Treatment of intracranial gliomas with bone marrow—derived dendritic cells pulsed with tumor antigens

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

Enhancement of Antitumor Immunity by CTLA-4 Blockade

1996 • 3,585 citations

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

Vaccination of patients with B–cell lymphoma using autologous antigen–pulsed dendritic cells

1996 • 1,854 citations

GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells

1992 • 1,608 citations

Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity

1995 • 1,097 citations

Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo.

1996 • 922 citations

Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines.

1996 • 849 citations

Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo.

1996 • 561 citations

Survival rates in patients with primary malignant brain tumors stratified by patient age and tumor histological type: an analysis based on Surveillance, Epidemiology, and End Results (SEER) data, 1973–1991

1998 • 481 citations

Interactions of tumor necrosis factor with granulocyte-macrophage colony-stimulating factor and other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34+ progenitors in human bone marrow.

1992 • 452 citations

Bone Marrow–generated Dendritic Cells Pulsed with Tumor Extracts or Tumor RNA Induce Antitumor Immunity against Central Nervous System Tumors

1997 • 443 citations

Dendritic Cells as Adjuvants for Immune-mediated Resistance to Tumors

1997 • 432 citations

Blood–Brain Barrier in Physiology and Medicine

1977 • 395 citations

Dendritic Cells Genetically Modified with an Adenovirus Vector Encoding the cDNA for a Model Antigen Induce Protective and Therapeutic Antitumor Immunity

1997 • 390 citations

Expansion of immunostimulatory dendritic cells among the myeloid progeny of human CD34+ bone marrow precursors cultured with c-kit ligand, granulocyte-macrophage colony-stimulating factor, and TNF-alpha.

1995 • 350 citations

Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy.

1996 • 341 citations

Induction of antitumor immunity using bone marrow-generated dendritic cells.

1996 • 323 citations

Identification of T-Cell Epitopes

1993 • 232 citations

The MRC OX-62 antigen: a useful marker in the purification of rat veiled cells with the biochemical properties of an integrin.

1992 • 217 citations

Subcutaneous vaccination with irradiated, cytokine-producing tumor cells stimulates CD8+ cell-mediated immunity against tumors located in the "immunologically privileged" central nervous system.

1996 • 209 citations

Role of dendritic cells in the priming of CD4+ T lymphocytes to peptide antigen in vivo.

1993 • 164 citations

Generation of antimelanoma cytotoxic T lymphocytes from healthy donors after presentation of melanoma-associated antigen-derived epitopes by dendritic cells in vitro.

1995 • 157 citations

Peptide and protein antigens require distinct antigen-presenting cell subsets for the priming of CD4+ T cells.

1995 • 127 citations

Antitumor effects of granulocyte-macrophage colony-stimulating factor production by melanoma cells.

1996 • 112 citations

Bone marrow-derived dendritic cells pulsed with a tumor-specific peptide elicit effective anti-tumor immunity against intracranial neoplasms

1998 • 111 citations

Cytokines and immunoregulatory molecules in malignant glial neoplasms

1992 • 86 citations

Synergistic Effect of FLT-3 Ligand on the Granulocyte Colony-Stimulating Factor–Induced Mobilization of Hematopoietic Stem Cells and Progenitor Cells Into Blood in Mice

1997 • 80 citations

Prolonged survival of mice with glioma injected intracerebrally with double cytokine—secreting cells

1995 • 70 citations

Determination of cytotoxic T-lymphocyte precursor frequencies using europium labeling as a nonradioactive alternative to labeling with chromium-51

1992 • 61 citations

A fluorescence-based assay for quantitation of lymphokine-activated killer cell activity

1989 • 60 citations

A new protocol for the propagation of dendritic cells from rat bone marrow using recombinant GM-CSF, and their quantification using the mAb OX-62

1995 • 50 citations

Cell-surface marker analysis of rat thymic dendritic cells.

1993 • 43 citations

Interactions between lymphocytes, macrophages, and central nervous system cells

1994 • 40 citations

In vitro characterization of rat bone marrow-derived dendritic cells and their precursors

1996 • 34 citations

Biological approaches to cancer treatment: Biomodulation

1993 • 18 citations

Immunobiology of malignant astrocytomas.

1994 • 17 citations

CULTURE OF DENDRITIC CELLS FROM MURINE BONE MARROW SUPPLEMENTED WITH GM-CSF AND TNF-ALPHA

1994 • 14 citations