Novel AMPA receptor potentiators LY392098 and LY404187: effects on recombinant human AMPA receptors in vitro

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Cloned Glutamate Receptors

1994 • 3,989 citations

RNA editing in brain controls a determinant of ion flow in glutamate-gated channels

1991 • 1,465 citations

Ca2 ⁺ Permeability of KA-AMPA—Gated Glutamate Receptor Channels Depends on Subunit Composition

1991 • 1,458 citations

Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS

1990 • 1,234 citations

The Time Course of Glutamate in the Synaptic Cleft

1992 • 1,071 citations

Cloning by functional expression of a member of the glutamate receptor family

1989 • 1,009 citations

The Tetrameric Structure of a Glutamate Receptor Channel

1998 • 790 citations

Control of Kinetic Properties of AMPA Receptor Channels by Nuclear RNA Editing

1994 • 735 citations

Immunochemical characterization of the non-NMDA glutamate receptor using subunit-specific antibodies. Evidence for a hetero-oligomeric structure in rat brain.

1992 • 505 citations

Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteins

1994 • 424 citations

A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission

1997 • 413 citations

Hippocampal neurons exhibit cyclothiazide-sensitive rapidly desensitizing responses to kainate

1993 • 369 citations

Neuropharmacology of AMPA and kainate receptors

1998 • 362 citations

AMPA Receptor Flip/Flop Mutants Affecting Deactivation, Desensitization, and Modulation by Cyclothiazide, Aniracetam, and Thiocyanate

1996 • 343 citations

Kainate receptors are involved in synaptic plasticity

1999 • 328 citations

Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam.

1990 • 303 citations

Cyclothiazide differentially modulates desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor splice variants.

1994 • 295 citations

Activation and desensitization of glutamate-activated channels mediating fast excitatory synaptic currents in the visual cortex

1992 • 268 citations

Modulation of excitatory synaptic transmission by drugs that reduce desensitization at AMPA/kainate receptors

1991 • 252 citations

Modulation of the Time Course of Fast EPSCs and Glutamate Channel Kinetics by Aniracetam

1991 • 242 citations

Aniracetam reduces glutamate receptor desensitization and slows the decay of fast excitatory synaptic currents in the hippocampus.

1991 • 213 citations

Enhancement by an Ampakine of Memory Encoding in Humans

1997 • 205 citations

Activity of 2,3-benzodiazepines at Native Rat and Recombinant Human Glutamate Receptors In Vitro : Stereospecificity and Selectivity Profiles

1996 • 192 citations

Structural determinants of allosteric regulation in alternatively spliced AMPA receptors

1995 • 164 citations

A tetrameric subunit stoichiometry for a glutamate receptor–channel complex

1998 • 137 citations

Diazoxide blocks glutamate desensitization and prolongs excitatory postsynaptic currents in rat hippocampal neurons.

1992 • 123 citations

A centrally active drug that modulates AMPA receptor gated currents

1994 • 111 citations

Interactions among GYKI-52466, cyclothiazide, and aniracetam at recombinant AMPA and kainate receptors.

1995 • 105 citations

A Novel Allosteric Potentiator of AMPA Receptors: 4-[2-(Phenylsulfonylamino)ethylthio]-2,6-Difluoro-Phenoxyacetamide

1997 • 104 citations

Facilitation of glutamate receptors reverses an age-associated memory impairment in rats

1996 • 96 citations

Nootropic Drugs Positively Modulate α‐Amino‐3‐Hydroxy‐5‐Methyl‐4‐Isoxazolepropionic Acid‐Sensitive Glutamate Receptors in Neuronal Cultures

1992 • 94 citations

Pentameric subunit stoichiometry of a neuronal glutamate receptor.

1996 • 94 citations

7-Chloro-3-methyl-3-4-dihydro-2H-1,2,4 benzothiadiazine S,S-dioxide (IDRA 21): a benzothiadiazine derivative that enhances cognition by attenuating DL-alpha-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid (AMPA) receptor desensitization.

1995 • 90 citations

Aniracetam has proportionately smaller effects on synapses expressing long-term potentiation: Evidence that receptor changes subserve LTP

1990 • 50 citations

7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21), a congener of aniracetam, potently abates pharmacologically induced cognitive impairments in patas monkeys.

1995 • 49 citations

Pharmacological characterization of a GluR6 kainate receptor in cultured hippocampal neurons

1999 • 42 citations

Enantioselective synthesis of a pyrrolo-benzothiadiazine derivative S 18986, a new AMPA receptor positive modulator

1996 • 41 citations

Pharmacological effects of AMPA receptor potentiators LY392098 and LY404187 on rat neuronal AMPA receptors in vitro

2001 • 36 citations

Functional expression and pharmacological characterization of the human EAA4 (GluR6) glutamate receptor: a kainate selective channel subunit.

1994 • 33 citations

cDNA cloning and functional properties of human glutamate receptor EAA3 (GluR5) in homomeric and heteromeric configuration.

1995 • 30 citations

The contributions of GluR2 to allosteric modulation of AMPA receptors

2000 • 25 citations

Cloning, expression and pharmacological characterization of a human glutamate receptor: hGluR4.

1995 • 25 citations

A desensitization-inhibiting mutation in the glutamate binding site of rat α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits is dominant in heteromultimeric complexes

1999 • 9 citations