The biology of EBV infection in human epithelial cells

VIRUS PARTICLES IN CULTURED LYMPHOBLASTS FROM BURKITT'S LYMPHOMA

1964 • 2,643 citations

Epstein-Barr Virus

1986 • 2,255 citations

Epstein–Barr virus: 40 years on

2004 • 2,079 citations

Epstein-Barr virus and its replication

1996 • 1,621 citations

Epstein–Barr Virus in Burkitt's Lymphoma and Nasopharyngeal Carcinoma: EBV DNA in Biopsies of Burkitt Tumours and Anaplastic Carcinomas of the Nasopharynx

1970 • 1,261 citations

Epstein–Barr Virus Replication in Oropharyngeal Epithelial Cells

1984 • 741 citations

Focus on nasopharyngeal carcinoma

2004 • 546 citations

An Epstein-Barr virus–encoded microRNA targets PUMA to promote host cell survival

2008 • 447 citations

Alternate replication in B cells and epithelial cells switches tropism of Epstein–Barr virus

2002 • 445 citations

Identification and characterization of the Epstein-Barr virus receptor on human B lymphocytes and its relationship to the C3d complement receptor (CR2)

1985 • 343 citations

Cell-to-Cell Contact as an Efficient Mode of Epstein-Barr Virus Infection of Diverse Human Epithelial Cells

1998 • 314 citations

Replication of Epstein–Barr virus in human epithelial cells infected in vitro

1983 • 277 citations

Demonstration of a Herpes Group Virus in Cultures of Peripheral Leukocytes from Patients with Infectious Mononucleosis

1968 • 269 citations

Epstein-Barr virus infection of polarized tongue and nasopharyngeal epithelial cells

2003 • 269 citations

The Dynamics of EBV Shedding Implicate a Central Role for Epithelial Cells in Amplifying Viral Output

2009 • 257 citations

A New Model of Epstein-Barr Virus Infection Reveals an Important Role for Early Lytic Viral Protein Expression in the Development of Lymphomas

2010 • 255 citations

The Epstein–Barr virus nuclear antigen-1 promotes genomic instability via induction of reactive oxygen species

2009 • 226 citations

Immunoglobulin A-Induced Shift of Epstein-Barr Virus Tissue Tropism

1992 • 225 citations

Epstein–Barr virus infection and replication in a human epithelial cell system

1992 • 225 citations

Genome-Wide Expression Profiling Reveals EBV-Associated Inhibition of MHC Class I Expression in Nasopharyngeal Carcinoma

2006 • 215 citations

Clonal growth of epithelial cells from normal adult human bronchus.

1981 • 198 citations

Resting B cells as a transfer vehicle for Epstein–Barr virus infection of epithelial cells

2006 • 194 citations

Epstein-Barr Virus-Encoded LMP2A Induces an Epithelial–Mesenchymal Transition and Increases the Number of Side Population Stem-like Cancer Cells in Nasopharyngeal Carcinoma

2010 • 190 citations

Fusion of epithelial cells by Epstein–Barr virus proteins is triggered by binding of viral glycoproteins gHgL to integrins αvβ6 or αvβ8

2009 • 190 citations

Epstein-Barr Virus Infection Alters Cellular Signal Cascades in Human Nasopharyngeal Epithelial Cells

2006 • 187 citations

Establishment of two immortalized nasopharyngeal epithelial cell lines using SV40 large T and HPV16E6/E7 viral oncogenes

2002 • 182 citations

A Positive Autoregulatory Loop of LMP1 Expression and STAT Activation in Epithelial Cells Latently Infected with Epstein-Barr Virus

2003 • 164 citations

Linkage between STAT Regulation and Epstein-Barr Virus Gene Expression in Tumors

2001 • 156 citations

A Viral microRNA Cluster Strongly Potentiates the Transforming Properties of a Human Herpesvirus

2011 • 143 citations

Features Distinguishing Epstein-Barr Virus Infections of Epithelial Cells and B Cells: Viral Genome Expression, Genome Maintenance, and Genome Amplification

2009 • 120 citations

Fusion of Epstein-Barr Virus with Epithelial Cells Can Be Triggered by αvβ5 in Addition to αvβ6 and αvβ8, and Integrin Binding Triggers a Conformational Change in Glycoproteins gHgL

2011 • 119 citations

Expression of BARF1 gene encoded by Epstein-Barr virus in nasopharyngeal carcinoma biopsies.

2000 • 118 citations

Molecular and cytogenetic changes involved in the immortalization of nasopharyngeal epithelial cells by telomerase

2006 • 117 citations

Profile of cytokine expression in nasopharyngeal carcinomas: a distinct expression of interleukin 1 in tumor and CD4+ T cells.

1999 • 114 citations

Array-Based Comparative Genomic Hybridization Analysis Identified Cyclin D1 as a Target Oncogene at 11q13.3 in Nasopharyngeal Carcinoma

2005 • 113 citations

Epstein-Barr Virus Infection of Polarized Epithelial Cells via the Basolateral Surface by Memory B Cell-Mediated Transfer Infection

2011 • 107 citations

Requirement for Cell-to-Cell Contact in Epstein-Barr Virus Infection of Nasopharyngeal Carcinoma Cells and Keratinocytes

1999 • 105 citations

Epstein-Barr virus (EBV)-encodedBARF1 gene is expressed in nasopharyngeal carcinoma and EBV-associated gastric carcinoma tissues in the absence of lytic gene expression

2005 • 104 citations

A transforming function of the BARF1 gene encoded by Epstein-Barr virus.

1989 • 103 citations

Epstein-Barr Virus Latent Membrane Protein 1 Induces Cancer Stem/Progenitor-Like Cells in Nasopharyngeal Epithelial Cell Lines

2011 • 101 citations

Differential gene expression in nasopharyngeal carcinoma cells

2000 • 96 citations

Role of The Epstein–Barr Virus-Encoded Latent Membrane Protein-1, LMP1, in The Pathogenesis of Nasopharyngeal Carcinoma

2009 • 96 citations

Epstein–Barr Virus DNase (BGLF5) induces genomic instability in human epithelial cells

2009 • 93 citations

Recurrent chemical reactivations of EBV promotes genome instability and enhances tumor progression of nasopharyngeal carcinoma cells

2008 • 93 citations

Epstein‐Barr virus infection in immortalized nasopharyngeal epithelial cells: Regulation of infection and phenotypic characterization

2010 • 87 citations

Contributions of the Epstein-Barr Virus EBNA1 Protein to Gastric Carcinoma

2011 • 86 citations

Establishment of an oriP Replicon Is Dependent upon an Infrequent, Epigenetic Event

2001 • 84 citations

Cellular MicroRNAs 200b and 429 Regulate the Epstein-Barr Virus Switch between Latency and Lytic Replication

2010 • 81 citations

ZEB1 Regulates the Latent-Lytic Switch in Infection by Epstein-Barr Virus

2007 • 81 citations

Epstein-Barr Virus Transforming Protein LMP1 Plays a Critical Role in Virus Production

2005 • 74 citations

Suberoylanilide hydroxamic acid induces viral lytic cycle in Epstein‐Barr virus‐positive epithelial malignancies and mediates enhanced cell death

2009 • 72 citations

Epstein-Barr Virus BGLF4 Kinase Induces Premature Chromosome Condensation through Activation of Condensin and Topoisomerase II

2007 • 72 citations

In VitroProduction of Stable Epstein–Barr Virus-Positive Epithelial Cell Clones Which Resemble the Virus:Cell Interaction Observed in Nasopharyngeal Carcinoma

1996 • 66 citations

Quantitative Analysis of Epstein‐Barr Virus DNA in Plasma and Serum

2001 • 66 citations

Epstein‐Barr virus B95.8 produced in 293 cells shows marked tropism for differentiated primary epithelial cells and reveals interindividual variation in susceptibility to viral infection

2007 • 65 citations

The mechanism of Epstein-Barr virus infection in nasopharyngeal carcinoma cells.

1997 • 55 citations

Epstein–Barr virus BART gene expression

2009 • 55 citations

Stable expression of EBERs in immortalized nasopharyngeal epithelial cells confers resistance to apoptotic stress

2005 • 50 citations

Endoplasmic Reticulum Stress Triggers XBP-1–Mediated Up-regulation of an EBV Oncoprotein in Nasopharyngeal Carcinoma

2009 • 47 citations

Hairy leukoplakia: Epstein-Barr virus receptors on oral keratinocyte plasma membranes

1989 • 46 citations

Transforming Growth Factor β-Induced Reactivation of Epstein-Barr Virus Involves Multiple Smad-Binding Elements Cooperatively Activating Expression of the Latent-Lytic SwitchBZLF1Gene

2011 • 41 citations

Reconstitution of Nasopharyngeal Carcinoma–Type EBV Infection Induces Tumorigenicity

2008 • 40 citations

Epstein-Barr Virus Infection to Epstein-Barr Virus-Negative Nasopharyngeal Carcinoma Cell Line TW03 Enhances Its Tumorigenicity

2000 • 26 citations

Functional Analysis of EBV in Nasopharyngeal Carcinoma Cells

2003 • 25 citations

Two Epstein-Barr Virus Glycoprotein Complexes

2001 • 16 citations

Identification of genes differentially expressed in nasopharyngeal carcinoma by messenger RNA differential display.

1998 • 7 citations

IFN-α–Stimulated Genes and Epstein-Barr Virus Gene Expression Distinguish WHO Type II and III Nasopharyngeal Carcinomas

2007 • 6 citations