Endoplasmic Reticulum Stress Triggers XBP-1–Mediated Up-regulation of an EBV Oncoprotein in Nasopharyngeal Carcinoma

XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

2001 • 3,799 citations

Epstein–Barr virus: 40 years on

2004 • 2,079 citations

ATF6 Activated by Proteolysis Binds in the Presence of NF-Y (CBF) Directly to thecis-Acting Element Responsible for the Mammalian Unfolded Protein Response

2000 • 921 citations

Endoplasmic Reticulum Stress Activates Cleavage of CREBH to Induce a Systemic Inflammatory Response

2006 • 788 citations

The role of the unfolded protein response in tumour development: friend or foe?

2004 • 685 citations

Cellular response to endoplasmic reticulum stress: a matter of life or death

2006 • 659 citations

Clonal Proliferations of Cells Infected with Epstein–Barr Virus in Preinvasive Lesions Related to Nasopharyngeal Carcinoma

1995 • 599 citations

Stress Induction of GRP78/BiP and Its Role in Cancer

2006 • 578 citations

XBP1 Is Essential for Survival under Hypoxic Conditions and Is Required for Tumor Growth

2004 • 537 citations

Epstein--Barr Virus Gene Expression in Nasopharyngeal Carcinoma

1988 • 479 citations

Expression of Epstein‐Barr virus‐encoded proteins in nasopharyngeal carcinoma

1988 • 447 citations

Differential Contributions of ATF6 and XBP1 to the Activation of Endoplasmic Reticulum Stress-Responsive cis-Acting Elements ERSE, UPRE and ERSE-II

2004 • 421 citations

Phosphorylation of the α Subunit of Eukaryotic Initiation Factor 2 Is Required for Activation of NF-κB in Response to Diverse Cellular Stresses

2003 • 410 citations

The Differentiation and Stress Response Factor XBP-1 Drives Multiple Myeloma Pathogenesis

2007 • 397 citations

Tumor Necrosis Factor α (TNFα) Induces the Unfolded Protein Response (UPR) in a Reactive Oxygen Species (ROS)-dependent Fashion, and the UPR Counteracts ROS Accumulation by TNFα

2005 • 370 citations

Critical Role of the Stress Chaperone GRP78/BiP in Tumor Proliferation, Survival, and Tumor Angiogenesis in Transgene-Induced Mammary Tumor Development

2008 • 362 citations

Activation of the p38 Mitogen-activated Protein Kinase Pathway by Epstein-Barr Virus-encoded Latent Membrane Protein 1 Coregulates Interleukin-6 and Interleukin-8 Production

1999 • 347 citations

Modulation of LMP1 protein expression by EBV-encoded microRNAs

2007 • 342 citations

Induction of cyclooxygenase-2 by Epstein–Barr virus latent membrane protein 1 is involved in vascular endothelial growth factor production in nasopharyngeal carcinoma cells

2001 • 260 citations

Epstein-Barr virus latent membrane protein 1 blocks p53-mediated apoptosis through the induction of the A20 gene

1996 • 259 citations

Hepatitis B virus pre‐S mutants, endoplasmic reticulum stress and hepatocarcinogenesis

2006 • 258 citations

Epstein-Barr virus nuclear protein 2 transactivation of the latent membrane protein 1 promoter is mediated by J kappa and PU.1

1995 • 250 citations

Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3β

2004 • 246 citations

The Epstein-Barr virus latent membrane protein 1 induces expression of the epidermal growth factor receptor

1995 • 241 citations

Homocysteine Increases the Expression of Vascular Endothelial Growth Factor by a Mechanism Involving Endoplasmic Reticulum Stress and Transcription Factor ATF4

2004 • 222 citations

Twist and Epithelial-Mesenchymal Transition Are Induced by the EBV Oncoprotein Latent Membrane Protein 1 and Are Associated with Metastatic Nasopharyngeal Carcinoma

2007 • 207 citations

Expression and splicing of the unfolded protein response gene XBP‐1 are significantly associated with clinical outcome of endocrine‐treated breast cancer

2008 • 164 citations

Linkage between STAT Regulation and Epstein-Barr Virus Gene Expression in Tumors

2001 • 156 citations

LMP1 TRAFficking Activates Growth and Survival pathways

2007 • 147 citations

Activation of endoplasmic reticulum stress response by hepatitis viruses up-regulates protein phosphatase 2A

2007 • 133 citations

A New Diagnostic Marker for Secreted Epstein-Barr Virus–Encoded LMP1 and BARF1 Oncoproteins in the Serum and Saliva of Patients with Nasopharyngeal Carcinoma

2007 • 128 citations

X-Box-Binding Protein 1 Activates Lytic Epstein-Barr Virus Gene Expression in Combination with Protein Kinase D

2007 • 127 citations

Plasma Cell-Specific Transcription Factor XBP-1s Binds to and Transactivates the Epstein-Barr Virus BZLF1 Promoter

2007 • 120 citations

Profile of cytokine expression in nasopharyngeal carcinomas: a distinct expression of interleukin 1 in tumor and CD4+ T cells.

1999 • 114 citations

Induction of interleukin-8 by Epstein-Barr virus latent membrane protein-1 and its correlation to angiogenesis in nasopharyngeal carcinoma.

2001 • 107 citations

ER stress is associated with dedifferentiation and an epithelial-to-mesenchymal transition-like phenotype in PC Cl3 thyroid cells

2008 • 106 citations

The LMP1 oncogene of EBV activates PERK and the unfolded protein response to drive its own synthesis

2007 • 106 citations

Requirement for Cell-to-Cell Contact in Epstein-Barr Virus Infection of Nasopharyngeal Carcinoma Cells and Keratinocytes

1999 • 105 citations

The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE-like sequences containing an ACGT core

1996 • 102 citations

Epstein–Barr virus latent membrane protein 1 induces micronucleus formation, represses DNA repair and enhances sensitivity to DNA-damaging agents in human epithelial cells

2004 • 99 citations

Interferon Regulatory Factor 7 Regulates Expression of Epstein-Barr Virus Latent Membrane Protein 1: a Regulatory Circuit

2003 • 97 citations

Epstein-Barr Virus Lytic Transactivator Zta Enhances Chemotactic Activity through Induction of Interleukin-8 in Nasopharyngeal Carcinoma Cells

2008 • 83 citations

Induction of the Early Growth Response 1 Gene by Epstein-Barr Virus Lytic Transactivator Zta

2006 • 65 citations

The Epstein-Barr virus 3.5-kilobase latent membrane protein 1 mRNA initiates from a TATA-Less promoter within the first terminal repeat

1995 • 64 citations

Reconstitution of Nasopharyngeal Carcinoma–Type EBV Infection Induces Tumorigenicity

2008 • 40 citations

Induction of Epstein-Barr Virus Latent Membrane Protein 1 by a Lytic Transactivator Rta

2004 • 40 citations

Up-regulation of a cellular protein at the translational level by a retrovirus

2008 • 17 citations