Ca2+ As a Second Messenger within Mitochondria of the Heart and other Tissues

INTRACELLULAR CALCIUM HOMEOSTASIS

1987 • 2,183 citations

Fluorescence and bioluminescence measurement of cytoplasmic free calcium

1987 • 522 citations

Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase

1972 • 519 citations

Mitochondrial calcium transport

1982 • 486 citations

The regulation of the matrix volume of mammalian mitochondria in vivo and in vitro and its role in the control of mitochondrial metabolism

1989 • 443 citations

The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex

1979 • 431 citations

Relation between mitochondrial calcium transport and control of energy metabolism

1985 • 362 citations

Calcium ions and the regulation of NAD+-linked isocitrate dehydrogenase from the mitochondria of rat heart and other tissues

1978 • 359 citations

Kinetic evidence for a heart mitochondrial pore activated by Ca²⁺, inorganic phosphate and oxidative stress

1988 • 293 citations

Role of calcium ions in the regulation of intramitochondrial metabolism. Effects of Na+, Mg2+ and ruthenium red on the Ca2+-stimulated oxidation of oxoglutarate and on pyruvate dehydrogenase activity in intact rat heart mitochondria

1980 • 292 citations

Regulation of free and bound magnesium in rat hepatocytes and isolated mitochondria.

1986 • 290 citations

Ca2+ transport by mammalian mitochondria and its role in hormone action

1985 • 242 citations

Respiratory control in the glucose perfused heart

1987 • 141 citations

Regulation of NAD+-linked isocitrate dehydrogenase and 2-oxoglutarate dehydrogenase by Ca2+ ions within toluene-permeabilized rat heart mitochondria. Interactions with regulation by adenine nucleotides and NADH/NAD+ ratios

1988 • 124 citations

The regulation of the oxidation of fatty acids and other substrates in rat heart mitochondria by changes in the matrix volume induced by osmotic strength, valinomycin and Ca2+

1987 • 121 citations

Purification and properties of pyruvate dehydrogenase phosphatase from bovine heart and kidney

1982 • 115 citations

³¹P‐NMR studies of respiratory regulation in the intact myocardium

1986 • 111 citations

Studies on mitochondrial Ca2+-transportand matrix Ca2+ using fura-2-loaded rat heart mitochondria

1989 • 103 citations

The Regulation of Mitochondrial Calcium Transport in Heart

1985 • 102 citations

Role of Ca2+ in pyruvate dehydrogenase interconversion in brain mitochondria and synaptosomes

1985 • 89 citations

Direct evidence for a role of intramitochondrial Ca2+ in the regulation of oxidative phosphorylation in the stimulated rat heart. Studies using31P n.m.r. and ruthenium red

1989 • 84 citations

Relation between cytosolic free Ca2+ concentration and the control of pyruvate dehydrogenase in isolated cardiac myocytes

1987 • 83 citations

Measurement of the matrix free Ca2+ concentration in heart mitochondria by entrapped fura-2 and quin2

1987 • 82 citations

Intramitochondrial and extramitochondrial free calcium ion concentrations of suspensions of heart mitochondria with very low, plausibly physiological, contents of total calcium

1982 • 82 citations

Exchangeable and total calcium pools in mitochondria of rat epididymal fat-pads and isolated fat-cells. Role in the regulation of pyruvate dehydrogenase activity

1976 • 74 citations

Effect of micromolar concentrations of free Ca2+ ions on pyruvate dehydrogenase interconversion in intact rat heart mitochondria

1981 • 69 citations

The α-adrenergic-mediated activation of the cardiac mitochondrial Ca2+ uniporter and its role in the control of intramitochondrial Ca2+in vivo

1983 • 68 citations

The activation of pyruvate dehydrogenase in the perfused rat heart by adrenaline and other inotropic agents

1981 • 68 citations

Calcium and plant organelles

1984 • 63 citations

Role of Ca2+ ions in the regulation of intramitochondrial metabolism in rat epididymal adipose tissue. Evidence against a role for Ca2+ in the activation of pyruvate dehydrogenase by insulin

1984 • 60 citations

Effect of fatty acids and ketones on the activity of pyruvate dehydrogenase in skeletal-muscle mitochondria

1983 • 59 citations

Inorganic pyrophosphate is located primarily in the mitochondria of the hepatocyte and increases in parallel with the decrease in light-scattering induced by gluconeogenic hormones, butyrate and ionophore A23187

1988 • 54 citations

Activation of pyruvate dehydrogenase in the perfused rat liver by vasopressin

1978 • 54 citations

Inhibition of bovine kidney .alpha.-ketoglutarate dehydrogenase complex by reduced nicotinamide adenine dinucleotide in the presence or absence of calcium ion and effect of adenosine 5'-diphosphate on reduced nicotinamide adenine dinucleotide inhibition

1981 • 53 citations

Cell calcium measurement with electron probe and electron energy loss analysis

1985 • 49 citations

Some aspects of the kinetics of rat liver pyruvate carboxylase

1970 • 44 citations

Ca2+-regulated release of an ATPase inhibitor protein from submitochondrial particles derived from skeletal muscles of the rat.

1980 • 38 citations

Comparative Studies on the Influence of Hormones on Metabolite Compartmentation in Isolated Liver Cells during Gluconeogenesis from Lactate

1978 • 34 citations

Effect of micromolar Ca2+ on NADH inhibition of bovine kidney ?-ketoglutarate dehydrogenase complex and possible role of Ca2+ in signal amplification

1980 • 33 citations

Evidence for the regulation of the branched chain .alpha.-keto acid dehydrogenase multienzyme complex by a phosphorylation/dephosphorylation mechanism

1982 • 30 citations

Inhibition of Ca2+ of carbamoylphosphate synthetase (ammonia).

1981 • 28 citations

Role of calcium as an inhibitor of rat liver carbamylphosphate synthetase I.

1984 • 20 citations

Effects of adrenergic agonists and mitochondrial energy state on the calcium transport systems of mitochondria

1987 • 15 citations

Role of calcium in synaptosomal substrate oxidation

1988 • 11 citations

On the hormonal control of heart mitochondrial Ca2+.

1985 • 10 citations