A single WW domain is the predominant mediator of the interaction between the human ubiquitin-protein ligase Nedd4 and the human epithelial sodium channel

A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

1995 • 12,826 citations

SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modeling

1997 • 10,943 citations

Calculation of protein extinction coefficients from amino acid sequence data

1989 • 5,198 citations

Liddle's syndrome: Heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channel

1994 • 1,238 citations

The importance of being proline: the interaction of proline‐rich motifs in signaling proteins with their cognate domains

2000 • 1,198 citations

Epithelial sodium channels: function, structure, and regulation

1997 • 1,154 citations

ProMod and Swiss-Model: Internet-based tools for automated comparative protein modelling

1996 • 948 citations

Real-time biospecific interaction analysis using surface plasmon resonance and a sensor chip technology.

1991 • 909 citations

WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.

1996 • 828 citations

Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1

1996 • 794 citations

Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination

1997 • 696 citations

Molecular Genetics of Human Blood Pressure Variation

1996 • 637 citations

Structure of the WW domain of a kinase-associated protein complexed with a proline-rich peptide

1996 • 426 citations

Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na+ channel

1995 • 408 citations

Generalized Born Model Based on a Surface Integral Formulation

1998 • 378 citations

Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome

1999 • 358 citations

Exploiting the Basis of Proline Recognition by SH3 and WW Domains: Design of N-Substituted Inhibitors

1998 • 309 citations

A mutation in the epithelial sodium channel causing Liddle disease increases channel activity in the Xenopus laevis oocyte expression system.

1995 • 304 citations

Crystal Structures of a Schistosomal Drug and Vaccine Target: Glutathione S-Transferase fromSchistosoma japonicaand its Complex with the Leading Antischistomal Drug Praziquantel

1995 • 301 citations

A novel mouse Nedd4 protein suppresses the activity of the epithelial Na⁺channel

2001 • 290 citations

Structure of a WW domain containing fragment of dystrophin in complex with beta-dystroglycan.

2000 • 255 citations

SH2- and SH3-mediated Interactions between Focal Adhesion Kinase and Src

1998 • 249 citations

Role of gammaENaC subunit in lung liquid clearance and electrolyte balance in newborn mice. Insights into perinatal adaptation and pseudohypoaldosteronism.

1998 • 247 citations

Disruption of the β subunit of the epithelial Na ⁺ channel in mice: Hyperkalemia and neonatal death associated with a pseudohypoaldosteronism phenotype

1999 • 243 citations

Structural analysis of WW domains and design of a WW prototype.

2000 • 221 citations

Solution structure of a Nedd4 WW domain-ENaC peptide complex.

2001 • 221 citations

Inhibition of the Epithelial Na+ Channel by Interaction of Nedd4 with a PY Motif Deleted in Liddle's Syndrome

1998 • 178 citations

Distinct characteristics of two human Nedd4 proteins with respect to epithelial Na⁺channel regulation

2001 • 127 citations

All Three WW Domains of Murine Nedd4 Are Involved in the Regulation of Epithelial Sodium Channels by Intracellular Na+

1999 • 123 citations

Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4

2000 • 106 citations

The Dimerization Property of Glutathione -Transferase Partially Reactivates Bcr-Abl Lacking the Oligomerization Domain

1996 • 89 citations

Multiple WW Domains, but Not the C2 Domain, Are Required for Inhibition of the Epithelial Na+ Channel by Human Nedd4

2001 • 84 citations

Characterization of the β-Dystroglycan–Growth Factor Receptor 2 (Grb2) Interaction

2000 • 83 citations

Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits

2000 • 54 citations

A biosensor approach to probe the structure and function of the p85 alpha subunit of the phosphatidylinositol 3-kinase complex

1993 • 52 citations

Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits

2000 • 34 citations

Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4

2000 • 31 citations

Characterization of Interactions between Nedd4 and β and γENaC Using Surface Plasmon Resonance

2001 • 28 citations