Transcription therapy for cancer

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

1998 • 3,363 citations

A decade of molecular biology of retinoic acid receptors

1996 • 2,893 citations

Histone acetylation in chromatin structure and transcription

1997 • 2,834 citations

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1997 • 1,960 citations

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

1999 • 1,640 citations

Oncogenic Transcription Factors in the Human Acute Leukemias

1997 • 1,227 citations

Complete Remission after Treatment of Acute Promyelocytic Leukemia with Arsenic Trioxide

1998 • 1,220 citations

Histone Deacetylase Inhibitors: Inducers of Differentiation or Apoptosis of Transformed Cells

2000 • 1,158 citations

Role of the histone deacetylase complex in acute promyelocytic leukaemia

1998 • 1,091 citations

Histone deacetylase inhibitor selectively induces p21 ^WAF1 expression and gene-associated histone acetylation

2000 • 1,091 citations

Deconstructing a Disease: RAR, Its Fusion Partners, and Their Roles in the Pathogenesis of Acute Promyelocytic Leukemia

1999 • 1,042 citations

Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia

1998 • 1,021 citations

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases

1998 • 899 citations

Distinct interactions of PML-RARα and PLZF-RARα with co-repressors determine differential responses to RA in APL

1998 • 571 citations

ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex

1998 • 525 citations

Therapeutic Targeting of Transcription in Acute Promyelocytic Leukemia by Use of an Inhibitor of Histone Deacetylase

1998 • 517 citations

Retinoids in cancer therapy.

1992 • 505 citations

Aberrant Recruitment of the Nuclear Receptor Corepressor-Histone Deacetylase Complex by the Acute Myeloid Leukemia Fusion Partner ETO

1998 • 500 citations

Recognition of the four Watson–Crick base pairs in the DNA minor groove by synthetic ligands

1998 • 498 citations

Chemosensitisation of malignant melanoma by BCL2 antisense therapy

2000 • 487 citations

Regulation of gene expression by small molecules

1997 • 465 citations

Second generation hybrid polar compounds are potent inducers of transformed cell differentiation.

1996 • 421 citations

Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17)

1995 • 352 citations

Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein

1997 • 343 citations

Stat5 Is Essential for the Myelo- and Lymphoproliferative Disease Induced by TEL/JAK2

2000 • 310 citations

The Wilms Tumor Suppressor WT1 Encodes a Transcriptional Activator of amphiregulin

1999 • 308 citations

Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma

1994 • 302 citations

Oligomerization of RAR and AML1 Transcription Factors as a Novel Mechanism of Oncogenic Activation

2000 • 286 citations

Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma.

1995 • 285 citations

Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53

1999 • 282 citations

Sequence-specific DNA recognition by polyamides

1999 • 279 citations

The Signal Transducer and Activator of Transcription STAT5b Gene Is a New Partner of Retinoic Acid Receptor in Acute Promyelocytic-Like Leukaemia

1999 • 263 citations

Gli proteins and Hedgehog signaling: development and cancer

1999 • 249 citations

Acquisition of Oncogenic Potential by RAR Chimeras in Acute Promyelocytic Leukemia through Formation of Homodimers

2000 • 229 citations

Activation of the p21WAF1/CIP1 promoter independent of p53 by the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) through the Sp1 sites

2000 • 217 citations

Up-regulation of costimulatory/adhesion molecules by histone deacetylase inhibitors in acute myeloid leukemia cells

2000 • 196 citations

Retinoic acid (RA) and As ₂ O ₃ treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARα and PLZF-RARα oncoproteins

2000 • 193 citations

Activation of gene expression by small molecule transcription factors

2000 • 183 citations

Synthetic Zinc Finger Transcription Factor Action at an Endogenous Chromosomal Site

2000 • 174 citations

Two Critical Hits for Promyelocytic Leukemia

2000 • 147 citations

Fusion genes in solid tumors

1999 • 112 citations

In vivo analysis of the molecular pathogenesis of acute promyelocytic leukemia in the mouse and its therapeutic implications

1999 • 106 citations

Recognition of 16 Base Pairs in the Minor Groove of DNA by a Pyrrole−Imidazole Polyamide Dimer

1998 • 102 citations

Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARα fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)(q23;q21) APL patient

1999 • 100 citations

Chromatin Opening of DNA Satellites by Targeted Sequence-Specific Drugs

2000 • 77 citations

Histone deacetylase inhibitors and retinoic acids inhibit growth of human neuroblastoma in vitro

2000 • 57 citations

Depsipeptide (FR901228): A Novel Therapeutic Agent With Selective, In Vitro Activity Against Human B-Cell Chronic Lymphocytic Leukemia Cells

1999 • 43 citations

Antisense cancer therapy: The state of the science

2000 • 26 citations

Transcriptional regulation of cellular transformation

2000 • 22 citations

Oral isobutyramide reduces transfusion requirements in some patients with homozygous β-thalassemia

2000 • 3 citations