The oncogenic properties of mutant p110α and p110β phosphatidylinositol 3-kinases in human mammary epithelial cells

Mutations of the BRAF gene in human cancer

2002 • 10,249 citations

The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

2002 • 5,914 citations

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

High Frequency of Mutations of the PIK3CA Gene in Human Cancers

2004 • 3,304 citations

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1997 • 2,746 citations

Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF

2004 • 2,674 citations

PHOSPHOINOSITIDE KINASES

1998 • 1,321 citations

Mutation of the PIK3CA Gene in Ovarian and Breast Cancer

2004 • 898 citations

The Biology and Clinical Relevance of the PTEN Tumor Suppressor Pathway

2004 • 889 citations

Mutant PIK3CA promotes cell growth and invasion of human cancer cells

2005 • 873 citations

Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells

2001 • 854 citations

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

1995 • 831 citations

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

2005 • 813 citations

The PIK3CA gene is mutated with high frequency in human breast cancers

2004 • 654 citations

Enumeration of the Simian Virus 40 Early Region Elements Necessary for Human Cell Transformation

2002 • 604 citations

Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes

2001 • 552 citations

Regulation of the p85/p110 Phosphatidylinositol 3′-Kinase: Stabilization and Inhibition of the p110α Catalytic Subunit by the p85 Regulatory Subunit

1998 • 508 citations

Cellular transformation by SV40 large T antigen: interaction with host proteins

2001 • 361 citations

Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding.

1992 • 344 citations

Mutations of PIK3CA in Anaplastic Oligodendrogliomas, High-Grade Astrocytomas, and Medulloblastomas

2004 • 340 citations

Overexpression and overactivation of Akt in thyroid carcinoma.

2001 • 296 citations

Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase

2003 • 277 citations

Inactivation of p16 in Human Mammary Epithelial Cells by CpG Island Methylation

1998 • 231 citations

Critical Role for SV40 Small-t Antigen in Human Cell Transformation

2001 • 131 citations

Identification of a Minimal Transforming Domain of p53: Negative Dominance through Abrogation of Sequence-Specific DNA Binding

1992 • 113 citations

Mechanism of Constitutive Phosphoinositide 3-Kinase Activation by Oncogenic Mutants of the p85 Regulatory Subunit

2005 • 84 citations

Functional genetics and experimental models of human cancer

2004 • 63 citations

β1-Integrin and PTEN control the phosphorylation of protein kinase C

2000 • 43 citations