Sensitization of high mechanothreshold superficial dorsal horn and flexor motor neurones following chemosensitive primary afferent activation

The induction and maintenance of central sensitization is dependent on N -methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states

1991 • 1,963 citations

Sensory Mechanisms of the Spinal Cord

1978 • 1,473 citations

Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.

1969 • 1,011 citations

Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms

1991 • 942 citations

Activity-dependent neuronal plasticity following tissue injury and inflammation

1992 • 933 citations

Sensory Mechanisms of the Spinal Cord

1991 • 920 citations

Central changes in processing of mechanoreceptive input in capsaicin‐induced secondary hyperalgesia in humans.

1992 • 785 citations

Hyperalgesia Mediated by Spinal Glutamate or Substance P Receptor Blocked by Spinal Cyclooxygenase Inhibition

1992 • 725 citations

Dynamic receptive field plasticity in rat spinal cord dorsal horn following C-primary afferent input

1987 • 667 citations

Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons

1991 • 616 citations

Relative effectiveness of C primary afferent fibers of different origins in evoking a prolonged facilitation of the flexor reflex in the rat

1986 • 561 citations

Comparative study of perceived pain and nociceptive flexion reflex in man

1977 • 560 citations

Dynamic and static components of mechanical hyperalgesia in human hairy skin

1992 • 510 citations

Muscle but not cutaneous C‐afferent input produces prolonged increases in the excitability of the flexion reflex in the rat.

1984 • 500 citations

Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia

1991 • 453 citations

Expansion of receptive fields of spinal lamina I projection neurons in rats with unilateral adjuvant-induced inflammation: the contribution of dorsal horn mechanisms

1989 • 395 citations

Morphological features of functionally defined neurons in the marginal zone and substantia gelatinosa of the spinal dorsal horn

1979 • 378 citations

EVIDENCE FOR DIFFERENT MECHANISMS OF PRIMARY AND SECONDARY HYPERALGESIA FOLLOWING HEAT INJURY TO THE GLABROUS SKIN

1984 • 282 citations

Long term alterations in the excitability of the flexion reflex produced by peripheral tissue injury in the chronic decerebrate rat

1984 • 274 citations

Dynamic alterations in the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat spinal cord

1990 • 272 citations

Response of unmyelinated (C) polymodal nociceptors to thermal stimuli applied to monkey's face

1976 • 261 citations

Stimulation of craniofacial muscle afferents induces prolonged facilitatory effects in trigeminal nociceptive brain-stem neurones

1992 • 253 citations

Enhanced responses of spinothalamic tract neurons to excitatory amino acids accompany capsaicin-induced sensitization in the monkey

1992 • 220 citations

Evidence for a central component in the sensitization of spinal neurons with joint input during development of acute arthritis in cat's knee

1990 • 213 citations

Chemosensitivity and sensitization of nociceptive afferents that innervate the hairy skin of monkey

1993 • 181 citations

Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: a comparison of neural events in monkey with sensory judgments in human

1983 • 179 citations

Receptive fields of rat lamina 1 projection cells move to incorporate a nearby region of injury

1984 • 176 citations

Generation of acute pain: Central mechanism

1991 • 174 citations

Changes in tonic descending inhibition of spinal neurons with articular input during the development of acute arthritis in the cat

1991 • 165 citations

Neurophysiological characterization of the anterolateral spinal cord neurons contributing to pain perception in man

1975 • 154 citations

Functional relationships between neurons of marginal and substantia gelatinosa layers of primate dorsal horn

1979 • 154 citations

Central neural mediators of secondary hyperalgesia following heat injury in rats: Neuropeptides and excitatory amino acids

1991 • 151 citations

Spinal Afferent Processing

1987 • 145 citations

Long-term changes in discharge behaviour of cat dorsal horn neurones following noxious stimulation of deep tissues

1989 • 144 citations

Sensitization of cat dorsal horn neurons to innocuous mechanical stimulation after intradermal injection of capsaicin

1989 • 139 citations

Sensitization of nociceptive cutaneous nerve fibers from the rat's tail by noxious mechanical stimulation

1987 • 117 citations

The Effects of NMDA Antagonists on Neuronal Activity in Cat Spinal Cord Evoked by Acute Inflammation in the Knee Joint

1991 • 117 citations

Effects of spinal kappa-opioid receptor agonists on the responsiveness of nociceptive superficial dorsal horn neurons

1991 • 110 citations

The correlation of monkey medullary dorsal horn neuronal activity and the perceived intensity of noxious heat stimuli

1989 • 109 citations

A comparative study of the changes in receptive-field properties of multireceptive and nocireceptive rat dorsal horn neurons following noxious mechanical stimulation

1989 • 108 citations

Subthreshold components of the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat lumbar spinal cord

1989 • 107 citations

Dynamic changes in the receptive field properties of spinal cord neurons with ankle input in rats with chronic unilateral inflammation in the ankle region

1993 • 103 citations

Small-caliber afferent inputs produce a heterosynaptic facilitation of the synaptic responses evoked by primary afferent A-fibers in the neonatal rat spinal cord in vitro

1993 • 102 citations

Intrathecal CP-96,345 blocks reflex facilitation induced in rats by substance P and C-fiber-conditioning stimulation

1992 • 91 citations

Injury-induced plasticity of the flexor reflex in chronic decerebrate rats

1985 • 84 citations

Responses of monkey medullary dorsal horn neurons during the detection of noxious heat stimuli

1989 • 82 citations

Aspects of Sensory Processing through Convergent Neurons

1986 • 77 citations

The detection and perceived intensity of noxious thermal stimuli in monkey and in human

1989 • 64 citations

Changes in the response states of primate spinothalamic tract cells caused by mechanical damage of the skin or activation of descending controls

1992 • 61 citations

Responses to heat of C-fiber nociceptors in monkey are altered by injury in the receptive field but not by adjacent injury

1988 • 57 citations

Mechanical allodynia

1993 • 52 citations

Morphology and somatotopy of the central arborizations of rapidly adapting glabrous skin afferents in the rat lumbar spinal cord

1993 • 51 citations

Cutaneous receptive field and morphological properties of hamstring flexor alpha‐motoneurones in the rat.

1985 • 44 citations

The 15-lipoxygenase product, 8R,15S-diHETE, stereospecifically sensitizes C-fiber mechanoheat nociceptors in hairy skin of rat

1990 • 43 citations

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