Epigenetic Regulation of Gelsolin Expression in Human Breast Cancer Cells

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Genomic sequencing.

1984 • 8,343 citations

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

1998 • 3,363 citations

CpG Islands in vertebrate genomes

1987 • 3,315 citations

Histone acetylation in chromatin structure and transcription

1997 • 2,834 citations

Caspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis

1998 • 1,927 citations

Histone acetylation and transcriptional regulatory mechanisms

1998 • 1,793 citations

Caspase-3-Generated Fragment of Gelsolin: Effector of Morphological Change in Apoptosis

1997 • 1,233 citations

Gene Expression Profiles in Normal and Cancer Cells

1997 • 1,157 citations

What's Up and Down with Histone Deacetylation and Transcription?

1997 • 831 citations

CpG methylation, chromatin structure and gene silencing---a three-way connection

1998 • 791 citations

Trichostatin A and trapoxin: Novel chemical probes for the role of histone acetylation in chromatin structure and function

1995 • 719 citations

The effect of sodium butyrate on histone modification

1978 • 680 citations

The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation.

1996 • 662 citations

INTERRELATIONSHIPS OF THE PATHWAYS OF mRNA DECAY AND TRANSLATION IN EUKARYOTIC CELLS

1996 • 653 citations

Acetylation of general transcription factors by histone acetyltransferases

1997 • 588 citations

How does DNA methylation repress transcription?

1997 • 532 citations

THE ROLE OF DNA METHYLATION IN CANCER GENETICS AND EPIGENETICS

1996 • 480 citations

Histone acetylation: chromatin in action

1997 • 475 citations

Suppression of histone deacetylation in vivo and in vitro by sodium butyrate.

1978 • 474 citations

Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin

1995 • 437 citations

Methylation of the BRCA1 gene in sporadic breast cancer.

1997 • 384 citations

Epigenetic silencing of RNA polymerase I transcription: a role for DNA methylation and histone modification in nucleolar dominance

1997 • 382 citations

Induction of caspase-3 protease activity and apoptosis by butyrate and trichostatin A (inhibitors of histone deacetylase): dependence on protein synthesis and synergy with a mitochondrial/cytochrome c-dependent pathway.

1997 • 376 citations

DNA methylation directs a time-dependent repression of transcription initiation

1997 • 372 citations

A role for histone deacetylase activity in HDAC1-mediated transcriptional repression

1998 • 363 citations

Mapping Patterns of CpG Island Methylation in Normal and Neoplastic Cells Implicates Both Upstream and Downstream Regions inde Novo Methylation

1997 • 323 citations

Enhanced Motility in NIH 3T3 Fibroblasts That Overexpress Gelsolin

1991 • 321 citations

Proteasome Inhibitors Activate Stress Kinases and Induce Hsp72

1998 • 304 citations

Transcriptional Regulation of the MDR1 Gene by Histone Acetyltransferase and Deacetylase Is Mediated by NF-Y

1998 • 289 citations

Gelsolin is a downstream effector of rac for fibroblast motility

1998 • 267 citations

Structure and Function of Actin

1992 • 264 citations

Actin dynamics in vivo

1997 • 239 citations

Internucleosomal DNA cleavage triggered by plasma membrane damage during necrotic cell death. Involvement of serine but not cysteine proteases.

1997 • 233 citations

Inactivation of p16 in Human Mammary Epithelial Cells by CpG Island Methylation

1998 • 231 citations

Gelsolin: Calcium‐ and polyphosphoinositide‐regulated actin‐ modulating protein

1987 • 228 citations

Alterations in DNA methylation may play a variety of roles in carcinogenesis

1995 • 220 citations

Trichostatin A causes selective loss of DNA methylation in Neurospora

1998 • 212 citations

Cell anchorage and the cytoskeleton as partners in growth factor dependent cell cycle progression

1997 • 203 citations

Trichostatin A Induces Morphological Changes and Gelsolin Expression by Inhibiting Histone Deacetylase in Human Carcinoma Cell Lines

1994 • 193 citations

Breast Cancer: Cellular and Molecular Biology

1988 • 182 citations

Genomic organization and biosynthesis of secreted and cytoplasmic forms of gelsolin

1988 • 165 citations

Apoptotic death in adenocarcinoma cell lines induced by butyrate and other histone deacetylase inhibitors

1997 • 160 citations

Bcl-xL Functions Downstream of Caspase-8 to Inhibit Fas- and Tumor Necrosis Factor Receptor 1-induced Apoptosis of MCF7 Breast Carcinoma Cells

1998 • 160 citations

A role for gelsolin in actuating epidermal growth factor receptor-mediated cell motility.

1996 • 155 citations

Quantitative Analysis of Apoptotic Cell Death Using Proton Nuclear Magnetic Resonance Spectroscopy

1997 • 153 citations

Mechanisms of inactivation of E-cadherin in breast cancer cell lines.

1998 • 148 citations

Chromosome 9 allelic losses and microsatellite alterations in human bladder tumors.

1994 • 147 citations

Inhibition of apoptosis by the actin-regulatory protein gelsolin

1997 • 141 citations

Induction of γ-Globin by Histone Deacetylase Inhibitors

1997 • 139 citations

Medical aspects of the actin cytoskeleton

1995 • 130 citations

Widespread loss of gelsolin in breast cancers of humans, mice, and rats.

1996 • 122 citations

Repression of the candidate tumor suppressor gene S100A2 in breast cancer is mediated by site-specific hypermethylation

1997 • 121 citations

Defects in the Ubiquitin Pathway Induce Caspase-independent Apoptosis Blocked by Bcl-2

1998 • 114 citations

INHIBITION OF IL-8 GENE EXPRESSION IN CACO-2 CELLS BY COMPOUNDS WHICH INDUCE HISTONE HYPERACETYLATION

1997 • 113 citations

Differential Display Cloning of a Novel Human Histone Deacetylase (HDAC3) cDNA from PHA-Activated Immune Cells

1998 • 110 citations

Stimulation of tissue-type plasminogen activator gene expression by sodium butyrate and trichostatin A in human endothelial cells involves histone acetylation

1995 • 109 citations

Cytotoxic effects of adenovirus-mediated wild-type p53 protein expression in normal and tumor mammary epithelial cells.

1995 • 107 citations

Bcl-2 expression regulates sodium butyrate-induced apoptosis in human MCF-7 breast cancer cells.

1996 • 101 citations

CpG methylation remodels chromatin structure in vitro

1997 • 101 citations

The Small GTP-binding Protein Rac Promotes the Dissociation of Gelsolin from Actin Filaments in Neutrophils

1998 • 94 citations

Gelsolin Modulates Phospholipase C Activity In Vivo through Phospholipid Binding

1997 • 90 citations

Phosphatidylinositol 4,5‐bisphosphate specifically stimulates PP60^c‐src catalyzed phosphorylation of gelsolin and related actin‐binding proteins

1997 • 86 citations

Dependence of Fibroblast Migration on Actin Severing Activity of Gelsolin

1996 • 85 citations

Profilin and Gelsolin Stimulate Phosphatidylinositol 3-Kinase Activity

1996 • 80 citations

A genomic element within the third intron of the human oxytocin receptor gene may be involved in transcriptional suppression

1997 • 79 citations

Human mammary epithelial cells in culture: differentiation and transformation

1988 • 77 citations

Specificity of seven monoclonal antibodies against p53 evaluated with Western blotting, immunohistochemistry, confocal laser scanning microscopy, and flow cytometry.

1997 • 74 citations

Gelsolin modulation in epithelial and stromal cells of mammary carcinoma.

1989 • 74 citations

Selective Inhibition of IL-Gene Expression by 2Trichostatin A, a Potent Inhibitor of Mammalian Histone Deacetylase.

1996 • 74 citations

Localization of gelsolin proximal to ABL on chromosome 9.

1988 • 69 citations

Phospholipase D Regulation by a Physical Interaction with the Actin-Binding Protein Gelsolin

1996 • 67 citations

Tumor-suppressive function of mutated gelsolin in ras-transformed cells.

1993 • 65 citations

Specificity of seven monoclonal antibodies against p53 evaluated with Western blotting, immunohistochemistry, confocal laser scanning microscopy, and flow cytometry

1997 • 58 citations

Actin and cell pathogenesis

1997 • 53 citations

Protease inhibitors block apoptosis at intermediate stages: a compared analysis of DNA fragmentation and apoptotic nuclear morphology

1995 • 51 citations

Growth factor dependency and gene expression in preneoplastic mouse mammary epithelial cells.

1993 • 44 citations

Conformational changes in actin induced by its interaction with gelsolin

1997 • 44 citations

Effect of sodium butyrate on human breast cancer cell lines

1997 • 43 citations

Demethylation of the progesterone receptor CpG island is not required for progesterone receptor gene expression

1998 • 39 citations

Apoptotic cell nuclei favour aggregation and fluorescence quenching of DNA dyes

1997 • 38 citations

Concurrent deregulation of gelsolin and cyclin D1 in the majority of human and rodent breast cancers

1999 • 31 citations

Apoptosis of Human Lymphocytes in the Absence or Presence of Internucleosomal DNA Cleavage

1996 • 29 citations

Actin, biophysics, biochemistry and cell biology

1995 • 28 citations

Spectrophotometric Quantitation of Tissue Culture Cell Number in Any Medium

1996 • 26 citations

Actin-Gelsolin Interaction

1994 • 21 citations

Methylation of CpG island is not a ubiquitous mechanism for the loss of oestrogen receptor in breast cancer cells

1998 • 19 citations

Actin: biophysics, biochemistry and cell biology

1995 • 15 citations

The application of NMR spectroscopy to the study of apoptosis.

1997 • 13 citations

Modulation of growth and differentiation of human colon carcinoma cells by histone deacetylase inhibitory trichostatins

1996 • 13 citations

Tissue- and species-specific regulation of murine alpha 1-antitrypsin gene transcription.

1988 • 10 citations