Pleiotropic Effects of Growth Hormone and Insulin-like Growth Factor (IGF)-1 on Biological Aging: Inferences From Moderate Caloric-Restricted Animals

Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone

1973 • 3,509 citations

Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour

1982 • 1,092 citations

Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

1993 • 988 citations

The Retardation of Aging in Mice by Dietary Restriction: Longevity, Cancer, Immunity and Lifetime Energy Intake

1986 • 968 citations

Somatomedin-C Mediates Growth Hormone Negative Feedback by Effects on Both the Hypothalamus and the Pituitary

1981 • 829 citations

Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.

1994 • 792 citations

Dietary Restriction in Mice Beginning at 1 Year of Age: Effect on Life-Span and Spontaneous Cancer Incidence

1982 • 757 citations

Evidence for an Endogenous Ultradian Rhythm Governing Growth Hormone Secretion in the Rat

1976 • 743 citations

Impaired growth hormone secretion in the adult population: relation to age and adiposity.

1981 • 643 citations

Age-Related Change in the Twenty-Four Hour Spontaneous Secretion of Growth Hormone

1972 • 640 citations

Life Span Study of SPF Fischer 344 Male Rats Fed AdLibitum or Restricted Diets: Longevity, Growth, Lean Body Mass and Disease

1982 • 573 citations

Identification of the Iron-Responsive Element for the Translational Regulation of Human Ferritin mRNA

1987 • 547 citations

Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates.

1993 • 543 citations

Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain.

1996 • 493 citations

Tissue Distribution of Insulin-Like Growth Factor I and II Messenger Ribonucleic Acid in the Adult Rat*

1987 • 418 citations

Effects of Short Term Administration of Recombinant Human Growth Hormone to Elderly People*

1990 • 375 citations

Iron regulates ferritin mRNA translation through a segment of its 5' untranslated region.

1987 • 365 citations

Human cerebral blood flow and oxygen consumption as related to aging

1956 • 332 citations

Cerebral blood flow changes in benign aging and cerebrovascular disease

1984 • 316 citations

Effect of Age and Caloric Intake on Protein Oxidation in Different Brain Regions and on Behavioral Functions of the Mouse

1996 • 290 citations

Isolation, primary structure, and synthesis of human hypothalamic somatocrinin: growth hormone-releasing factor.

1984 • 288 citations

GH3 pituitary adenoma cells can reverse thymic aging in rats.

1986 • 282 citations

Insulin-like growth factor I (IGF-I) stimulates regeneration of the rat sciatic nerve

1989 • 280 citations

Reduction in regional cerebral blood flow during normal aging in man.

1980 • 280 citations

Decreased Pulsatile Release of Growth Hormone in Old Male Rats*

1980 • 272 citations

A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron.

1987 • 250 citations

Differential Effects of Estrogen and Growth Hormone on Uterine and Hepatic Insulin-Like Growth Factor I Gene Expression in the Ovariectomized Hypophysectomized Rat*

1988 • 236 citations

Growth inhibition of human breast cancer cells in vitro with an antibody against the type I somatomedin receptor.

1989 • 233 citations

AGE-RELATED CHANGES IN PLASMA GROWTH HORMONE RESPONSE TO GROWTH HORMONE-RELEASING FACTOR IN MAN

1984 • 232 citations

Insulin-like growth factor I (IGF I) stimulates DNA synthesis in fetal rat brain cell cultures

1983 • 230 citations

Effects of Growth Hormone-Releasing Hormone and Somatostatin on Sleep EEG and Nocturnal Hormone Secretion in Male Controls

1992 • 211 citations

Growth hormone rapidly activates insulin-like growth factor I gene transcription in vivo.

1992 • 211 citations

Somatomedin-C Levels in Healthy Young and Old Men: Relationship to Peak and 24-Hour Integrated Levels of Growth Hormone

1985 • 205 citations

Endurance training amplifies the pulsatile release of growth hormone: effects of training intensity

1992 • 199 citations

Growth and behavioral changes in developing rats treated intracisternally with 6-hydroxydopamine: evidence for involvement of brain dopamine.

1973 • 198 citations

Insulin-like growth factor I receptors in neuronal and glial cells. Characterization and biological effects in primary culture.

1987 • 190 citations

Translational control of insulin biosynthesis. Evidence for regulation of elongation, initiation and signal-recognition-particle-mediated translational arrest by glucose

1986 • 187 citations

Inhibition of cellular proliferation by peptide analogues of insulin-like growth factor 1.

1992 • 183 citations

New Insights Into the Mammalian Circadian Clock

1996 • 176 citations

Insulin and insulin-like growth factor II permit nerve growth factor binding and the neurite formation response in cultured human neuroblastoma cells.

1984 • 168 citations

The significance of sleep onset and slow wave sleep for nocturnal release of growth hormone (GH) and cortisol

1988 • 166 citations

Stimulation by growth hormone of MAP kinase activity in 3T3-F442A fibroblasts.

1992 • 164 citations

Both subunits of rat liver ferritin are regulated at a translational level by iron induction

1986 • 164 citations

Effects of Growth Hormone Excess and Deficiency on Hypothalamic Somatostatin Content and Release and on Tissue Somatostatin Distribution*

1981 • 164 citations

Absence of Sleep-Related Growth Hormone Peaks in Aged Normal Subjects and in Acromegaly

1972 • 163 citations

Growth Hormone (GH) Responsiveness to Combined Administration of Arginine and GH-Releasing Hormone Does not Vary with Age in Man*

1990 • 162 citations

Estrogen and insulin synergism in neurite growth enhancement in vitro: mediation of steroid effects by interactions with growth factors?

1988 • 148 citations

The Effect of Recombinant Human Growth Hormone on Malnourished Older Individuals

1991 • 146 citations

The iron-responsive element binding protein: a method for the affinity purification of a regulatory RNA-binding protein.

1989 • 144 citations

Relationship of insulin-like growth factor II gene expression in muscle to synaptogenesis.

1989 • 143 citations

Feedback Regulation of Growth Hormone (GH)-Releasing Hormone Gene Expression by GH in Rat Hypothalamus

1988 • 142 citations

Purification of a Specific Repressor of Ferritin mRNA Translation from Rabbit Liver

1989 • 138 citations

Influence of the Restriction of Individual Dietary Components on Longevity And Age-Related Disease of Fischer Rats: The Fat Component and the Mineral Component

1988 • 132 citations

Reduction in rate of occurrence of age related lesions in dietary restricted laboratory mice.

1991 • 123 citations

Premature ageing in transgenic mice expressing different growth hormone genes.

1993 • 121 citations

Insulin-like growth factors and neonatal cardiomyocyte development: ventricular gene expression and membrane receptor variations in normotensive and hypertensive rats

1989 • 121 citations

Regenerating endothelial cells express insulin-like growth factor-I immunoreactivity after arterial injury

1987 • 119 citations

Regulation of insulin-like growth factor I messenger RNA levels in vascular smooth muscle cells.

1991 • 113 citations

Handbook of physiology, section 11: Aging

1996 • 111 citations

Insulin-like growth factors cross the blood-brain barrier

1994 • 107 citations

The Insulin-Like Growth Factor I Generation Test: Resistance to Growth Hormone With Aging and Estrogen Replacement Therapy

1994 • 106 citations

Indispensable Role of Tissue-Type Plasminogen Activator in Growth Factor-Dependent Tube Formation of Human Microvascular Endothelial Cells in Vitro

1993 • 104 citations

A Personal History of the Origin of the Somatomedin Hypothesis and Recent Challenges to Its Validity

1989 • 103 citations

Stabilization of tubulin mRNAs by insulin and insulin-like growth factor I during neurite formation

1989 • 103 citations

Regulation of breast cancer growth by insulin-like growth factors

1990 • 100 citations

Reduced growth hormone releasing factor (GHRF)-like immunoreactivity and GHRF gene expression in the hypothalamus of aged rats

1989 • 96 citations

Overexpression of the Human Insulinlike Growth Factor I Receptor Promotes Ligand-Dependent Neoplastic Transformation

1990 • 92 citations

Infertility in transgenic female mice with human growth hormone expression: Evidence for luteal failure

1988 • 90 citations

Antibody to type I insulinlike growth factor receptor inhibits growth of Wilms' tumor in culture and in athymic mice.

1989 • 88 citations

Growth Hormone Restores Protein Synthesis in Skeletal Muscle of Old Male Rats

1985 • 88 citations

Nerve growth factor synthesis in vascular smooth muscle.

1991 • 87 citations

Diminished Pituitary Responsiveness to Growth Hormone-Releasing Factor in Aging Male Rats*

1986 • 84 citations

Low somatomedin-C levels in older men rise in response to growth hormone administration.

1981 • 84 citations

Effects of CNS Active Drugs and Somatostatin Antiserum on Growth Hormone Release in Young and Old Male Rats

1981 • 84 citations

Neuritic plaques and vessels of visual cortex in aging and Alzheimer's dementia

1990 • 81 citations

Effects of long-term, low-dose growth hormone therapy on immune function and life expectancy of mice

1991 • 81 citations

Insulin-like growth factor I gene expression in vascular cells.

1991 • 79 citations

The synthetic retinoid fenretinide lowers plasma insulin-like growth factor I levels in breast cancer patients.

1993 • 79 citations

Decreases in Cerebral Microvasculature with Age Are Associated with the Decline in Growth Hormone and Insulin-Like Growth Factor 1

1997 • 74 citations

Decrease in cellular replicative potential in “giant” mice transfected with the bovine growth hormone gene correlates to shortened life span

1993 • 73 citations

Oxidative DNA damage levels in rats fed low-fat, high-fat, or calorie-restricted diets

1992 • 71 citations

Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action.

1984 • 71 citations

Rat astroglial somatomedin/insulin-like growth factor binding proteins: characterization and evidence of biologic function

1988 • 70 citations

Effect of rat age on serum levels of growth hormone and somatomedins

1981 • 69 citations

Moderate Caloric Restriction Alters the Subcellular Distribution of Somatostatin mRNA and Increases Growth Hormone Pulse Amplitude in Aged Animals

1995 • 67 citations

Insulin/insulin‐like growth factor I and other epigenetic modulators of myelin basic protein expression in isolated oligodendrocyte progenitor cells

1988 • 64 citations

Transient expression of insulin-like growth factor I immunoreactivity by vascular cells during angiogenesis

1989 • 63 citations

Expression of insulin-like growth factor receptors I and II in normal human lung and in lung cancer

1993 • 62 citations

Activation of Cholinergic Neurotransmission by Pyridostigmine Reverses the Inhibitory Effect of Hyperglycemia on Growth Hormone (GH) Releasing Hormone-Induced GH Secretion in Man: Does Acute Hyperglycemia Act through Hypothalamic Release of Somatostatin?

1989 • 62 citations

Stable Xenon CT Cerebral Blood Flow Measurements Computed by a Single Compartment-Double Integration Model in Normal Aging and Dementia

1982 • 61 citations

Correlation of behavioral and cerebrovascular functions in the aging rat

1987 • 60 citations

Caloric Restriction: Conservation of Cellular Replicative Capacity in Vitro Accompanies Life-Span Extension in Mice

1995 • 58 citations

Effect of Dietary Restriction on Liver Protein Synthesis in Rats

1985 • 58 citations

Increased secretion of somatostatin-28 from hypothalamic neurons of aged rats in vitro

1986 • 57 citations

Effects of moderate caloric restriction on cortical microvascular density and local cerebral blood flow in aged rats☆

1999 • 55 citations

Moderate caloric restriction increases type 1 IGF receptors and protein synthesis in aging rats

1993 • 54 citations

Effect of Age and IGF-I Administration on Elastin Gene Expression in Rat Aorta

1990 • 52 citations

In vivo growth hormone treatment rapidly stimulates the tyrosine phosphorylation and activation of Stat3

1995 • 47 citations

Presence of a Somatomedin-C-Immunoreactive Substance in the Central Nervous System: Immunohistochemical Mapping Studies

1987 • 47 citations

Somatostatin gene expression in hypothalamus and cortex of aging male rats

1990 • 47 citations

Insulin-like growth factor-I and human lung fibroblast-derived insulin-like growth factor-I stimulate the proliferation of human lung carcinoma cells in vitro.

1993 • 46 citations

Increased Pituitary Response to Somatostatin in Aging Male Rats: Relationship to Somatostatin Receptor Number and Affinity

1989 • 46 citations

Characterization of insulin-like growth factor I receptors and growth effects in human lung cancer cell lines

1992 • 46 citations

Effects of Heterologous Growth Hormones on Hypothalamic and Pituitary Function in Transgenic Mice

1991 • 46 citations

Effect of age and dietary restriction on protein synthesis by isolated kidney cells

1985 • 44 citations

Insulin-like growth factor-1 stimulation of protein synthesis is attenuated in cerebral cortex of aging rats

1995 • 40 citations

Effect of Hypophysectomy on Hypothalamic Growth Hormone-Releasing Factor Content and Release in the Rat*

1987 • 40 citations

Effects of insulin-like growth factor receptor inhibition on human melanomas in culture and in athymic mice.

1993 • 39 citations

Age-Related Alterations in the Arterial Microvasculature of Skeletal Muscle

1992 • 38 citations

Growth Hormone Releasing Hormone Induced Release of Growth Hormone in Aging Male Rats: Dependence on Pharmacological Manipulation and Endogenous Somatostatin Release

1988 • 37 citations

Aged-Rodent Models of Long-Term Growth Hormone Therapy: Lack of Deleterious Effect on Longevity

1998 • 33 citations

GH Binding to Liver in Young and Old Female Rats: Relation to Somatomedin-C Secretion

1987 • 32 citations

Feedback effects of growth hormone on growth hormone-releasing hormone and somatostatin are not evident in aged rats

1993 • 32 citations

Growth hormone-induced nuclear translocation of Stat-3 decreases with age: modulation by caloric restriction

1996 • 25 citations

Growth hormone induces somatostatin and insulin-like growth factor I gene expression in the cerebral hemispheres of aging rats

1996 • 24 citations

Growth promoting effects of IGF‐I on fetal hypothalamic cell lines under serum‐free culture conditions

1989 • 24 citations

Postreceptor signaling mechanisms for growth hormone

1994 • 23 citations

Moderate Caloric Restriction Prevents the Age-Related Decline in Growth Hormone Receptor Signal Transduction

1996 • 23 citations

Partial characterization of insulin-like growth factor I in primary human lung cancers using immunohistochemical and receptor autoradiographic techniques.

1990 • 23 citations

Decreases in growth hormone receptor signal transduction contribute to the decline in insulin-like growth factor I gene expression with age

1995 • 21 citations

Plasma Growth Hormone in Men and Women over 70 Years of Age

2015 • 17 citations

The importance of hypophyseal hormones for structural cardiovascular adaptation in hypertension

1988 • 16 citations

Inhibition of the mitogenic effects of plasma by a monoclonal antibody to somatomedin C.

1984 • 14 citations

Effects of human growth hormone on reproductive and neuroendocrine functions in transgenic mice.

1991 • 10 citations

Effects of Caloric Restriction on the Maintenance of Genetic Fidelity

1990 • 6 citations

An Overview of the Biological Actions and Neuroendocrine Regulation of Growth Hormone

2020 • 2 citations

Chronic [DAla2] GHRH Administration Increases Working Memory in Aged Animals

1997 • 1 citations