A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan

A C. elegans mutant that lives twice as long as wild type

1993 • 3,250 citations

Effects of Human Growth Hormone in Men over 60 Years Old

1990 • 1,560 citations

Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

2001 • 1,398 citations

Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1

1990 • 1,211 citations

Evolution of senescence: late survival sacrificed for reproduction

1991 • 1,066 citations

Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

2001 • 1,013 citations

The Retardation of Aging in Mice by Dietary Restriction: Longevity, Cancer, Immunity and Lifetime Energy Intake

1986 • 968 citations

Regulation of Longevity and Stress Resistance by Sch9 in Yeast

2001 • 858 citations

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

2001 • 814 citations

Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism

1996 • 787 citations

Metallothionein-Human GH Fusion Genes Stimulate Growth of Mice

1983 • 699 citations

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

1998 • 680 citations

The Insulin-Like Growth Factors

1993 • 647 citations

Impaired growth hormone secretion in the adult population: relation to age and adiposity.

1981 • 643 citations

Age-Related Change in the Twenty-Four Hour Spontaneous Secretion of Growth Hormone

1972 • 640 citations

A Conserved Regulatory System for Aging

2001 • 526 citations

Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway

2001 • 494 citations

Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice.

1997 • 432 citations

Extending the lifespan of long-lived mice

2001 • 425 citations

A prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women.

2000 • 407 citations

Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation.

1990 • 404 citations

Increased Life-Span of age -1 Mutants in Caenorhabditis elegans and Lower Gompertz Rate of Aging

1990 • 402 citations

Cell Nonautonomy of C. elegans daf-2 Function in the Regulation of Diapause and Life Span

1998 • 362 citations

A test of evolutionary theories of senescence

1980 • 349 citations

DWARF, A NEW MENDELIAN RECESSIVE CHARACTER OF THE HOUSE MOUSE

1929 • 324 citations

Molecular mechanisms linking calorie restriction and longevity

2002 • 303 citations

The Role of the Insulin-like Growth Factor System in Human Cancer

1996 • 295 citations

Decreased Pulsatile Release of Growth Hormone in Old Male Rats*

1980 • 272 citations

Insulin-like growth factor-1 ameliorates age-related behavioral deficits

1998 • 271 citations

Inherited Ateliotic Dwarfism in Mice: Characteristics of the mutation, little, on Chromosome 6

1976 • 241 citations

Growth inhibition of human breast cancer cells in vitro with an antibody against the type I somatomedin receptor.

1989 • 233 citations

Pleiotropic Effects of Growth Hormone and Insulin-like Growth Factor (IGF)-1 on Biological Aging: Inferences From Moderate Caloric-Restricted Animals

1999 • 220 citations

Autonomous growth of a human neuroblastoma cell line is mediated by insulin-like growth factor II.

1989 • 188 citations

Reduced Levels of Thyroid Hormones, Insulin, and Glucose, and Lower Body Core Temperature in the Growth Hormone Receptor/Binding Protein Knockout Mouse

2001 • 167 citations

Absence of Sleep-Related Growth Hormone Peaks in Aged Normal Subjects and in Acromegaly

1972 • 163 citations

Blockade of the insulin‐like growth‐factor‐I receptor inhibits growth of human colorectal cancer cells: Evidence of a functional IGF‐II‐mediated autocrine loop

1994 • 143 citations

Prolonged longevity of hypopituitary dwarf mice

2001 • 133 citations

Kleemeier Award Lecture: Are There Genes for Aging?

1999 • 127 citations

Human osteosarcoma cell lines are dependent on insulin-like growth factor I for in vitro growth.

1994 • 125 citations

Does growth hormone prevent or accelerate aging?

1998 • 121 citations

Premature ageing in transgenic mice expressing different growth hormone genes.

1993 • 121 citations

Type 1 IGF receptor in human breast diseases

1992 • 120 citations

Growth-promoting effects of insulin-like growth factor-1 (IGF-1) on hematopoietic cells: overexpression of introduced IGF-1 receptor abrogates interleukin-3 dependency of murine factor-dependent cells by a ligand-dependent mechanism

1991 • 112 citations

Effects of growth hormone on hypothalamic catalase and Cu/Zn superoxide dismutase1

2000 • 109 citations

A Personal History of the Origin of the Somatomedin Hypothesis and Recent Challenges to Its Validity

1989 • 103 citations

Regulation of breast cancer growth by insulin-like growth factors

1990 • 100 citations

Expression of prolactin and growth hormone receptor genes and their isoforms in the gastrointestinal tract

1995 • 90 citations

Antibody to type I insulinlike growth factor receptor inhibits growth of Wilms' tumor in culture and in athymic mice.

1989 • 88 citations

Low somatomedin-C levels in older men rise in response to growth hormone administration.

1981 • 84 citations

Studies of aging in ames dwarf mice: Effects of caloric restriction

2000 • 82 citations

Chronic [D-Ala2]-growth hormone-releasing hormone administrationattenuates age-related deficits in spatial memory

2000 • 79 citations

The synthetic retinoid fenretinide lowers plasma insulin-like growth factor I levels in breast cancer patients.

1993 • 79 citations

Enzymatic conversion of IGF-I to des(1–3)IGF-I in rat serum and tissues: a further potential site of growth hormone regulation of IGF-I action

1995 • 78 citations

Human osteosarcoma (U‐2 OS) cells express both insulin‐like growth factor‐I (IGF‐I) receptors and insulin‐like growth factor‐II/mannose‐6‐phosphate (IGF‐II/M6P) receptors and synthesize IGF‐II: Autocrine growth stimulation by IGF‐II via the IGF‐I receptor

1994 • 70 citations

Effect of rat age on serum levels of growth hormone and somatomedins

1981 • 69 citations

Insulin-Like Growth Factor-1 Selectively Increases Glucose Utilization in Brains of Aged Animals

2001 • 66 citations

Growth hormone induces somatostatin and insulin-like growth factor I gene expression in the cerebral hemispheres of aging rats.

1996 • 65 citations

Expression of insulin-like growth factor receptors I and II in normal human lung and in lung cancer

1993 • 62 citations

Processing of insulin-like growth factor-II (IGF-II) by human breast cancer cells

1994 • 60 citations

Growth Hormone Increases Regional Coronary Blood Flow and Capillary Density in Aged Rats

2001 • 55 citations

Preliminary results on plasma progesterone levels during pregnancy and superfetation in the hare, Lepus europaeus

1976 • 53 citations

Insulin-like growth factor-I and human lung fibroblast-derived insulin-like growth factor-I stimulate the proliferation of human lung carcinoma cells in vitro.

1993 • 46 citations

Characterization of insulin-like growth factor I receptors and growth effects in human lung cancer cell lines

1992 • 46 citations

Effects of insulin-like growth factor receptor inhibition on human melanomas in culture and in athymic mice.

1993 • 39 citations

Insulin-Like Growth Factor-1 Selectively Increases Glucose Utilization in Brains of Aged Animals

2001 • 36 citations

IGF-I and IGF-II expression in human breast cancer xenografts: Relationship to hormone independence

1992 • 29 citations

Partial characterization of insulin-like growth factor I in primary human lung cancers using immunohistochemical and receptor autoradiographic techniques.

1990 • 23 citations

Growth hormone treatment increases transmural colonic growth in GH-deficient dwarf rats

2000 • 17 citations

Regulation of Postjatal Intestinal Maturation by Growth Hormone: Studies in Rats with Isolated Growth Hormone Deficiency

1996 • 10 citations

Pituitary-Induced Alterations in Gastrin Levels and Gastrointestinal Growth in Normal and Genetically Dwarf Mice

1979 • 6 citations