Long-term potentiation and long-term depression in the neocortex

The organization of behavior

1988 • 8,668 citations

Handbook of Sensory Physiology

1975 • 7,212 citations

LOSS OF RECENT MEMORY AFTER BILATERAL HIPPOCAMPAL LESIONS

1957 • 7,145 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

The organization of behavior.

1950 • 6,879 citations

Magnesium gates glutamate-activated channels in mouse central neurones

1984 • 3,999 citations

The period of susceptibility to the physiological effects of unilateral eye closure in kittens

1970 • 2,965 citations

Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex

1982 • 2,824 citations

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

1988 • 2,572 citations

SINGLE-CELL RESPONSES IN STRIATE CORTEX OF KITTENS DEPRIVED OF VISION IN ONE EYE

1963 • 2,565 citations

Excitatory amino acids in synaptic transmission in the Schaffer collateral‐commissural pathway of the rat hippocampus.

1983 • 2,376 citations

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

1986 • 1,842 citations

The physiology of excitatory amino acids in the vertebrate central nervous system

1987 • 1,718 citations

Inhibition of Postsynaptic PKC or CaMKII Blocks Induction But Not Expression of LTP

1989 • 1,335 citations

Mechanisms of Memory

1986 • 1,252 citations

Long-Term Depression

1989 • 1,151 citations

A memory system in the monkey

1982 • 1,137 citations

The Neurobiology of Learning and Memory

1986 • 1,124 citations

A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory.

1989 • 1,114 citations

Intracellular injections of EGTA block induction of hippocampal long-term potentiation

1983 • 1,106 citations

The Biochemistry of Memory: A New and Specific Hypothesis

1984 • 1,048 citations

An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation

1989 • 1,015 citations

Postnatal development of the visual cortex and the influence of environment

1982 • 960 citations

Long-term potentiation and NMDA receptors in rat visual cortex

1987 • 953 citations

Climbing fibre induced depression of both mossy fibre responsiveness and glutamate sensitivity of cerebellar Purkinje cells

1982 • 940 citations

Blockade of "NMDA" Receptors Disrupts Experience-Dependent Plasticity of Kitten Striate Cortex

1987 • 920 citations

Different voltage-dependent thresholds for inducing long-term depression and long-term potentiation in slices of rat visual cortex

1990 • 893 citations

Regulation of brain Type II Ca2+/calmodulin-dependent protein kinase by autophosphorylation: A Ca2+-triggered molecular switch

1986 • 856 citations

Postsynaptic Calcium Is Sufficient for Potentiation of Hippocampal Synaptic Transmission

1988 • 830 citations

Long-Term Potentiation

1987 • 804 citations

Presynaptic enhancement shown by whole-cell recordings of long-term potentiation in hippocampal slices

1990 • 803 citations

Temporal contiguity requirements for long-term associative potentiation/depression in the hippocampus

1983 • 773 citations

Neuronal correlate of visual associative long-term memory in the primate temporal cortex

1988 • 763 citations

A new type of glutamate receptor linked to inositol phospholipid metabolism

1987 • 743 citations

Organization of visual pathways in normal and visually deprived cats.

1982 • 725 citations

A Physiological Mechanism for Hebb's Postulate of Learning

1973 • 711 citations

Presynaptic mechanism for long-term potentiation in the hippocampus

1990 • 691 citations

THE MEMBRANE SKELETON OF HUMAN ERYTHROCYTES AND ITS IMPLICATIONS FOR MORE COMPLEX CELLS

1985 • 673 citations

The NO hypothesis: possible effects of a short-lived, rapidly diffusible signal in the development and function of the nervous system.

1990 • 653 citations

Potentiation of synaptic transmission in the hippocampus by phorbol esters

1986 • 647 citations

Mechanisms Underlying Long-Term Potentiation of Synaptic Transmission

1991 • 615 citations

Arachidonic acid induces a long-term activity-dependent enhancement of synaptic transmission in the hippocampus

1989 • 612 citations

Heterosynaptic depression: a postsynaptic correlate of long-term potentiation

1977 • 606 citations

Synapses as associative memory elements in the hippocampal formation

1979 • 573 citations

Storing covariance with nonlinearly interacting neurons

1977 • 558 citations

Hebbian Synapses: Biophysical Mechanisms and Algorithms

1990 • 551 citations

Neurobiology of Neocortex

1989 • 540 citations

The current excitement in long term potentiation

1988 • 538 citations

A Physiological Basis for a Theory of Synapse Modification

1987 • 535 citations

Disruption of experience-dependent synaptic modifications in striate cortex by infusion of an NMDA receptor antagonist

1990 • 497 citations

Specific long-lasting potentiation of synaptic transmission in hippocampal slices

1977 • 493 citations

Excitatory Amino Acid Neurotransmission: NMDA Receptors and Hebb-Type Synaptic Plasticity

1988 • 484 citations

Temporally distinct pre- and post-synaptic mechanisms maintain long-term potentiation

1989 • 481 citations

Fodrin: axonally transported polypeptides associated with the internal periphery of many cells.

1981 • 480 citations

Associative long-term depression in the hippocampus induced by hebbian covariance

1989 • 470 citations

Reversal of the physiological effects of monocular deprivation in kittens: further evidence for a sensitive period

1974 • 449 citations

NMDA receptors in the visual cortex of young kittens are more effective than those of adult cats

1987 • 446 citations

Expression of 5-aminolaevulinate synthase and cytochrome P-450 mRNAs in chicken embryo hepatocytes in vivo and in culture. Effect of porphyrinogenic drugs and haem

1989 • 411 citations

Long-term potentiation of the perforant path in vivo is associated with increased glutamate release

1982 • 387 citations

Long-term potentiation as a candidate mnemonic device

1984 • 375 citations

Long-lasting facilitation of a synaptic potential following tetanization in thein vitro hippocampal slice

1975 • 340 citations

Protein kinase C injection into hippocampal pyramidal cells elicits features of long term potentiation

1987 • 340 citations

Development of neuronal selectivity in primary visual cortex of cat.

1984 • 336 citations

Activity-dependent disinhibition. I. Repetitive stimulation reduces IPSP driving force and conductance in the hippocampus in vitro

1989 • 328 citations

Long-Term Potentiation in the Motor Cortex

1989 • 320 citations

N‐methyl aspartate activates voltage‐dependent calcium conductance in rat hippocampal pyramidal cells.

1983 • 281 citations

Associative long-term potentiation in hippocampal slices.

1983 • 280 citations

Mechanisms of visual plasticity: Hebb synapses, NMDA receptors, and beyond

1991 • 274 citations

Profile of the sensitive period for monocular deprivation in kittens

1980 • 272 citations

A magnesium‐sensitive post‐synaptic potential in rat cerebral cortex resembles neuronal responses to N‐methylaspartate.

1986 • 249 citations

A new mechanism for glutamate receptor action: phosphoinositide hydrolysis

1988 • 241 citations

Excitatory amino acid synaptic mechanisms and neurological function

1986 • 231 citations

Frequency‐dependent N‐methyl‐D‐aspartate receptor‐mediated synaptic transmission in rat hippocampus.

1988 • 224 citations

Use‐dependent changes in synaptic efficacy in rat prefrontal neurons in vitro.

1990 • 221 citations

Messengers mediating Jong-term desensitization in cerebellar Purkinje cells

1990 • 219 citations

Ketamine—xylazine anaesthesia blocks consolidation of ocular dominance changes in kitten visual cortex

1987 • 206 citations

Characterization of protein F1 (47 kDa, 4.5 pI): A kinase C substrate directly related to neural plasticity

1985 • 204 citations

Identification of a spectrin-like protein in nonerythroid cells.

1981 • 198 citations

In search of cellular mechanisms of memory

1989 • 198 citations

Quantal analysis of excitatory synaptic action and depression in hippocampal slices

1991 • 197 citations

Asymmetric relationships between homosynaptic long-term potentiation and heterosynaptic long-term depression

1983 • 196 citations

Optimal Plasticity from Matrix Memories: What Goes Up Must Come Down

1990 • 195 citations

Long‐term potentiation and N‐methyl‐D‐aspartate receptors in the visual cortex of young rats.

1989 • 189 citations

Calcium/Calmodulin-Dependent Protein Kinase II

1990 • 182 citations

Long-term enhancement of evoked potentials in cat somatosensory cortex produced by co-activation of the basal forebrain and cutaneous receptors

1988 • 181 citations

PROPERTIES OF SYNAPTIC ACTIVITIES AND SPIKE POTENTIALS OF NEURONS IN IMMATURE NEOCORTEX

1965 • 177 citations

Maturation and Modification in the Developing Visual System

1978 • 174 citations

Brain mechanisms of perception and memory : from neuron to behavior

1993 • 171 citations

Immunoreactivity for a calmodulin-dependent protein kinase is selectively increased in macaque striate cortex after monocular deprivation.

1986 • 168 citations

Long-term potentiation in the hippocampus

1983 • 167 citations

Postsynaptic control of the induction of long-term changes in efficacy of transmission at neocortical synapses in slices of rat brain

1988 • 166 citations

Excitatory amino acid transmitters and their receptors in neural circuits of the cerebral neocortex

1990 • 166 citations

Learning-related synaptic plasticity: LTP and LTD

1991 • 165 citations

NMDA- and non-NMDA-receptor components of excitatory synaptic potentials recorded from cells in layer V of rat visual cortex

1988 • 164 citations

Glutamate receptor subtypes may be classified into two major categories: A study on Xenopus oocytes injected with rat brain mRNA

1989 • 163 citations

A Biochemical Correlate of the Critical Period for Synaptic Modification in the Visual Cortex

1989 • 163 citations

Developmental changes in the susceptibility to long-term potentiation of neurones in rat visual cortex slices

1991 • 158 citations

The Involvement of N‐Methyl‐D‐Aspartate Receptors in Induction and Maintenance of Long‐Term Potentiation in Rat Visual Cortex

1990 • 157 citations

Advances in neural and behavioral development

1985 • 155 citations

Statistical constraints on synaptic plasticity

1977 • 154 citations

Neuronal mechanisms of motor learning in mammals

1991 • 152 citations

Long-term potentiation of thalamic input to the motor cortex induced by coactivation of thalamocortical and corticocortical afferents

1991 • 150 citations

Long-lasting potentiation of synaptic potentials in the motor cortex produced by stimulation of the sensory cortex in the cat: a basis of motor learning

1987 • 148 citations

Long-term potentiation of synaptic transmission in kitten visual cortex

1988 • 147 citations

Long-lasting potentiation of synaptic transmission requires postnaptic modifications in the neocortex

1987 • 133 citations

Understanding the Cellular Basis of Memory and Learning

1986 • 133 citations

The Formation of Cooperative Cell Assemblies in the Visual Cortex

1991 • 130 citations

Long-term potentiations in vertebrate synapses: a variety of cascades with common subprocesses

1990 • 129 citations

Long-term changes in excitability of cortical neurons after Pavlovian conditioning and extinction.

1980 • 126 citations

Properties of associative long-lasting potentiation induced by cellular conditioning in the motor cortex of conscious cats

1991 • 123 citations

Effects of KN-62, a specific inhibitor of calcium/calmodulin-dependent protein kinase II, on long-term potentiation in the rat hippocampus

1991 • 123 citations

Mechanisms underlying potentiation of synaptic transmission in rat anterior cingulate cortex in vitro.

1991 • 122 citations

Excitatory Amino Acids and Neuronal Plasticity

1990 • 121 citations

Long-term potentiation investigated in a slice preparation of striate cortex of young kittens

1981 • 121 citations

The formation of cooperative cell assemblies in the visual cortex

1990 • 120 citations

Long-term potentiation in thin hippocampal sections studied by intracellular and extracellular recordings

1978 • 118 citations

The Visually Responsive Neuron: From Basic Neurophysiology to Behavior

1993 • 117 citations

Blockade of NMDA receptors unmasks a long-term depression in synaptic efficacy in rat prefrontal neurons in vitro

1991 • 117 citations

A critical period for long-term potentiation in the developing rat visual cortex

1988 • 117 citations

Inhibition of Excitatory Amino Acid‐Stimulated Phosphoinositide Hydrolysis in the Neonatal Rat Hippocampus by 2‐Amino‐3‐Phosphonopropionate

1989 • 114 citations

A Pertussis Toxin-Sensitive G Protein in Hippocampal Long-Term Potentiation

1989 • 114 citations

Synaptic facilitation requires paired activation of convergent pathways in the neocortex

1981 • 110 citations

Redistribution of fodrin (a component of the cortical cytoplasm) accompanying capping of cell surface molecules.

1983 • 109 citations

Induction but not maintenance of calcium-induced long-term potentiation in dentate gyrus and area CA1 of the hippocampal slice is blocked by nordihydroguaiaretic acid

1988 • 109 citations

The role of NMDA receptors in long-term potentiation (LTP) and depression (LTD) in rat visual cortex

1991 • 106 citations

Induction of long-term potentiation without participation of N-methyl-D-aspartate receptors in kitten visual cortex

1991 • 96 citations

2-Amino-3-phosphonopropionic acid, an inhibitor of glutamate-stimulated phosphoinositide turnover, blocks induction of homosynaptic long-term depression, but not potentiation, in rat hippocampus

1991 • 96 citations

Excitatory amino acid transmitters in neuronal circuits of the cat visual cortex

1986 • 96 citations

Identification and Location of Brain Protein 4.1

1984 • 95 citations

Roles of glutamate receptors in long-term potentiation at hippocampal mossy fiber synapses

1991 • 86 citations

Cross-depression: an electrophysiological manifestation of binocular competition in the developing visual cortex

1979 • 85 citations

Sustained enhancement of evoked potentials following brief, high-frequency stimulation of the cerebral cortex in vitro

1982 • 81 citations

Trifluoperazine inhibits hippocampal long-term potentiation and the phosphorylation of a 40,000 dalton protein

1980 • 81 citations

NMDA depolarizations and long-term potentiation are reduced in the aged rat neocortex

1990 • 81 citations

Actions of excitatory amino acid antagonists on synaptic potentials of layer II/III neurons of the cat's visual cortex

1989 • 78 citations

Postnatal changes in glutamate stimulated phosphoinositide turnover in rat neocortical synaptoneurosomes

1989 • 77 citations

Purification of a 240 000 M_r calmodulin‐binding protein from a microsomal fraction of brain

1981 • 77 citations

Horizontal long-term potentiation of responses in rat somatosensory cortex

1991 • 77 citations

Quantal analysis of potentiating action of phorbol ester on synaptic transmission in the hippocampus

1987 • 74 citations

Long-term depression at synapses in slices of rat hippocampus can be induced by bursts of postsynaptic activity

1990 • 63 citations

Identification of neurons producing long‐term potentiation in the cat motor cortex: Intracellular recordings and labeling

1990 • 62 citations

A comparison of the postnatal development of post-activation potentiation in the neocortex and dentate gyrus of the rat

1984 • 61 citations

Conditioned changes of synaptic transmission in the motor cortex of the cat

1978 • 61 citations

Non-Hebbian synapses in rat visual cortex

1990 • 60 citations

Long-term depression but not potentiation is induced in Ca2+-chelated visual cortex neurons

1990 • 60 citations

Induction of LTP in rat primary visual cortex: tetanus parameters

1989 • 59 citations

Blockade of tetanic- and calcium-induced long-term potentiation in the hippocampal slice preparation by neuroleptics

1984 • 57 citations

Laminar differences in development of afferent innervation to striate cortex neurones in kittens

1982 • 56 citations

Release of glutamate and aspartate from the visual cortex of the cat following activation of afferent pathways

1990 • 56 citations

Brain spectrin: A review

1984 • 54 citations

Long-term potentiation and depression in the cerebral neocortex.

1990 • 52 citations

Protein kinase C immunoreactivity in kitten visual cortex is developmentally regulated and input-dependent

1990 • 51 citations

Development of cortical inhibition in kitten striate cortex investigated by a slice preparation

1983 • 49 citations

Long-term potentiation in frontal cortex: Role of NMDA-modulated polysynaptic excitatory pathways

1989 • 48 citations

Pertussis toxin suppresses long-term potentiation of hippocampal mossy fiber synapses

1988 • 48 citations

Postnatal development of neuronal connections in cat visual cortex studied by intracellular recording in slice preparation

1991 • 47 citations

The postnatal development of post-activation potentiation in the rat neocortex

1983 • 44 citations

Amino acids as transmitters of synaptic excitation in neocortical sensory processes

1991 • 39 citations

Stimulation of Phosphoinositide Turnover by Excitatory Amino Acids

1991 • 34 citations

Long-term potentiation in the cat somatosensory cortex

1990 • 32 citations

Comparative aspects of hippocampal and neocortical long-term potentiation

1989 • 31 citations

Long-term facilitation of excitatory synaptic transmission in single motor cortical neurones of the cat produced by repetitive pairing of synaptic potentials and action potentials following intracellular stimulation

1981 • 31 citations

Intracellular studies on cortical synaptic plasticity

1981 • 30 citations

Memory, Learning and Higher Function: A Cellular View

1984 • 30 citations

Input-specific induction of long-term depression in Ca2+-chelated visual cortex neurons

1991 • 27 citations

Activation of protein kinase C induces long-term changes of postsynaptic currents in neocortical neurons

1988 • 26 citations

Must what goes up come down?

1989 • 25 citations

Intracellular injection of phorbol ester increases the excitability of neurons of the motor cortex of awake cats

1987 • 25 citations

Long-term depression is induced in Ca2+/calmodulin kinase-inhibited visual cortex neurons

1992 • 24 citations

Postnatal Development of Protein Kinase C-like Immunoreactivity in the Cat Visual Cortex

1989 • 22 citations

Long-term potentiation and depression in hippocampal slices

1986 • 21 citations

Failure to reverse long-term potentiation by coupling sustained presynaptic activity and N-methyl-D-aspartate receptor blockade.

1990 • 20 citations

Memory, learning and higher function. A cellular view

1983 • 19 citations

A Role of NMDA Receptors and Ca2+ Influx in Synaptic Plasticity in the Developing Visual Cortex

1990 • 13 citations

Development of phorbol ester (protein kinase C) binding sites in cat visual cortex

1988 • 12 citations

Postnatal development of immunohistochemically localized spectrin-like protein (calspectin or fodrin) in the rat visual cortex: Its excessive expression in developing cortical neurons

1987 • 12 citations

Immunohistochemical localization of a membrane‐associated, 4.1‐like protein in the rat visual cortex during postnatal development

1988 • 10 citations

Actions of excitatory amino acid antagonists on synaptic potentials of layer II／III neurons of cat visual cortex.

1989 • 2 citations