FLAP: a novel drug target for inhibiting the synthesis of leukotrienes

Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis

1990 • 777 citations

Identification and isolation of a membrane protein necessary for leukotriene production

1990 • 464 citations

L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor

1989 • 337 citations

Translocation of 5-lipoxygenase to the membrane in human leukocytes challenged with ionophore A23187.

1988 • 323 citations

Formation and actions of leukotrienes

1984 • 320 citations

MK886, a potent and specific leukotriene biosynthesis inhibitor blocks and reverses the membrane association of 5-lipoxygenase in ionophore-challenged leukocytes.

1990 • 319 citations

Leukotriene B4 in inflammation.

1990 • 294 citations

Correlation between expression of 5-lipoxygenase-activating protein, 5-lipoxygenase, and cellular leukotriene synthesis.

1990 • 191 citations

The Long-term Effects of Nedocromil Sodium and Beclomethasone Dipropionate on Bronchial Responsiveness to Methacholine in Nonatopic Asthmatic Subjects

1990 • 177 citations

The pharmacology of L-670,596, a potent and selective thromboxane/prostaglandin endoperoxide receptor antagonist

1989 • 39 citations

Leukotrienes and lipoxygenases; chemical, biological and clinical aspects

1991 • 4 citations