Divergence in Signal Transduction Pathways of Platelet-derived Growth Factor (PDGF) and Epidermal Growth Factor (EGF) Receptors

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Protein modules and signalling networks

1995 • 2,447 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

Growth Factors and Cancer

1991 • 2,044 citations

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1992 • 1,358 citations

Signal transduction via the MAP kinases: proceed at your own RSK.

1993 • 1,262 citations

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1992 • 998 citations

[36] Eukaryotic gene transcription with purified components

1983 • 992 citations

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

1989 • 933 citations

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1993 • 879 citations

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1994 • 728 citations

Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

1993 • 658 citations

Signal Transduction by the Platelet-Derived Growth Factor Receptor

1989 • 653 citations

Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation.

1991 • 627 citations

Platelet-derived growth factor receptor signals.

1994 • 561 citations

The GTPase dynamin binds to and is activated by a subset of SH3 domains

1993 • 557 citations

Serine Palmitoyltransferase Is the Primary Target of a Sphingosine-like Immunosuppressant, ISP-1/Myriocin

1995 • 537 citations

Substrates for p34cdc2: In vivo veritas?

1990 • 472 citations

SH2/SH3 signaling proteins

1994 • 457 citations

Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets

1995 • 435 citations

How receptor tyrosine kinases activate ras

1993 • 393 citations

Calcium mobilization via sphingosine kinase in signalling by the FcɛRI antigen receptor

1996 • 374 citations

Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor.

1996 • 280 citations

Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway.

1994 • 273 citations

Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction.

1995 • 264 citations

Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium.

1994 • 253 citations

Differential Inhibition of Signaling Pathways by Dominant-Negative SH2/SH3 Adapter Proteins

1995 • 233 citations

CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle.

1992 • 230 citations

GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit.

1992 • 228 citations

Sphingolipid metabolites: Members of a new class of lipid second messengers

1995 • 226 citations

Differential Regulation of Sphingomyelinase and Ceramidase Activities by Growth Factors and Cytokines

1995 • 222 citations

Activation of a High Affinity Gi Protein-coupled Plasma Membrane Receptor by Sphingosine-1-phosphate

1996 • 197 citations

Inhibition of sphingosine kinase in vitro and in platelets. Implications for signal transduction pathways.

1992 • 193 citations

Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts.

1994 • 188 citations

CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells.

1994 • 182 citations

Sphingosine 1-Phosphate Rapidly Activates the Mitogen-activated Protein Kinase Pathway by a G Protein-dependent Mechanism

1995 • 180 citations

Cell Cycle Arrest Induced by an Inhibitor of Glucosylceramide Synthase

1995 • 165 citations

v-Crk Modulation of Growth Factor-induced PC12 Cell Differentiation Involves the Src Homology 2 Domain of v-Crk and Sustained Activation of the Ras/Mitogen-activated Protein Kinase Pathway

1995 • 151 citations

The product of the cellular crk gene consists primarily of SH2 and SH3 regions.

1992 • 147 citations

Direct demonstration of an intramolecular SH2—phosphotyrosine interaction in the Crk protein

1995 • 130 citations

Sphingomyelin‐Derived Lipids Differentially Regulate the Extracellular Signal‐Regulated Kinase 2 (ERK‐2) and c‐Jun N‐Terminal Kinase (JNK) Signal Cascades in Airway Smooth Muscle

1996 • 126 citations

Insulin-like Growth Factor-I Stimulates Tyrosine Phosphorylation of Endogenous c-Crk

1995 • 112 citations

Both the SH2 and SH3 domains of human CRK protein are required for neuronal differentiation of PC12 cells.

1993 • 100 citations

Sphingosine 1-phosphate, a novel signaling molecule, stimulates DNA binding activity of AP-1 in quiescent Swiss 3T3 fibroblasts.

1994 • 86 citations

The Proto-oncogene Product c-Crk Associates with Insulin Receptor Substrate-1 and 4PS

1996 • 84 citations

Expression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- and epidermal growth factor-dependent pathways.

1994 • 79 citations

Stereospecificity of sphingosine-induced intracellular calcium mobilization and cellular proliferation.

1994 • 76 citations

Crk Interacts with Tyrosine-phosphorylated p116 upon T Cell Activation

1995 • 72 citations

Sphingosine Kinase in Blood Platelets

1973 • 66 citations

Platelet-derived growth factor activates membrane-associated phosphatidylinositol 3-kinase and mediates its translocation from the cytosol. Detection of enzyme activity in detergent-solubilized cell extracts

1992 • 64 citations

Mitogenesis of 3T3 fibroblasts induced by endogenous ganglioside is not mediated by cAMP, protein kinase C, or phosphoinositides turnover

1988 • 59 citations

Properties and Specificities of Sphingosine Kinase from Blood Platelets

1973 • 58 citations

Sphingolipids as mediators of effects of platelet-derived growth factor in vascular smooth muscle cells

1993 • 51 citations

Biological function of PDGF-induced PI-3 kinase activity: its role in alpha PDGF receptor-mediated mitogenic signaling.

1994 • 37 citations