA Type IV

2000 • 52 citations

A comparison of topiramate and acetazolamide on seizure duration and paired-pulse inhibition in the dentate gyrus of the rat

2000 • 44 citations

Frequency‐dependent inhibition of neuronal activity by topiramate in rat hippocampal slices

1998 • 40 citations

Activation of GABAergic function necessary for afterdischarge generation in rat hippocampal slices

1996 • 39 citations

Comparison of immunocytochemical staining of astrocytes, oligodendrocytes, and myelinated fibers in the brains of carbonic anhydrase II-deficient mice and normal littermates

1991 • 33 citations

Cl⁻ Accumulation Does Not Account for the Depolarizing Phase of the Synaptic GABA Response in Hippocampal Pyramidal Cells

1999 • 30 citations

Mechanisms of Tolerance to the Anticonvulsant Effects of Acetazolamide in Mice: Relation to the Activity and Amount of Carbonic Anhydrase in Brain

1989 • 30 citations

Multiple actions of the novel anticonvulsant drug topiramate in the rat subiculum in vitro

1998 • 28 citations

Neuroactive steroids induce GABA_A receptor‐mediated depolarizing postsynaptic potentials in hippocampal CA1 pyramidal cells of the rat

1998 • 25 citations