Stimulation of arachidonic acid release and inhibition of mitogenesis by cloned genes for muscarinic receptor subtypes stably expressed in A9 L cells.

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

1983 • 1,937 citations

Early Signals in the Mitogenic Response

1986 • 1,498 citations

Identification of a Family of Muscarinic Acetylcholine Receptor Genes

1987 • 1,439 citations

Prostaglandins and Thromboxanes

1978 • 1,310 citations

Pirenzepine distinguishes between different subclasses of muscarinic receptors

1980 • 1,299 citations

Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor

1986 • 917 citations

Calcium-mobilizing receptors, polyphosphoinositides, and the generation of second messengers.

1986 • 831 citations

Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes

1988 • 792 citations

Receptor-mediated activation of phospholipase A2 via GTP-binding proteins: arachidonic acid and its metabolites as second messengers

1988 • 512 citations

Primary Structure and Biochemical Properties of an M ₂ Muscarinic Receptor

1987 • 510 citations

Molecular Properties of the Muscarinic Acetylcholine Receptor

1987 • 478 citations

Phospholipase A2 and phospholipase C are activated by distinct GTP-binding proteins in response to alpha 1-adrenergic stimulation in FRTL5 thyroid cells.

1986 • 424 citations

Rapid formation of diacylglycerol from phosphatidylcholine: a pathway for generation of a second messenger.

1986 • 415 citations

An M2 Muscarinic Receptor Subtype Coupled to Both Adenylyl Cyclase and Phosphoinositide Turnover

1987 • 398 citations

Dissociation of bradykinin-induced prostaglandin formation from phosphatidylinositol turnover in Swiss 3T3 fibroblasts: evidence for G protein regulation of phospholipase A2.

1987 • 375 citations

STUDIES ON THE MECHANISM OF ACTION OF A NEW Ca²⁺ ANTAGONIST, 8‐(N,N‐DIETHYLAMINO)OCTYL 3,4,5‐TRIMETHOXYBENZOATE HYDROCHLORIDE IN SMOOTH AND SKELETAL MUSCLES

1975 • 347 citations

Primary structure of porcine cardiac muscarinic acetylcholine receptor deduced from the cDNA sequence

1986 • 344 citations

Stimulation of phospholipase A2 activity in bovine rod outer segments by the beta gamma subunits of transducin and its inhibition by the alpha subunit.

1987 • 344 citations

Receptor-Coupled Activation of Phosphoinositide-Specific Phospholipase C by an N Protein

1986 • 324 citations

Intracellular Ca2+ mobilization by arachidonic acid. Comparison with myo-inositol 1,4,5-trisphosphate in isolated pancreatic islets.

1986 • 310 citations

Phorbol ester inhibits phosphoinositide hydrolysis and calcium mobilization in cultured astrocytoma cells.

1985 • 274 citations

Evidence that Na+/H+ exchange regulates receptor-mediated phospholipase A2 activation in human platelets.

1986 • 196 citations

Long-term phorbol ester treatment down-regulates protein kinase C and sensitizes the phosphoinositide signaling pathway to hormone and growth factor stimulation. Evidence for a role of protein kinase C in agonist-induced desensitization.

1988 • 186 citations

Phorbol esters inhibit agonist-induced [3H] inositol-1-phosphate accumulation in rat hippocampal slices

1984 • 180 citations

Tumor promoter phorbol 12-myristate, 13-acetate inhibits phosphoinositide hydrolysis and cytosolic Ca2+ rise induced by the activation of muscarinic receptors in PC12 cells

1985 • 176 citations

The stimulation of DNA synthesis and cell division in chondrocytes and 3T3 cells by a growth factor isolated from cartilage

1977 • 131 citations

Alpha 1-adrenergic receptor-mediated phosphoinositide hydrolysis and prostaglandin E2 formation in Madin-Darby canine kidney cells. Possible parallel activation of phospholipase C and phospholipase A2.

1987 • 120 citations

The striatum and cerebral cortex express different muscarinic receptor mRNAs

1988 • 90 citations

Alpha 1-adrenergic stimulation of arachidonic acid release and metabolism in a rat thyroid cell line. Mediation of cell replication by prostaglandin E2.

1986 • 89 citations

Evidence for a role in stimulus--secretion coupling of prostaglandins derived from release of arachidonoyl residues as a result of phosphatidylinositol breakdown.

1980 • 59 citations

Phorbol esters and diacylglycerols amplify bradykinin-stimulated prostaglandin synthesis in Swiss 3T3 fibroblasts. Possible independence from protein kinase C.

1988 • 57 citations

Diacylglycerol stimulates phospholipase A₂ from Swiss 3T3 fibroblasts

1988 • 57 citations

Cloned muscarinic receptor subtypes expressed in A9 L cells differ in their coupling to electrical responses.

1988 • 52 citations

Cholinergic stimulation of arachidonic acid and phosphatidic acid metabolism in C62B glioma cells.

1986 • 52 citations

Phospholipase A2 activation in chemotactic peptide-stimulated HL60 granulocytes: Synergism between diacylglycerol and CA2+ in a protein kinase C-independent mechanism

1987 • 48 citations

Expression of a cloned muscarinic receptor in A9 L cells.

1987 • 43 citations

Cholinergic and α-Adrenergic Stimulation of Prostaglandin Release by Dog Thyroid in Vitro*

1979 • 41 citations

Acetylcholine dramatically increases prostanoid synthesis in piglet parietal cortex

1988 • 40 citations

Electrophysiological characterization of cloned m1 muscarinic receptors expressed in A9 L cells.

1988 • 39 citations

Acetylcholine induces vasodilation and prostacyclin synthesis in rat lungs

1986 • 25 citations