Myeloperoxidase Deficiency

[136] Assay of catalases and peroxidases

1955 • 4,049 citations

Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture

1977 • 2,134 citations

Human promyelocytic leukemia cells in culture differentiate into macrophage-like cells when treated with a phorbol diester.

1979 • 1,019 citations

Studies on the chlorinating activity of myeloperoxidase.

1976 • 918 citations

LYSOSOMAL ENZYMES AND THEIR RECEPTORS

1986 • 915 citations

Characterization of the continuous, differentiating myeloid cell line (HL-60) from a patient with acute promyelocytic leukemia

1979 • 905 citations

Assay method for myeloperoxidase in human polymorphonuclear leukocytes

1983 • 867 citations

Myeloperoxidase-Halide-Hydrogen Peroxide Antibacterial System

1968 • 840 citations

Biosynthesis of lysosomal enzymes in fibroblasts. Synthesis as precursors of higher molecular weight.

1980 • 809 citations

Chlorination of Taurine by Human Neutrophils

1982 • 794 citations

Prolonged Granulocytopenia: The Major Risk Factor for Invasive Pulmonary Aspergillosis in Patients with Acute Leukemia

1984 • 772 citations

Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection

1969 • 697 citations

endo-beta-N-acetylglucosaminidase F: endoglycosidase from Flavobacterium meningosepticum that cleaves both high-mannose and complex glycoproteins.

1982 • 689 citations

Brief Report: Simplified Myeloperoxidase Stain Using Benzidine Dihydrochloride

1965 • 673 citations

Glycoproteins

1972 • 582 citations

Oxidative Autoactivation of Latent Collagenase by Human Neutrophils

1985 • 466 citations

A hypothesis for I-cell disease: Defective hydrolases that do not enter lysosomes

1972 • 446 citations

Biological reactivity of hypochlorous acid: implications for microbicidal mechanisms of leukocyte myeloperoxidase.

1981 • 443 citations

Chemiluminescence and superoxide production by myeloperoxidase-deficient leukocytes.

1976 • 373 citations

Myeloperoxidase: Contribution to the Microbicidal Activity of Intact Leukocytes

1970 • 345 citations

Neutrophil-mediated tumor cell cytotoxicity: role of the peroxidase system.

1975 • 317 citations

RESOLUTION OF GRANULES FROM RABBIT HETEROPHIL LEUKOCYTES INTO DISTINCT POPULATIONS BY ZONAL SEDIMENTATION

1969 • 311 citations

In vitro suppression of serum elastase-inhibitory capacity by reactive oxygen species generated by phagocytosing polymorphonuclear leukocytes.

1979 • 293 citations

Chloramines as intermediates of oxidation reaction of amino acids by myeloperoxidase

1971 • 272 citations

Enzymatic inactivation of human alpha-1-proteinase inhibitor by neutrophil myeloperoxidase

1979 • 270 citations

Optimizing hydrolysis of N-linked high-mannose oligosaccharides by endo-β-N-acetylglucosaminidase H

1984 • 270 citations

Potential Mediator of Inflammation

1980 • 255 citations

Neutrophils degrade subendothelial matrices in the presence of alpha-1-proteinase inhibitor. Cooperative use of lysosomal proteinases and oxygen metabolites.

1984 • 253 citations

Myeloperoxidase Deficiency

1981 • 246 citations

Characterization and quantification of the peroxidase in human monocytes

1978 • 238 citations

Role of myeloperoxidase-mediated antimicrobial systems in intact leukocytes.

1972 • 236 citations

Antifungal Effects of Peroxidase Systems

1969 • 233 citations

Myeloperoxidase-catalyzed inactivation of alpha 1-protease inhibitor by human neutrophils.

1981 • 222 citations

Substitute for Benzidine in Myeloperoxidase Stains

1975 • 219 citations

Damage to hyphal forms of fungi by human leukocytes in vitro. A possible host defense mechanism in aspergillosis and mucormycosis.

1978 • 209 citations

Peroxidase-Mediated Virucidal Systems

1970 • 198 citations

Damage to Pseudohyphal Forms of Candida albicans by Neutrophils in the Absence of Serum In Vitro

1978 • 196 citations

The reductive cleavage of myeloperoxidase in half, producing enzymically active hemi-myeloperoxidase.

1981 • 196 citations

The fungicidal mechanisms of human monocytes. I. Evidence for myeloperoxidase-linked and myeloperoxidase-independent candidacidal mechanisms.

1975 • 191 citations

Isolation procedure and some properties of myeloperoxidase from human leucocytes

1978 • 190 citations

Identification and characterization of cells deficient in the mannose 6-phosphate receptor: evidence for an alternate pathway for lysosomal enzyme targeting.

1983 • 186 citations

Myeloperoxidase: its structure and expression during myeloid differentiation

1985 • 184 citations

Characterization of cDNA clones for human myeloperoxidase: Predicted amino acid sequence and evidence for multiple mRNA species

1987 • 169 citations

Peroxidase-H2O2-halide system: Cytotoxic effect on mammalian tumor cells

1975 • 169 citations

Myeloperoxidase-Hydrogen Peroxide-Chloride Antimicrobial System: Effect of Exogenous Amines on Antibacterial Action Against Escherichia coli

1979 • 168 citations

Termination of the Respiratory Burst in Human Neutrophils

1978 • 168 citations

Role of myeloperoxidase in the respiratory burst of human neutrophils

1983 • 167 citations

Further evidence for a non‐random chromosomal abnormality in acute promyelocytic leukemia

1977 • 165 citations

Damage to Candida albicans Hyphae and Pseudohyphae by the Myeloperoxidase System and Oxidative Products of Neutrophil Metabolism In Vitro

1980 • 162 citations

Monocyte and granulocyte-mediated tumor cell destruction. A role for the hydrogen peroxide-myeloperoxidase-chloride system.

1982 • 159 citations

Generation of nitrogen-chlorine oxidants by human phagocytes.

1984 • 156 citations

Studies on the Mechanism of Antibody-Dependent Polymorphonuclear Leukocyte-Mediated Cytotoxicity

1977 • 148 citations

Role of monochloramine in the oxidation of erythrocyte hemoglobin by stimulated neutrophils.

1984 • 144 citations

Myeloperoxidase Deficiency

1970 • 143 citations

Molecular cloning and characterization of cDNA for human myeloperoxidase.

1987 • 142 citations

Purification of myeloperoxidases from bone marrow

1969 • 140 citations

Hydrogen peroxide utilization in myeloperoxidase-deficient leukocytes: a possible microbicidal control mechanism

1971 • 140 citations

Defective Bactericidal Activity in Myeloperoxidase-deficient Human Neutrophils

1969 • 139 citations

Chemotactic Factor Inactivation by the Myeloperoxidase-Hydrogen Peroxide-Halide System

1979 • 136 citations

Multiple forms of myeloperoxidase from human neutrophilic granulocytes: Evidence for differences in compartmentalization, enzymatic activity, and subunit structure

1983 • 134 citations

Nonoxidative Fungicidal Mechanisms of Mammalian Granulocytes: Demonstration of Components with Candidacidal Activity in Human, Rabbit, and Guinea Pig Leukocytes

1975 • 132 citations

Myeloperoxidase-catalyzed incorporation of amines into proteins: role of hypochlorous acid and dichloramines

1982 • 132 citations

Oxidation of chloride and thiocyanate by isolated leukocytes.

1986 • 129 citations

Mechanisms of Attachment of Neutrophils to Candida albicans Pseudohyphae in the Absence of Serum, and of Subsequent Damage to Pseudohyphae by Microbicidal Processes of Neutrophils In Vitro

1978 • 126 citations

Myeloperoxidase‐Mediated Iodination in Granulocytes

1972 • 125 citations

Interaction of human .alpha.-1-proteinase inhibitor with neutrophil myeloperoxidase

1981 • 119 citations

Functional Aspects of a Second Mechanism of Candidacidal Activity by Human Neutrophils

1972 • 116 citations

Biochemical and Immunologic Analysis of Hereditary Myeloperoxidase Deficiency

1983 • 115 citations

Myeloperoxidase modulates the phagocytic activity of polymorphonuclear neutrophil leukocytes. Studies with cells from a myeloperoxidase-deficient patient.

1984 • 114 citations

Role of Cell-generated Hydrogen Peroxide in Granulocyte-mediated Killing of Schistosomula of Schistosoma mansoni In Vitro

1981 • 113 citations

Studies in Batten Disease

1974 • 111 citations

PEROXIDASE-MEDIATED MAMMALIAN CELL CYTOTOXICITY

1973 • 109 citations

Immunomodulation by neutrophil myeloperoxidase and hydrogen peroxide: differential susceptibility of human lymphocyte functions.

1986 • 104 citations

Neutrophil-platelet interaction mediated by myeloperoxidase and hydrogen peroxide.

1980 • 100 citations

Phagocytosing human neutrophils inactivate their own granular enzymes.

1981 • 98 citations

Myeloperoxidase biosynthesis by a human promyelocytic leukemia cell line: insight into myeloperoxidase deficiency

1986 • 98 citations

Hereditary myeloperoxidase deficiency

1981 • 98 citations

The subunit structure of crystalline canine myeloperoxidase

1977 • 92 citations

Mechanisms of Destruction of Aspergillus fumigatus Hyphae Mediated by Human Monocytes

1983 • 89 citations

Leukocyte candidacidal activity and resistance to systemic candidiasis in patients with cancer

1971 • 87 citations

Leukocyte myeloperoxidase deficiency and diabetes mellitus associated with Candida albicans liver abscess

1979 • 83 citations

Human eosinophil peroxidase: a novel isolation procedure, spectral properties and chlorinating activity

1981 • 82 citations

Lysosomal enzyme oligosaccharide phosphorylation in mouse lymphoma cells: specificity and kinetics of binding to the mannose 6-phosphate receptor in vivo

1982 • 82 citations

Induction of differentiation in a human promyelocytic leukemic cell line (HL-60) *1Production of granule proteins

1981 • 81 citations

Chemotactic factor inactivation by myeloperoxidase-mediated oxidation of methionine.

1980 • 80 citations

Quantitative determination of myeloperoxidase using tetramethylbenzidine as substrate

1982 • 80 citations

Eosinophils versus Neutrophils in Host Defense

1979 • 78 citations

Regulation of myeloperoxidase gene expression during differentiation of human myeloid leukemia HL-60 cells.

1984 • 78 citations

Purification and characterization of small molecular weight myeloperoxidase from human promyelocytic leukemia HL-60 cells

1981 • 77 citations

Mast Cell Granule Peroxidase: Location, Secretion, and SRS-A Inactivation

1979 • 77 citations

Studies on the subunits of human myeloperoxidase

1984 • 77 citations

Analysis of the peptide subunits of human neutrophil myeloperoxidase

1986 • 77 citations

Structural analysis of myeloperoxidase by resonance Raman spectroscopy

1984 • 76 citations

Mechanisms of Killing of Newborn Larvae of Trichinella spiralis by Neutrophils and Eosinophils

1979 • 76 citations

Myeloperoxidase is synthesized as larger phosphorylated precursor.

1984 • 74 citations

Neutrophils autoinactivate secretory products by myeloperoxidase- catalyzed oxidation

1985 • 73 citations

Chlorinating Ability of Human Phagocytosing Leucocytes

1975 • 71 citations

Refractory Megaloblastic Anemia with Myeloperoxidase-Deficient Neutrophils

1972 • 71 citations

Raman characterization of human leukocyte myeloperoxidase and bovine spleen green haemoprotein. Insight into chromophore structure and evidence that the chromophores of myeloperoxidase are equivalent

1985 • 71 citations

Inactivation of Bronchial Mucous Proteinase Inhibitor by Cigarette Smoke and Phagocyte-Derived Oxidants

1980 • 70 citations

Monocyte-mediated Serum-independent Damage to Hyphal and Pseudohyphal Forms of Candida albicans In Vitro

1981 • 70 citations

Myeloperoxidase--H2O2--halide system: cytotoxic effect on human blood leukocytes

1977 • 69 citations

Biosynthesis, transport and processing of myeloperoxidase in the human leukaemic promyelocytic cell line HL-60 and normal marrow cells

1984 • 69 citations

Killing of Aspergillus fumigatus spores and Candida albicans yeast phase by the iron-hydrogen peroxide-iodide cytotoxic system: comparison with the myeloperoxidase-hydrogen peroxide-halide system

1984 • 69 citations

cDNA cloning of human myeloperoxidase: decrease in myeloperoxidase mRNA upon induction of HL-60 cells.

1987 • 69 citations

Differential distribution of distinct forms of myeloperoxidase in different azurophilic granule subpopulations from human neutrophils

1983 • 68 citations

RNA and protein synthesis in human peripheral blood polymorphonuclear leukocytes.

1979 • 67 citations

Posttranslational processing of a human myeloid lysosomal protein, myeloperoxidase

1987 • 66 citations

Role of the Phagocyte in Host-Parasite Interactions XXVII. Myeloperoxidase-H ₂ O ₂ -Cl ⁻ -Mediated Aldehyde Formation and Its Relationship to Antimicrobial Activity

1971 • 66 citations

Die Alius-Grignaschi-Anomalie: Der erblich-konstitutionelle Peroxydasedefekt der Neutrophilen und Monozyten

1966 • 66 citations

Chemotactic factor inactivation by stimulated human neutrophils mediated by myeloperoxidase-catalyzed methionine oxidation.

1982 • 66 citations

Synthesis and Processing of Arylsulfatase A in Human Skin Fibroblasts

1982 • 65 citations

Myeloperoxidase: Confirmation and nature of heme-binding inequivalence

1978 • 65 citations

Hereditary myeloperoxidase deficiency

1979 • 63 citations

Role of the Phagocyte in Host-Parasite Interactions XXIV. Aldehyde Generation by the Myeloperoxidase-H ₂ O ₂ -Chloride Antimicrobial System: a Possible In Vivo Mechanism of Action

1970 • 62 citations

Human myeloperoxidase gene: molecular cloning and expression in leukemic cells

1986 • 61 citations

Crystallization and Properties of Myeloperoxidase from Normal Human Leukocytes

1986 • 61 citations

Processing of a newly identified intermediate of human myeloperoxidase in isolated granules occurs at neutral pH.

1986 • 61 citations

Oxidation of Escherichia coli iron centers by the myeloperoxidase-mediated microbicidal system.

1982 • 60 citations

Synthesis and transport of lysosomal acid phosphatase in normal and I-cell fibroblasts.

1985 • 60 citations

Biosynthesis, processing, and secretion of M and Z variant human alpha 1-antitrypsin.

1986 • 59 citations

Phorbol myristate acetate induced neutrophil autotoxicity

1980 • 58 citations

STUDIES ON PEROXIDATIVE DETOXIFICATION OF PURIFIED DIPHTHERIA TOXIN

1950 • 58 citations

Chemotactic factors trigger their own oxidative inactivation by human neutrophils.

1982 • 58 citations

Resonance Raman evidence of chloride binding to the heme iron in myeloperoxidase

1985 • 57 citations

Intact form of myeloperoxidase from normal human neutrophils

1982 • 57 citations

Myeloperoxidase-Mediated Platelet Release Reaction

1979 • 56 citations

Candidacidal activity of myeloperoxidase: mechanisms of inhibitory influence of soluble cell wall mannan

1983 • 54 citations

Oxidation of lysine side-chains of elastin by the myeloperoxidase system and by stimulated human neutrophils

1986 • 54 citations

Myeloperoxidase of the leukocyte of normal blood IV. Some physicochemical properties

1972 • 54 citations

Characterization of the Peroxidase in Human Eosinophils

1980 • 53 citations

Oxidation of microbial iron-sulfur centers by the myeloperoxidase-H2O2-halide antimicrobial system

1985 • 52 citations

Differences in myeloperoxidase activity from neutrophilic polymorphonuclear leukocytes of differing density: relationship to selective exocytosis of distinct forms of the enzyme

1983 • 51 citations

Oxidation of n-formyl methionyl chemotactic peptide by human neutrophils.

1981 • 50 citations

Incidence of myeloperoxidase deficiency in an area of northern Italy: histochemical, biochemical and functional studies

1982 • 49 citations

A Study of the Molecular Pathology of Sucrase-Isomaltase Deficiency

1987 • 49 citations

Impaired Neutrophil Function and Myeloperoxidase Deficiency in Pregnancy

1980 • 49 citations

Effects of ammonia on processing and secretion of precursor and mature lysosomal enzyme from macrophages of normal and pale ear mice: evidence for two distinct pathways.

1985 • 48 citations

Miscleavage at the presequence of rat preprolactin synthesized in pituitary cells incubated with a threonine analog

1981 • 48 citations

Localization of myeloperoxidase to the long arm of human chromosome 17: relationship to the 15; 17 translocation of acute promyelocytic leukemia.

1987 • 47 citations

Detoxicating Effect of Verdoperoxidase on Toxins

1947 • 45 citations

Evidence that myeloperoxidase is composed of isoenzymes

1972 • 43 citations

Similarity of kinetics of three types of myeloperoxidase from human leukocytes and four types from HL-60 cells

1986 • 43 citations

Comparison of myeloperoxidase and hemi-myeloperoxidase with respect to catalysis, regulation, and bactericidal activity

1984 • 43 citations

New approaches to the detection of myeloperoxidase deficiency

1982 • 41 citations

Increased respiratory burst in myeloperoxidase-deficient monocytes

1983 • 41 citations

Evidence for and partial characterization of three major and three minor chromatographic forms of human neutrophil myeloperoxidase

1986 • 41 citations

Down-regulation of human natural killer activity against tumors by the neutrophil myeloperoxidase system and hydrogen peroxide.

1984 • 41 citations

The role of the phagocyte in host-parasite interactions. XXIII. Relation of bactericidal activity to peroxidase-associated decarboxylation and deamination

1970 • 38 citations

Function of Granulocytes with Deficient Myeloperoxidase‐Mediated Iodination in a Patient with Generalized Pustular Psoriasis

1976 • 36 citations

Human neutrophils transform prostaglandins by a myeloperoxidase-dependent mechanism.

1982 • 35 citations

Inactivation of Clostridium difficile Cytotoxin by the Neutrophil Myeloperoxidase System

1984 • 34 citations

Some enzymatic characteristics of eosinophil peroxidase from patients with eosinophilia and from healthy donors

1981 • 34 citations

Oxidative inactivation of pneumolysin by the myeloperoxidase system and stimulated human neutrophils.

1986 • 32 citations

Inactivation of lysosomal enzymes by the respiratory burst of polymorphonuclear leukocytes. Possible involvement of myeloperoxidase-H2O2-halide system.

1982 • 31 citations

Neutrophil myeloperoxidase: a simple, reproducible technique to determine activity.

1979 • 31 citations

Myeloperoxidase‐deficient polymorphonuclear leucocytes (V): Relation to FAB‐classification and neutrophil alkaline phosphatase activity in primary myelodysplastic syndromes

1985 • 30 citations

Separation and analysis of subcellular organelles in a human promyelocytic leukemia cell line, HL-60: application to the study of myeloid lysosomal enzyme synthesis and processing

1986 • 29 citations

Studies on the mechanism of metabolic stimulation in polymorphonuclear leucocytes during phagocytosis II. Presence of the NADPH2 oxidizing activity in a myeloperoxidase-deficient subject

1975 • 29 citations

Hereditary Myeloperoxidase Deficiency: Study of 12 Cases

1982 • 28 citations

Phorbol myristate acetate-induced neutrophil autotoxicity

1980 • 27 citations

Isolation of three native forms of myeloperoxidase from human polymorphonuclear leukocytes

1982 • 27 citations

A Rapid, Sensitive Myeloperoxidase Stain Using 4-Chloro-1-naphthol

1980 • 27 citations

Myeloperoxidase reduces the opsonizing activity of immunoglobulin G and complement component C3b

1984 • 26 citations

Molecular forms of myeloperoxidase in human plasma

1986 • 25 citations

The egasyn gene affects the processing of oligosaccharides of lysosomal β-glucuronidase in liver

1986 • 25 citations

Myeloperoxidase‐Deficient Polymorphonuclear Leucocytes

1983 • 23 citations

Oxidative inactivation of Actinobacillus actinomycetemcomitans leukotoxin by the neutrophil myeloperoxidase system

1986 • 23 citations

Characterization of hereditary partial myeloperoxidase deficiency.

1982 • 22 citations

The Effect of Transfer Factor on Neutrophil Function in Chronic Mucocutaneous Candidiasis

1976 • 21 citations

Influence of yeast mannan on release of myeloperoxidase by human neutrophils: determination of structural features of mannan required for formation of myeloperoxidase-mannan-neutrophil complexes

1984 • 21 citations

Myeloperoxidase‐Deficient Polymorphonuclear Leucocytes

1983 • 21 citations

Myeloperoxidase‐deficient polymorphonuclear leucocytes (VII): Incidence in untreated myeloproliferative disorders

1986 • 21 citations

Biochemical characterization of human myeloperoxidase using three specific monoclonal antibodies

1986 • 20 citations

TREATMENT OF MUCOCUTANEOUS CANDIDIASIS WITH TRANSFER FACTOR

1974 • 19 citations

Increased degranulation of human myeloperoxidase‐deficient polymorphonuclear leucocytes

1985 • 19 citations

Partial Peroxidase Deficiency in Neutrophils and Eosinophils Associated with Neurologic Dise: Histochemical, Cytochemical and Biochemical Studies

1980 • 18 citations

Myeloperoxidase VIII: Separation into ten components by free-flow electrophoresis

1967 • 18 citations

Partial myeloperoxidase deficiency in preleukemia

1983 • 17 citations

Partial Myeloperoxidase Deficiency

1982 • 17 citations

Acquired neutrophil myeloperoxidase deficiency: an indicator of subclinical activation of blood coagulation?

1983 • 17 citations

A Case with Hematological Abnormality Characterized by the Absence of Peroxidase Activity in Blood Polymorphonuclear Leukocytes

1965 • 16 citations

Abnormal neutrophil myeloperoxidase from a patient with chronic myelocytic leukemia

1982 • 16 citations

Uracil-uric Refractory Anemia with Peroxidase Negative Neutrophils

1965 • 14 citations

Familiärer Myeloperoxidasedefekt und akute myeloische Leukämie

1978 • 14 citations

Myeloperoxidases of Human Myeloid Leukemia Cells HL-60 Grown in Culture and in Nude Mice1

1983 • 14 citations

PRIMARY MYELOPEROXIDASE DEFICIENCY ASSOCIATED WITH IMPAIRED NEUTROPHIL MARGINATION AND CHEMOTAXIS

2008 • 13 citations

Induction of myeloperoxidase deficiency in granulocytes in lead- intoxicated dogs

1979 • 12 citations

Separation of leukocyte peroxidase isoenzymes by agarose-acrylamide disc electrophoresis

1978 • 12 citations

Regulation of Myeloperoxidase Gene Expression by the Tumor Promoter 12-O-Tetradecanoylphorbol-13-Acetate in Human Leukemia HL-60 Cells1

1986 • 12 citations

Myeloperoxidase‐deficient polymorphonuclear leucocytes (VI): Relation to cytogenetic abnormalities in primary myelodysplastic syndromes

1986 • 11 citations

Myeloperoxidase-mediated modulation of chemotactic peptide binding to human neutrophils

1983 • 11 citations

Disseminated candidiasis in a previously healthy girl: Implication of a leukocyte candidacidal defect

1977 • 11 citations

Myeloperoxidase-deficient polymorphonuclear leucocytes (IV): Relation to FAB-classification in acute myeloid leukaemia

1985 • 10 citations

Myeloperoxidase-deficient polymorphonuclear leucocytes. Longitudinal study during the preremission ? and the remission phase in acute myeloid leukaemia

1986 • 9 citations

Granulocytenfunktionsdefekte bei granulomat�ser muco-cutaner candidiasis

1975 • 9 citations

Myeloperoxidase‐deficient polymorphonuclear leucocytes (III): Relation to incidence of infection in acute myeloid leukaemia

1984 • 7 citations

Der Myeloperoxidase-Mangel als Ursache rezidivierender Infektionen*

1985 • 6 citations

Influence of myeloperoxidase (MPO) on neutrophil functions: studies with MPO-deficient neutrophils (PMN)

1984 • 2 citations

Mechanism and Structural Basis for Recognition of Signal Peptides

1986 • 1 citations