Roles of Gβγ in membrane recruitment and activation of p110γ/p101 phosphoinositide 3-kinase γ

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

The Phosphoinositide 3-Kinase Pathway

2002 • 5,427 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Synthesis and Function of 3-Phosphorylated Inositol Lipids

2001 • 1,527 citations

PHOSPHOINOSITIDE KINASES

1998 • 1,321 citations

Cellular Function of Phosphoinositide 3-Kinases: Implications for Development, Immunity, Homeostasis, and Cancer

2001 • 1,153 citations

Substitution of three amino acids switches receptor specificity of Gqα to that of Giα

1993 • 702 citations

Cloning and Characterization of a G Protein-Activated Human Phosphoinositide-3 Kinase

1995 • 673 citations

Linkage of G Protein-Coupled Receptors to the MAPK Signaling Pathway Through PI 3-Kinase γ

1997 • 671 citations

A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits

1994 • 597 citations

Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ

2000 • 596 citations

The Gβγ Sensitivity of a PI3K Is Dependent upon a Tightly Associated Adaptor, p101

1997 • 549 citations

Regulation of the p85/p110 Phosphatidylinositol 3′-Kinase: Stabilization and Inhibition of the p110α Catalytic Subunit by the p85 Regulatory Subunit

1998 • 508 citations

The role of phosphoinositides in membrane transport

2001 • 482 citations

Structural insights into phosphoinositide 3-kinase catalysis and signalling

1999 • 478 citations

Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate

1993 • 449 citations

Membrane Localization of Phosphatidylinositol 3-Kinase Is Sufficient To Activate Multiple Signal-Transducing Kinase Pathways

1996 • 443 citations

Activation of Akt/Protein Kinase B by G Protein-coupled Receptors

1998 • 333 citations

The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors

1990 • 323 citations

Bifurcation of Lipid and Protein Kinase Signals of PI3Kγ to the Protein Kinases PKB and MAPK

1998 • 310 citations

Phosphatidylinositol 3-Kinase-dependent Membrane Association of the Bruton's Tyrosine Kinase Pleckstrin Homology Domain Visualized in Single Living Cells

1999 • 291 citations

Molecular Balance between the Regulatory and Catalytic Subunits of Phosphoinositide 3-Kinase Regulates Cell Signaling and Survival

2002 • 284 citations

Structural Basis of 3-Phosphoinositide Recognition by Pleckstrin Homology Domains

2000 • 270 citations

Heterodimeric Phosphoinositide 3-Kinase Consisting of p85 and p110β Is Synergistically Activated by the βγ Subunits of G Proteins and Phosphotyrosyl Peptide

1997 • 261 citations

Signaling and Subcellular Targeting by Membrane-Binding Domains

2000 • 259 citations

Translocation and Reversible Localization of Signaling Proteins

2000 • 228 citations

Roles of Non-catalytic Subunits in Gβγ-induced Activation of Class I Phosphoinositide 3-Kinase Isoforms β and γ

1999 • 220 citations

The pleckstrin homology domains of protein kinase B and GRP1 (general receptor for phosphoinositides-1) are sensitive and selective probes for the cellular detection of phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 3,4,5-trisphosphate in vivo

1999 • 192 citations

Gβγ Stimulates Phosphoinositide 3-Kinase-γ by Direct Interaction with Two Domains of the Catalytic p110 Subunit

1998 • 191 citations

A G Protein γ Subunit Shares Homology with ras Proteins

1989 • 153 citations

Phoxy Lipids

2001 • 145 citations

How accurately can we image inositol lipids in living cells?

2000 • 145 citations

β‐Subunits of the human liver G_s/G_i signal‐transducing proteins and those of bovine retinal rod cell transducin are identical

1986 • 119 citations

G Proteins endogenously expressed in Sf 9 cells: interactions with mammalian histamine receptors

1997 • 95 citations

Phosphoinositide 3-Kinase γ Is a Mediator of Gβγ-dependent Jun Kinase Activation

1998 • 90 citations

Characterizing the Interactions between the Two Subunits of the p101/p110γ Phosphoinositide 3-Kinase and Their Role in the Activation of This Enzyme by Gβγ Subunits

1999 • 86 citations

Purification and Characterization of Gβγ-responsive Phosphoinositide 3-Kinases from Pig Platelet Cytosol

1997 • 84 citations

Stimulation of Human Neutrophils by Chemotactic Factors Is Associated with the Activation of Phosphatidylinositol 3-Kinase γ

2000 • 76 citations

Diffusion‐limited translocation mechanism of protein kinase C isotypes

2001 • 75 citations

Gβ5γ2 Is a Highly Selective Activator of Phospholipid-dependent Enzymes

2000 • 74 citations

Agonists Cause Nuclear Translocation of Phosphatidylinositol 3-Kinase γ

1999 • 64 citations

Intracellular Movement of Green Fluorescent Protein–Tagged Phosphatidylinositol 3-Kinase in Response to Growth Factor Receptor Signaling

1999 • 62 citations

Recruitment of pleckstrin and phosphoinositide 3-kinase gamma into the cell membranes, and their association with G beta gamma after activation of NK cells with chemokines.

1999 • 58 citations

Recruitment of Pleckstrin and Phosphoinositide 3-Kinase γ into the Cell Membranes, and Their Association with Gβγ After Activation of NK Cells with Chemokines

1999 • 46 citations

Mechanism of the regulation of type IB phosphoinositide 3OH-kinase byG-protein βγ subunits

2002 • 33 citations

Gβγ Mediate Differentiation of Vascular Smooth Muscle Cells

2001 • 29 citations

Retinoic acid induces selective expression of phosphoinositide 3-kinase gamma in myelomonocytic U937 cells.

1999 • 27 citations

Mechanism of the regulation of type IB phosphoinositide 3OH-kinase byG-protein βγ subunits

2002 • 19 citations

Anionic Phospholipids Are Involved in Membrane Targeting of PI 3-Kinase γ

2001 • 18 citations

Regulation of phosphoinositide 3-kinaseγ protein kinase activityin vitro and in COS-7 cells

2001 • 6 citations