Characterization of Interactions between Nedd4 and β and γENaC Using Surface Plasmon Resonance

The Kidney: Physiology and Pathophysiology

1992 • 1,714 citations

Epithelial sodium channels: function, structure, and regulation

1997 • 1,154 citations

Kinetic analysis of monoclonal antibody-antigen interactions with a new biosensor based analytical system

1991 • 1,071 citations

WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.

1996 • 828 citations

Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination

1997 • 696 citations

Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na+ channel

1995 • 408 citations

Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome.

1996 • 397 citations

Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome

1999 • 358 citations

A mutation in the epithelial sodium channel causing Liddle disease increases channel activity in the Xenopus laevis oocyte expression system.

1995 • 304 citations

Solution structure of a Nedd4 WW domain-ENaC peptide complex.

2001 • 221 citations

Epithelial Na+ Channels

1991 • 188 citations

Inhibition of the Epithelial Na+ Channel by Interaction of Nedd4 with a PY Motif Deleted in Liddle's Syndrome

1998 • 178 citations

Mutations causing Liddle syndrome reduce sodium-dependent downregulation of the epithelial sodium channel in the Xenopus oocyte expression system.

1998 • 161 citations

All Three WW Domains of Murine Nedd4 Are Involved in the Regulation of Epithelial Sodium Channels by Intracellular Na+

1999 • 123 citations

Multiple WW Domains, but Not the C2 Domain, Are Required for Inhibition of the Epithelial Na+ Channel by Human Nedd4

2001 • 84 citations

Amiloride-sensitive Na channels

1998 • 82 citations

Feedback inhibition of rat amiloride‐sensitive epithelial sodium channels expressed in Xenopus laevis oocytes

1999 • 71 citations

Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits

2000 • 54 citations

In vitro phosphorylation of COOH termini of the epithelial Na⁺channel and its effects on channel activity inXenopusoocytes

2001 • 34 citations