Molecular and cytogenetic changes involved in the immortalization of nasopharyngeal epithelial cells by telomerase

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

Epstein–Barr virus: 40 years on

2004 • 2,079 citations

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells

1998 • 1,206 citations

Human Keratinocytes That Express hTERT and Also Bypass a p16^INK4a-Enforced Mechanism That Limits Life Span Become Immortal yet Retain Normal Growth and Differentiation Characteristics

2000 • 1,003 citations

Rules for Making Human Tumor Cells

2002 • 928 citations

Selective Inhibition of NF-κB Activation by a Peptide That Blocks the Interaction of NEMO with the IκB Kinase Complex

2000 • 685 citations

Focus on nasopharyngeal carcinoma

2004 • 546 citations

Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene.

1999 • 392 citations

Comparative genomic hybridization using oligonucleotide microarrays and total genomic DNA

2004 • 373 citations

A Two-Stage, p16^INK4A- and p53-Dependent Keratinocyte Senescence Mechanism That Limits Replicative Potential Independent of Telomere Status

2002 • 334 citations

High frequency of promoter hypermethylation of RASSF1A in nasopharyngeal carcinoma.

2001 • 290 citations

NF-κB inhibition causes spontaneous apoptosis in Epstein–Barr virus-transformed lymphoblastoid cells

2000 • 258 citations

High level expression of ΔN-p63: a mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC)?

2000 • 196 citations

Hypermethylation of the p16 gene in nasopharyngeal carcinoma.

1996 • 193 citations

Establishment of two immortalized nasopharyngeal epithelial cell lines using SV40 large T and HPV16E6/E7 viral oncogenes

2002 • 182 citations

Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma.

2003 • 180 citations

Evidence of cisplatin-induced senescent-like growth arrest in nasopharyngeal carcinoma cells.

1998 • 148 citations

Chromosomal aberrations in nasopharyngeal carcinoma analyzed by comparative genomic hybridization

1999 • 110 citations

17q12-21 amplicon, a novel recurrent genetic change in intestinal type of gastric carcinoma: A comparative genomic hybridization study

1997 • 102 citations

RASSF1A is a target tumor suppressor from 3p21.3 in nasopharyngeal carcinoma

2004 • 100 citations

The transcriptional repressor of p16/Ink4a, Id1, is up-regulated in early melanomas.

2001 • 96 citations

The C-terminal Activating Region 2 of the Epstein-Barr Virus-encoded Latent Membrane Protein 1 Activates NF-κB through TRAF6 and TAK1

2005 • 74 citations

Human p14ARF-mediated cell cycle arrest strictly depends on intact p53 signaling pathways

2002 • 71 citations

Alterations of Biologic Properties and Gene Expression in Nasopharyngeal Epithelial Cells by the Epstein-Barr Virus–Encoded Latent Membrane Protein 1

2003 • 70 citations

Cellular signaling pathways engaged by the Epstein-Barr virus transforming protein LMP1

2002 • 59 citations

Distinct profiles of critically short telomeres are a key determinant of different chromosome aberrations in immortalized human cells: whole-genome evidence from multiple cell lines

2004 • 55 citations

Identification of RASSF1A modulated genes in nasopharyngeal carcinoma

2005 • 53 citations

Phenotypic alterations induced by the Hong Kong‐prevalent Epstein‐Barr virus‐encoded LMP1 variant (2117‐LMP1) in nasopharyngeal epithelial cells

2004 • 51 citations

Epstein–Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cells

2004 • 49 citations

MAD2-induced sensitization to vincristine is associated with mitotic arrest and Raf/Bcl-2 phosphorylation in nasopharyngeal carcinoma cells

2003 • 48 citations

RASSF1A, the new guardian of mitosis

2004 • 44 citations

LMP1 of Epstein-Barr Virus Induces Proliferation of Primary Mouse Embryonic Fibroblasts and Cooperatively Transforms the Cells with a p16-Insensitive CDK4 Oncogene

2000 • 38 citations

Evidence of increased Id‐1 expression and its role in cell proliferation in nasopharyngeal carcinoma cells

2002 • 33 citations

Expression of the Helix–Loop–Helix Protein ID1 in Keratinocytes Is Upregulated by Loss of Cell–Matrix Contact

2001 • 17 citations