The Role of Glutamatergic Neurotransmission in the Pathophysiology of Alcoholism

Cloned Glutamate Receptors

1994 • 3,989 citations

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders

1994 • 2,668 citations

Ethanol Inhibits NMDA-Activated Ion Current in Hippocampal Neurons

1989 • 1,456 citations

Physiological and pathophysiological roles of excitatory amino acids during central nervous system development

1990 • 1,427 citations

Structure and function of the NMDA receptor channel

1995 • 645 citations

Drug addiction: A model for the molecular basis of neural plasticity

1993 • 548 citations

FETAL ALCOHOL SYNDROME

1998 • 496 citations

Relapse Prevention by Acamprosate

1996 • 488 citations

Ethanol withdrawal seizures and the NMDA receptor complex

1990 • 444 citations

NMDA Receptor Heterogeneity During Postnatal Development of the Rat Brain: Differential Expression of the NR2A, NR2B, and NR2C Subunit Proteins

1997 • 439 citations

Ethanol Specifically Potentiates GABA-Mediated Neurotransmission in Feline Cerebral Cortex

1980 • 322 citations

Anti-craving compounds for ethanol: new pharmacological tools to study addictive processes

1997 • 298 citations

Neurotransmitter and neuromodulatory mechanisms involved in alcohol abuse and alcoholism

1995 • 269 citations

Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal

1991 • 269 citations

Ethanol withdrawal is associated with increased extracellular glutamate in the rat striatum

1995 • 243 citations

Rapid Communication Chronic Ingestion of Ethanol Up‐Regulates NMDAR1 Receptor Subunit Immunoreactivity in Rat Hippocampus

1994 • 235 citations

Ethanol potentiates and blocks NMDA‐activated single‐channel currents in rat hippocampal pyramidal cells

1989 • 204 citations

Effects of ethanol on neurotransmitter release by rat brain cortical.

1975 • 199 citations

Acamprosate (calciumacetylhomotaurinate) decreases postsynaptic potentials in the rat neocortex: possible involvement of excitatory amino acid receptors

1993 • 178 citations

Differential ethanol sensitivity of recombinant N-methyl-D-aspartate receptor subunits.

1994 • 171 citations

Ethanol Inhibition of N‐Methyl‐D‐Aspartate‐Stimulated Endogenous Dopamine Release from Rat Striatal Slices: Reversal by Glycine

1990 • 162 citations

Protective effects of the glutamate antagonist MK-801 on pyrithiamine- induced lesions and amino acid changes in rat brain

1990 • 154 citations

Radioligand binding to the N-methyl-d-aspartate receptor/ionophore complex: alterations by ethanol in vitro and by chronic in vivo ethanol ingestion

1993 • 154 citations

Ethanol Promotes Apoptosis in Cerebellar Granule Cells by Inhibiting the Trophic Effect of NMDA

1997 • 147 citations

Ethanol inhibits NMDA-evoked electrophysiological activity in vivo.

1991 • 141 citations

Glycine site-directed agonists reverse the actions of ethanol at the N-methyl-D-aspartate receptor.

1990 • 136 citations

Pharmacological treatment of alcohol intoxication, withdrawal and dependence: a critical review.

1987 • 135 citations

Inhibition of NMDA-evoked electrophysiological activity by ethanol in selected brain regions: evidence for ethanol-sensitive and ethanol-insensitive NMDA-evoked responses

1993 • 128 citations

Prenatal ethanol exposure decreases hippocampal NMDA-sensitive [3H]-Glutamate binding site density in 45-day-old rats

1991 • 117 citations

Pharmacotherapies for Alcoholism: Promising Agents and Clinical Issues

1991 • 112 citations

Prenatal ethanol exposure during the last third of gestation in rat reduces hippocampal NMDA agonist binding site density in 45-day-old offspring

1992 • 109 citations

Extracellular Glutamate Is Increased in Thalamus During Thiamine Deficiency‐Induced Lesions and Is Blocked by MK‐801

1993 • 105 citations

Long-term potentiation and N-methyl-d-aspartate receptors: Foundations of memory and neurologic disease?

1995 • 97 citations

Ethanol inhibits glutamate-induced currents in heteromeric NMDA receptor subtypes

1993 • 96 citations

The role of the NMDA receptor in ethanol withdrawal

1994 • 94 citations

Glutamate Receptors in the Frontal Cortex of Alcoholics

1996 • 89 citations

Effects of dizocilpine (MK-801) and ethanol on the eeg and event-related potentials (erps) in rats

1992 • 86 citations

Comparison of the effects of the uncompetitive N-methyl-D-aspartate antagonist (+-)-5-aminocarbonyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imine (ADCI) with its structural analogs dizocilpine (MK-801) and carbamazepine on ethanol withdrawal seizures.

1992 • 85 citations

Prenatal ethanol exposure decreases hippocampal 3H-glutamate binding in 45-day-old rats

1988 • 85 citations

Glutamate receptors in alcohol withdrawal-induced neurotoxicity

1995 • 83 citations

Ethanol inhibition of N-methyl-d-aspartate-activated ion current in rat hippocampal neurons is not competitive with glycine

1992 • 82 citations

High ethanol sensitivity of recombinant AMPA-type glutamate receptors expressed in mammalian cells

1993 • 80 citations

Mapping rat brain structures activated during ethanol withdrawal: role of glutamate and NMDA receptors

1992 • 71 citations

N-methyl-d-aspartic acid biphasically regulates the biochemical and electrophysiological response of A10 dopamine neurons in the ventral tegmental area: in vivo microdialysis and in vitro electrophysiological studies

1994 • 67 citations

MK-801 prevents brain lesions and delayed-nonmatching-to-sample deficits produced by pyrithiamine-induced encephalopathy in rats.

1992 • 64 citations

Acamprosate and alcohol: III. Effects on alcohol discrimination in the rat

1996 • 62 citations

A correlation between voluntary ethanol consumption and brain catalase activity in the rat

1985 • 58 citations

Ethanol inhibits release of excitatory amino acids from slices of hippocampal area CA1

1992 • 47 citations

A Comparison of the Effects of Ethanol and the Competitive Glycine Antagonist 7‐Chlorokynurenic Acid on N‐Methyl‐<scp>d</scp>‐Aspartic Acid‐Induced Neurotransmitter Release from Rat Hippocampal Slices

1994 • 43 citations

Ethanol attenuates the response of locus coeruleus neurons to excitatory amino acid agonists in vivo

1992 • 43 citations

NMDA receptors excite alcohol research

1990 • 43 citations

Role of NMDA and non-NMDA receptors in the nucleus tractus solitarius in the depressant effect of ethanol on baroreflexes.

1993 • 38 citations

Ethanol action on excitatory amino acid activated ion channels.

1993 • 36 citations

Blockade of l-glutamate receptors in the rostral ventrolateral medulla contributes to ethanol-evoked impairment of baroreflexes in conscious rats

1995 • 30 citations

Effects of 250 mg% ethanol on monoamine and amino acid release from rat striatal slices

1985 • 26 citations

The effects of chronic ethanol exposure on N-methyl-d-aspartate-stimulated overflow of [3H]catecholamines from rat brain

1991 • 24 citations

Effects of Prenatal Ethanol Exposure on Hippocampal Ionotropic‐Quisqualate and Kainate Receptors

1992 • 22 citations

Alteration of [³H]MK‐801 Binding Associated with the JV‐Methyl‐<scp>d</scp>‐Aspartate Receptor Complex by Acute Ethanol in Rat Cortex and Hippocampus In Vitro

1995 • 17 citations

Glutamate receptor changes in brain synaptic membranes during chronic alcohol intake.

1993 • 16 citations