Amyloid-β Induces Chemokine Secretion and Monocyte Migration across a Human Blood-Brain Barrier Model

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

1993 • 3,693 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases

1995 • 1,290 citations

Paired Helical Filaments in Electron Microscopy of Alzheimer's Disease

1963 • 956 citations

beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease.

1993 • 713 citations

Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats

1996 • 500 citations

Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers.

1996 • 414 citations

Alzheimer’s Presenilin Mutation Sensitizes Neural Cells to Apoptosis Induced by Trophic Factor Withdrawal and Amyloid β-Peptide: Involvement of Calcium and Oxyradicals

1997 • 386 citations

Migration of Hematogenous Cells Through the Blood‐Brain Barrier and the Initiation of CNS Inflammation

1991 • 362 citations

Can disturbed brain microcirculation cause Alzheimer’s disease?

1993 • 340 citations

Mechanisms for the transendothelial migration of HIV-1-infected monocytes into brain.

1996 • 321 citations

A model for monocyte migration through the blood-brain barrier during HIV-1 encephalitis.

1997 • 316 citations

Amyloid β-Peptide Is Transported on Lipoproteins and Albumin in Human Plasma

1996 • 316 citations

Human immunodeficiency virus type 1 infection alters chemokine beta peptide expression in human monocytes: implications for recruitment of leukocytes into brain and lymph nodes.

1996 • 288 citations

Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain

1989 • 281 citations

Identification of monocyte chemoattractant protein‐1 in senile plaques and reactive microglia of Alzheimer's disease

1997 • 238 citations

Ultrastructural Studies of the Cells Forming Amyloid Fibers in Classical Plaques

1989 • 238 citations

Inflammation, Aβ Deposition, and Neurofibrillary Tangle Formation as Correlates of Alzheimer's Disease Neurodegeneration

1996 • 227 citations

MHC class II‐positive microglia in human brain: Association with alzheimer lesions

1992 • 221 citations

α ₂ -macroglobulin associates with β-amyloid peptide and prevents fibril formation

1998 • 216 citations

The role of complement and activated microglia in the pathogenesis of Alzheimer's disease

1996 • 205 citations

An integrative hypothesis concerning the pathogenesis and progression of Alzheimer's disease

1986 • 192 citations

OVERRIDING THE BRAIN'S INTRINSIC RESISTANCE TO LEUKOCYTE RECRUITMENT WITH INTRAPARENCHYMAL INJECTIONS OF RECOMBINANT CHEMOKINES

1996 • 181 citations

Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms

1997 • 180 citations

Role of microglia in senile plaque formation

1995 • 176 citations

TNF-α Opens a Paracellular Route for HIV-1 Invasion across the Blood-Brain Barrier

1997 • 163 citations

Brain Microvascular Changes in Alzheimer's Disease and Other Dementias^a

1997 • 159 citations

Microglial Activation in Alzheimer Disease: Association with APOE Genotype

1998 • 152 citations

EARLY AND LATE MECHANISMS OF INCREASED VASCULAR PERMEABILITY FOLLOWING EXPERIMENTAL CEREBRAL INFARCTION

1979 • 144 citations

Cell surface morphology identifies microglia as a distinct class of mononuclear phagocyte

1995 • 142 citations

Blood monocytes and spleen macrophages differentiate into microglia‐like cells on monolayers of astrocytes: Morphology

1994 • 141 citations

Cerebrovascular transport of Alzheimer's amyloidβ and apolipoproteins J and E: Possible anti-amyloidogenic role of the blood-brain barrier

1996 • 140 citations

Age-related changes in the blood-brain barrier

1997 • 119 citations

Modification of the Recalde method for the isolation of human monocytes.

1988 • 114 citations

Cerebrovascular Degeneration Is Related to Amyloid‐β Protein Deposition in Alzheimer's Disease^a

1997 • 105 citations

Experimental Listeria meningoencephalitis. Macrophage inflammatory protein-1 alpha and -2 are produced intrathecally and mediate chemotactic activity in cerebrospinal fluid of infected mice.

1995 • 99 citations

Hypoxia Dramatically Increases the Nonspecific Transport of Blood‐Borne Proteins to the Brain

1997 • 95 citations

Glycation and microglial reaction in lesions of Alzheimer's disease

1996 • 77 citations

Activated Microglial Cells Are Colocalized With Perivascular Deposits of Amyloid-β Protein in Alzheimer’s Disease Brain

1997 • 75 citations

Mononuclear cell trafficking and plasma protein extravasation into the CNS during chronic relapsing experimental allergic encephalomyelitis in Biozzi AB/H mice

1991 • 65 citations

Development of laboratory and animal model systems for HIV-1 encephalitis and its associated dementia

1997 • 56 citations

Regulation of HIV-1 infection in astrocytes: Expression of Nef, TNF-α and IL-6 is enhanced in coculture of astrocytes with macrophages

1996 • 49 citations

Observations of amyloid angiopathy and senile plaques by the scanning electron microscope

1979 • 44 citations

Molecular aspects of inflammatory and immune responses in Alzheimer's disease

1996 • 42 citations

Amyloid β protein and transthyretin, sequestrating protein colocalize in normal human kidney

1997 • 22 citations

Inflammatory Mediators in Alzheimer’s Disease

1997 • 21 citations

Inhibition of tumor necrosis factor-alpha (TNF-?) and interleukin-1 beta (IL-1?) secretion but not IL-6 from activated human peripheral blood monocytes by a new synthetic demethylpodophyllotoxin derivative

1994 • 20 citations

Regional quantitative permeability of blood-brain barrier lesions in rats with chronic renal hypertension

1992 • 7 citations

Transformation of bone marrow-derived macrophages into ramified microglia during autoimmune inflammation of the axotomized rat facial nucleus

1998 • 2 citations