Simultaneous determination of tyrosine, phenylalanine and deoxyguanosine oxidation products by liquid chromatography–tandem mass spectrometry as non-invasive biomarkers for oxidative damage

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer

1996 • 2,327 citations

Lipid peroxidation and protein oxidation in Alzheimer’s disease brain: potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress 1,2 1Guest Editors: Mark A. Smith and George Perry 2This article is part of a series of reviews on “Causes and Consequences of Oxidative Stress in Alzheimer’s Disease.” The full list of papers may be found on the homepage of the journal.

2002 • 961 citations

Biomarkers of free radical damage

1999 • 843 citations

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro

1995 • 741 citations

Invited Review Free Radicals in Disease Processes: A Compilation of Cause and Consequence

1993 • 581 citations

Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes.

1996 • 560 citations

Electrochemical Analysis of Protein Nitrotyrosine and Dityrosine in the Alzheimer Brain Indicates Region-Specific Accumulation

1998 • 507 citations

Reactive Nitrogen Intermediates Promote Low Density Lipoprotein Oxidation in Human Atherosclerotic Intima

1997 • 470 citations

Mass Spectrometric Quantification of Markers for Protein Oxidation by Tyrosyl Radical, Copper, and Hydroxyl Radical in Low Density Lipoprotein Isolated from Human Atherosclerotic Plaques

1997 • 355 citations

[40] Preparation and characterization of chloramines

1986 • 345 citations

The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer’s and Parkinson’s diseases1,2 11Guest Editors: Mark A. Smith and George Perry 22This article is part of a series of reviews on “Causes and Consequences of Oxidative Stress in Alzheimer’s Disease.” The full list of papers may be found on the homepage of the journal.

2002 • 277 citations

Human neutrophils employ chlorine gas as an oxidant during phagocytosis.

1996 • 258 citations

Biomarkers

2002 • 248 citations

Quantification of 8-oxo-guanine and guanine as the nucleobase, nucleoside and deoxynucleoside forms in human urine by high-performance liquid chromatography-electrospray tandem mass spectrometry

2002 • 247 citations

8‐hydroxydeoxyguanosine as a urinary biomarker of oxidative DNA damage

1993 • 225 citations

Formation of o-tyrosine and dityrosine in proteins during radiolytic and metal-catalyzed oxidation

1993 • 222 citations

Diseases related to oxygen-derived free radicals.

1995 • 215 citations

Chronic antioxidant treatment improves the cognitive performance of aged rats

1995 • 186 citations

Dityrosine: Preparation, Isolation, and Analysis

1996 • 183 citations

Oxidants, antioxidant nutrients and the athlete

1997 • 179 citations

Reduction of oxidative DNA-damage in humans by Brussels sprouts

1995 • 174 citations

Determination of urinary 8-hydroxydeoxyguanosine by automated coupled-column high performance liquid chromatography: a powerful technique for assaying in vivo oxidative DNA damage in cancer patients

1995 • 163 citations

Characterization of free radical-induced base damage in DNA at biologically relevant levels

1986 • 160 citations

A hydroxyl radical–like species oxidizes cynomolgus monkey artery wall proteins in early diabetic vascular disease

2001 • 153 citations

Thioredoxin as a biomarker for oxidative stress in patients with rheumatoid arthritis

2002 • 153 citations

Mercapturic Acids, Protein Adducts, and DNA Adducts as Biomarkers of Electrophilic Chemicals

1992 • 150 citations

The Use of Biological Markers in Toxicology

1989 • 147 citations

Human Phagocytes Employ the Myeloperoxidase-Hydrogen Peroxide System to Synthesize Dityrosine, Trityrosine, Pulcherosine, and Isodityrosine by a Tyrosyl Radical-dependent Pathway

1996 • 147 citations

Raised levels of F2-isoprostanes and prostaglandin F2alpha in different rheumatic diseases

2001 • 136 citations

Artifact-Free Quantification of Free 3-Chlorotyrosine, 3-Bromotyrosine, and 3-Nitrotyrosine in Human Plasma by Electron Capture–Negative Chemical Ionization Gas Chromatography Mass Spectrometry and Liquid Chromatography–Electrospray Ionization Tandem Mass Spectrometry

2002 • 133 citations

Monitoring of oxidative free radical damage in vivo: Analytical aspects

1992 • 114 citations

Increased oxidative stress in kwashiorkor

2000 • 96 citations

Detecting oxidative modification of biomolecules with isotope dilution mass spectrometry: Sensitive and quantitative assays for oxidized amino acids in proteins and tissues

1999 • 95 citations

Supplementation with antioxidant vitamins prevents oxidative modification of DNA in lymphocytes of HIV-infected patients

2002 • 94 citations

Progress in the analysis of urinary oxidative DNA damage

2002 • 93 citations

Fast quantification of the urinary marker of oxidative stress 8-hydroxy-2′-deoxyguanosine using solid-phase extraction and high-performance liquid chromatography with triple-stage quadrupole mass detection

2000 • 87 citations

Isotope Dilution Mass Spectrometric Quantification of 3-Nitrotyrosine in Proteins and Tissues Is Facilitated by Reduction to 3-Aminotyrosine

1998 • 87 citations

Analysis of amino acids by gas chromatography—flame ionization detection and gas chromatography—mass spectrometry: Simultaneous derivatization of functional groups by an aqueous-phase chloroformate-mediated reaction

1994 • 77 citations

GABP Mediates Insulin-increased Prolactin Gene Transcription

1996 • 68 citations

Measurement of 3-Nitrotyrosine and 5-Nitro-γ-Tocopherol by high-performance liquid chromatography with electrochemical detection

2000 • 65 citations

Effect of Drinking Green Tea on Age-Associated Accumulation of Maillard-Type Fluorescence and Carbonyl Groups in Rat Aortic and Skin Collagen

2002 • 59 citations

Design, Synthesis, and Characterization of 7-Methoxy-4-(aminomethyl)coumarin as a Novel and Selective Cytochrome P450 2D6 Substrate Suitable for High-Throughput Screening

1999 • 57 citations

Simultaneous determination of eight lipid peroxidation degradation products in urine of rats treated with carbon tetrachloride using gas chromatography with electron-capture detection

1997 • 55 citations

Vitamin E and probucol reduce urinary lipophilic aldehydes and renal enlargement in streptozotocin‐induced diabetic rats

2000 • 48 citations

Quantification ofo,o‘-Dityrosine,o-Nitrotyrosine, ando-Tyrosine in Cat Urine Samples by LC/Electrospray Ionization-MS/MS Using Isotope Dilution

2002 • 47 citations

Proteinl-Dopa as an Index of Hydroxyl Radical Attack on Protein Tyrosine

1998 • 44 citations

Modulation of the sarcolemmal L-type current by alteration in SR Ca²⁺release

1999 • 39 citations

Evaluation of Urinary Biomarkers for Radical-Induced Liver Damage in Rats Treated with Carbon Tetrachloride

1998 • 34 citations

Urinary excretion of biomarkers for radical-induced damage in rats treated with NDMA or diquat and the effects of calcium carbimide co-administration

1999 • 31 citations

Interpretation of Diagnostic Tests. A Handbook Synopsis of Laboratory Medicine.

1971 • 28 citations

Urinary Excretion of Biomarkers of Oxidative Kidney Damage Induced by Ferric Nitrilotriacetate,

1998 • 26 citations

Simultaneous determination of eight lipid peroxidation degradation products in urine of rats treated with carbon tetrachloride using gas chromatography with electron-capture detection.

1997 • 20 citations