Insulin regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase‐dependent pathway

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

1989 • 1,237 citations

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

1997 • 991 citations

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

1998 • 969 citations

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

1994 • 923 citations

Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing

1990 • 895 citations

Phosphoinositides as Regulators in Membrane Traffic

1996 • 717 citations

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1996 • 713 citations

The IRS-signalling system: A network of docking proteins that mediate insulin action

1998 • 693 citations

Untitled

1998 • 523 citations

Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6

1991 • 442 citations

Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative.

1994 • 373 citations

Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin

1994 • 362 citations

RETRACTED: Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease

1997 • 345 citations

Insulin-like growth factor I protects and rescues hippocampal neurons against β-amyloid- and human amylin-induced toxicity

1997 • 325 citations

Alzheimer's disease – synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts

1998 • 292 citations

Structure, expression, and regulation of protein kinases involved in the phosphorylation of ribosomal protein S6.

1991 • 265 citations

Molecular mechanisms for the control of translation by insulin

1997 • 257 citations

Altered cerebral energy metabolism in Alzheimer's disease: a PET study.

1994 • 229 citations

Regulation of Amyloid Precursor Protein Cleavage

1999 • 224 citations

Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors.

1986 • 218 citations

Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells

1991 • 210 citations

Reduced platelet cytochrome c oxidase activity in Alzheimer's disease

1994 • 199 citations

Predominant abnormality in cerebral glucose utilization in late-onset dementia of the Alzheimer type: A cross-sectional comparison against advanced late-onset and incipient early-onset cases

1991 • 193 citations

Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner.

1994 • 181 citations

Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease

1998 • 167 citations

Regulation of Amyloid Precursor Protein Catabolism Involves the Mitogen-Activated Protein Kinase Signal Transduction Pathway

1997 • 133 citations

Alzheimer's Amyloid Precursor Protein α-Secretase Is Inhibited by Hydroxamic Acid-Based Zinc Metalloprotease Inhibitors: Similarities to the Angiotensin Converting Enzyme Secretase

1998 • 122 citations

Mitogen‐Activated Protein Kinase‐Dependent and Protein Kinase C‐Dependent Pathways Link the m1 Muscarinic Receptor to β‐Amyloid Precursor Protein Secretion

1998 • 122 citations

Altered metabolic properties of cultured skin fibroblasts in Alzheimer's disease

1987 • 121 citations

Evidence for Physiological Down-regulation of Brain Oxidative Phosphorylation in Alzheimer's Disease

1996 • 116 citations

Tacrine alters the secretion of the beta‐amyloid precursor protein in cell lines

1994 • 111 citations

Regulation of Secretion of Alzheimer Amyloid Precursor Protein by the Mitogen‐Activated Protein Kinase Cascade

1998 • 109 citations

Activation of translation initiation factor eIF2B by insulin requires phosphatidyl inositol 3‐kinase

1997 • 101 citations

Oxidative metabolism deficiencies in brains of patients with Alzheimer's disease

1996 • 93 citations

Effect of energy shortage and oxidative stress on amyloid precursor protein metabolism in COS cells

1997 • 89 citations

Oxidative metabolism in cultured fibroblasts derived from sporadic Alzheimer's disease (AD) patients

1997 • 79 citations

Toxic effect of a β-amyloid peptide (β22–35) on the hippocampal neuron and its prevention

1993 • 77 citations

Protein Kinase C Activation Increases Release of Secreted Amyloid Precursor Protein without Decreasing Aβ Production in Human Primary Neuron Cultures.

1998 • 73 citations

Defective phorbol ester-stimulated secretion of β-amyloid precursor protein from Alzheimer's disease fibroblasts

1995 • 63 citations

Rapid stimulation of amyloid precursor protein release by epidermal growth factor: role of protein kinase C

1997 • 60 citations

Rationalizing a pharmacological intervention on the amyloid precursor protein metabolism

1999 • 51 citations

Phosphatidylinositol 3′-kinase, But Not p70 Ribosomal S6 Kinase, Is Involved in Membrane Protein Recycling: Wortmannin Inhibits Glucose Transport and Downregulates Cell-Surface Transferrin Receptor Numbers Independently of Any Effect on Fluid-phase Endocytosis in Fibroblasts

1996 • 40 citations

Inherent Abnormalities in Oxidative Metabolism in Alzheimer's Disease: Interaction with Vascular Abnormalities

1997 • 29 citations

Energy metabolism inhibition impairs amyloid precursor protein secretion from Alzheimer's fibroblasts

1999 • 27 citations

Bradykinin-induced amyloid precursor protein secretion: a protein kinase C-independent mechanism that is not altered in fibroblasts from patients with sporadic Alzheimer's disease

1998 • 24 citations